A5102879423- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Microfinance and Financial Inclusion
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Innovation Policy and R&D
- FinTech, Crowdfunding, Digital Finance
- Cardiac pacing and defibrillation studies
- Regional Development and Policy
- COVID-19 and healthcare impacts
- Infective Endocarditis Diagnosis and Management
- Economic Growth and Productivity
- Global Financial Crisis and Policies
- Banking stability, regulation, efficiency
- Healthcare cost, quality, practices
- Cardiac Structural Anomalies and Repair
- Global Trade and Competitiveness
- Islamic Finance and Banking Studies
- Digital Platforms and Economics
- Economic Growth and Development
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Effects of Exercise
- Cruise Tourism Development and Management
- Global trade and economics
- Intellectual Property and Patents
Hospital Clínico San Carlos
2020-2025
Hospital Universitario 12 De Octubre
2025
Research Institute Hospital 12 de Octubre
2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2022-2024
Spanish National Centre for Cardiovascular Research
2024
Universidad Complutense de Madrid
2024
Dragonfly Therapeutics (United States)
2023
Cardiac damage staging has been postulated as a prognostic tool in patients undergoing transcatheter aortic valve replacement (TAVR). The aims of our study are (i) to validate cardiac systems previously described stratify with stenosis (AS), (ii) identify independent risk factors for 1-year mortality severe AS TAVR, and (iii) develop novel model compare its predictive performance that the above mentioned.Patients TAVR from 2017 2021 were included single-centre prospective registry....
Abstract Background Atrial fibrillation (AF) is a significant risk factor for the occurrence of stroke. Thromboembolic in patients with AF estimated using CHADS2 and CHA2DS2-VASc scales. In previous studies, correlation was observed between different echocardiographic parameters left atrium mechanics thromboembolic AF. Our main objective to evaluate association atrial strain measured events Methods Prospective cohort AF, who underwent transthoracic echocardiogram 3D wall-motion tracking...
Abstract Background and Aim Previous research has shown that women with primary mitral regurgitation (MPR) have worse surgical outcomes, compared men. Our aim was to evaluate whether cardiac damage prior intervention for severe MPR differs according gender. Methods Retrospective analysis of a prospective cohort patients PMR who underwent valve surgery in tertiary care center from 2014 2022. Echocardiographic parameters measured as well outcomes at 1-year follow-up (all-cause mortality heart...
Abstract Background and Purpose Current evidence shows that surgical aortic valve replacement (SAVR) transcatheter (TAVR) are comparable equally beneficial in patients with severe stenosis (AS) across different risk profiles. Our aim was to analyse potential differences cardiac damage related AS between undergoing SAVR those treated TAVR a contemporary cohort of AS. Methods Retrospective analysis prospective who underwent or tertiary care center from 2017 2022. Clinical echocardiographic...
Background/Objectives: Ventricular-arterial (VA) coupling, assessed via the TAPSE/PASP ratio, is a well-established prognostic marker in pulmonary arterial hypertension (PAH). However, transthoracic echocardiography (TTE) often fails to estimate artery systolic pressure (PASP). This study evaluated value of when PSAP was obtained both TEE and RHC their correlation. Methods: A prospective registry included 90 PAH patients (April 2021–May 2024). TTE were performed according clinical...
Background Myocardial strain is a promising marker for the detection of early left or right ventricular (LV RV) dysfunction in pediatric populations. The reference standard MR measurement myocardial tagging (MT); however, MT has limited clinical utility because additional acquisitions needed are time‐consuming. In contrast, MR‐feature tracking (FT) allows quantification from routinely acquired cine sequences. Studies providing values obtained with both FT and adolescents lacking. Purpose To...
European technology policy Research efforts in Europe matter countries do less research than Japan and the United States. But their lower level of effort has more to with smaller markets facing inventors productivity. substantial potential, that increasing most generates bigger income benefits there States by equivalent amounts. subsidies, enhanced patent protection, support for public research, higher educational achievement increased integration are alternative routes towards exploiting...
Interleukin-12 (IL-12) has emerged as one of the most potent cytokines for tumor immunotherapy due to its ability induce interferon γ (IFNγ) and polarize Th1 responses. Clinical use IL-12 been limited by a short half-life narrow therapeutic index.We generated monovalent, half-life-extended IL-12-Fc fusion protein, mDF6006, engineered retain high potency native while significantly expanding window. In vitro in vivo activity mDF6006 was tested against murine tumors. To translate our findings,...
Background Over the past years, information about crosstalk between epicardial adipose tissue (EAT) and cardiovascular system has emerged. Notably, in context of acute myocardial infarction (AMI), EAT might have a potential role pathophysiology ventricular structural changes function, clinical evolution patients. This study aims to assess impact on morpho-functional left ventricle (LV) outcome patients after an AMI. Methods We studied prospectively admitted our hospital with first episode...
Abstract Background and aim The MIDA scale is a prognostic tool for stratification of short- long-term mortality risk in patients with primary mitral regurgitation (PMR). this study to validate the (1) score our population PMR treated surgery. Methods Retrospective analysis prospective cohort who underwent valve surgery tertiary care center from 2014 2022. necessary parameters calculating Score (age, symptoms, atrial fibrillation, left diameter, right ventricular systolic pressure (RVSP),...