A5034991241- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Surface Roughness and Optical Measurements
- Adhesion, Friction, and Surface Interactions
- Complement system in diseases
- Tribology and Lubrication Engineering
- Immune Response and Inflammation
- Eosinophilic Disorders and Syndromes
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Blood groups and transfusion
- Atmospheric and Environmental Gas Dynamics
- Immune cells in cancer
- Hemoglobinopathies and Related Disorders
- Remote Sensing in Agriculture
- Lymphoma Diagnosis and Treatment
- Advanced Numerical Analysis Techniques
- Organ Donation and Transplantation
- Magnesium in Health and Disease
- Fire effects on ecosystems
- Calibration and Measurement Techniques
- Organ Transplantation Techniques and Outcomes
- Morinda citrifolia extract uses
University of Dar es Salaam
2021
Tanzania Commission for Science and Technology
2021
National Centre for Earth Observation
2018-2019
University College London
2015-2019
University of Leicester
2019
ExxonMobil (United States)
2017
Natural Environment Research Council
2015
University of Huddersfield
2004-2006
University of Rochester Medical Center
1983-2004
University of Rochester
1982-2002
The RAdiative transfer Model Intercomparison (RAMI) activity focuses on the benchmarking of canopy radiative (RT) models. For current fourth phase RAMI, six highly realistic virtual plant environments were constructed basis intensive field data collected from (both deciduous and coniferous) forest stands as well test sites in Europe South Africa. Twelve RT modelling groups provided simulations scale (directional hemispherically integrated) quantities, a series binary hemispherical...
Background. Alloantibody-mediated acute rejection is a major cause of renal allograft loss despite aggressive therapy. Patients with humoral can be identified high sensitivity and specificity by the presence peritubular capillary C4d staining on biopsy donor-specific anti-human leukocyte antigen antibodies. Standard therapy for (AHR) has been removal antibodies plasmapheresis (PPH) in conjunction intravenous immunoglobulin We describe series seven patients positive AHR who received combined...
Three classes of FcR have been defined on human myeloid cells by their reactivity with mAb; FcRI (mAb 32); FcRII IV3); and FcRIII 3G8). We quantitated the expression each leukemia cell lines (KG-1, HL-60, U937, K562). Detailed analysis surface is provided for U937 line after exposure to CSF cytokines. Increased occurred at 72 h in exposed GCT or Mo line-conditioned medium as well from PHA-treated mononuclear cells. The augmentation required protein synthesis was diminished a neutralizing...
The Leukemia Intergroup Study has treated 110 patients with acute nonlymphocytic leukaemia 'high dose' cytosine arabinoside remission induction therapy and studied the factors which were related to outcome of therapy. With respect death during therapy, only patient age was prognostic significance. Treatment failure due resistant associated a high pretherapy leukaemic cell mass, presence few cells in S phase, insensitivity DNA synthesis arabinoside. If, after 6 d more than 40% marrow...
Two hundred patients with acute nonlymphocytic leukaemia received remission induction therapy consisting of cytosine arabinoside and an anthracycline antibiotic. Analysis the pretherapy characteristics demonstrated that patient age was most important factor in determining whether or not would survive therapy. Assessment bone marrow after 6 d permitted recognition who were likely to fail enter because persistent leukaemia. Taken together, these observations demonstrate it is possible identify...
S ummary . The relationship between the pretherapy cell cycle characteristics of leukaemic marrow cells and outcome remission‐induction therapy for acute nonlymphocytic leukaemia was studied in newly diagnosed relapsed patients who were then treated with either combination chemotherapy consisting cytosine arabinoside/anthracycline antibiotic 6 thioguanine or single agent high‐dose arabinoside therapy. highly dependent upon per cent phase no remissions occurring whom 3 H‐TdR labelling index...
Abstract The extracellular ionized calcium and magnesium requirements for lectin‐induced lymphocyte DNA synthesis were measured in a serum‐free system. use of this system permitted measurements the concentrations with ion‐selective electrodes. Maximal was observed at 270 μ 100 phytohemagglutinin‐treated lymphocytes. Lymphocyte much more sensitive to reduction external than magnesium. In calcium‐free medium (ionized 25 μM), reduced by 90%, but magnesium‐free concentration 7 μM) only 30%....
Abstract Seven institutions studied the cloning pattern of leukemic cells from pretherapy bone marrows 273 patients with newly presenting and relapsed acute nonlymphoblastic leukemia. The assay was done in all centers using an identical double‐layer agar method a common source colony‐stimulating factor. Cells were incubated for seven days, clones identified visually inverted microscope. All able to obtain clonal growth substantial proportion patients. Differences observed between major...
Abstract. Quantitative information on the error properties of global satellite-derived burned area (BA) products is essential for evaluating quality these products, e.g. against modelled BA estimates. We estimate theoretical uncertainties three widely used using a multiplicative triple collocation model. The approach provides spatially unique at 1∘ Moderate Resolution Imaging Spectroradiometer (MODIS) Collection 6 product (MCD64), MODIS 5.1 (MCD45) product, and European Space Agency (ESA)...
Abstract Eighteen patients with acute nonlymphocytic leukemia (ANLL), aged 17–73 years, were treated high‐dose cytosine arabinoside (HD‐Ara‐C)) using 3 g/m 2 IV q 12 hours × doses. Seven for relapse and four (57%) obtained a complete remission median duration of 19.5 weeks. In nine patients, refractory to conventional chemotherapy, no responders observed. Treatment failure was most commonly due drug resistance. Two elderly ANLL not previously exposed chemotherapy died during the initial...
Abstract We have shown that the murine lymphoblast, L5178Y, requires extracellular magnesium or calcium for proliferation in suspension culture. Although both cations produce biphasic effects on growth, is more potent since it: (1) stimulates at lower concentrations; (2) supports optimal over a wider concentration range; (3) maintains higher cell densities stationary phase; and (4) produces less inhibition high concentration. At suboptimal concentrations, facilitates effect of but...
Abstract Lymphomas are an uncommon complication of solid organ transplantation and rarely occur after marrow transplantation. When post‐marrow transplant lymphomas have occurred, they been donor cell origin when sought, Epstein‐Barr virus DNA has found in the tumor. A 21‐year‐old woman developed a poorly differentiated lymphocytic lymphoma 6 months bone for acute myeloid leukemia remission. Cyclosporin had used as immunosuppressant. chromosomal polymorphism demonstrated that tumor was host...
The effects of macrophage colony-stimulating factor (M-CSF or CSF-1) on the survival, proliferation, maturation and activation human blood monocytes were examined. M-CSF (100-1,000 U/ml) doubled number surviving after eight days in culture accelerated usual increase cell volume. Antiserum to abolished both these effects. There was no sizable 3H-thymidine incorporation over this time period. Of various factors tested, including gamma-interferon (gamma-IFN), interleukin (IL) 1 alpha,...
Abstract Medium conditioned by the monocyte‐like cell line GCT contains colony‐stimulating activity (CSA), a mediator of in vitro granulopoiesis. Also, medium (CM) erythroid‐enhancing (EEA), which can be demonstrated system utilizing either nonadherent marrow or blood mononuclear cells, erythropoietin (1–2 units/ml), and 20 ml/dl fetal calf serum. Under these conditions, CM enhances growth CFU‐E BFU‐E. Attempts were made to characterize molecular features EEA. Serum‐free was fractionated on...