A5056984144- Cancer survivorship and care
- Nutrition and Health in Aging
- Frailty in Older Adults
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Surgical Treatments
- Childhood Cancer Survivors' Quality of Life
- Lymphatic System and Diseases
- Hemodynamic Monitoring and Therapy
- Gastric Cancer Management and Outcomes
- Hip and Femur Fractures
- Cardiovascular and exercise physiology
- Cardiac Health and Mental Health
- Optimism, Hope, and Well-being
- Clinical practice guidelines implementation
- Cancer-related cognitive impairment studies
- Physical Activity and Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Colorectal and Anal Carcinomas
- Intraperitoneal and Appendiceal Malignancies
- Acute Kidney Injury Research
- Radiomics and Machine Learning in Medical Imaging
- Aortic aneurysm repair treatments
- Ureteral procedures and complications
- Heart Failure Treatment and Management
Royal College of Surgeons in Ireland
2020-2024
Dublin City University
2016-2024
NHS Grampian
2024
Aberdeen Royal Infirmary
2024
University Hospital Southampton NHS Foundation Trust
2013-2021
University of Southampton
2013-2021
ORCID
2020
Southampton General Hospital
2019
Mater Misericordiae University Hospital
2018-2019
NIHR Southampton Biomedical Research Centre
2018
The EMPOWER trial aimed to assess the effects of a 9-week exercise prehabilitation programme on physical fitness compared with usual care control group. Secondary aims were investigate effect (1) psychological health; and (2) neoadjuvant chemoradiotherapy (NCRT) health.
In the United Kingdom, patients with locally advanced rectal cancer routinely receive neoadjuvant chemoradiotherapy. However, effects of this on physical fitness are unclear. This pilot study is aimed to investigate effect chemoradiotherapy objectively measured in vivo muscle mitochondrial function and whole-body fitness.We prospectively studied 12 who completed standardized chemoradiotherapy, recruited from a large tertiary centre, between October 2012 July 2013. All underwent...
The aim of this pilot study was to measure changes in physical activity level (PAL) variables, as well sleep duration and efficiency people with locally advanced rectal cancer (1) before after neoadjuvant chemoradiotherapy (CRT) (2) participating a pre-operative 6-week in-hospital exercise training programme, following CRT prior major surgery, compared usual care control group. We prospectively studied 39 consecutive participants (27 males). All completed standardised CRT: 23 undertook...
The standard treatment pathway for locally advanced rectal cancer is neoadjuvant chemoradiotherapy (CRT) followed by surgery. Neoadjuvant CRT has been shown to decrease physical fitness, and this associated with increased post-operative morbidity. Exercise training can stimulate skeletal muscle adaptations such as mitochondrial content improved oxygen uptake capacity, both of which are contributors fitness. aims the EMPOWER trial assess effects an in-hospital exercise programme on...
Advances in peri-operative oncological treatment, surgery and care have improved survival for patients with oesophagogastric cancers. Neoadjuvant cancer treatment (NCT) reduces physical fitness, which may reduce both compliance tolerance of NCT as well compromising post-operative outcomes. This is particularly detrimental a patient group where malnutrition common demanding. The aim this trial to assess the effect on fitness clinical outcomes comprehensive exercise training programme...
Introduction: Although the benefits of post-operative rehabilitation in cancer surgery are well established, role prehabilitation is less defined. Oesophagogastric cancers present a unique opportunity to study impact during neoadjuvant window, whether with chemotherapy or chemoradiotherapy (NCT) patients who frequently nutritionally depleted. This trial examines community-based exercise programme on patient fitness and after window. Methods: A pragmatic, randomized controlled multicentre was...
The majority of individuals living with and beyond cancer are not sufficiently active to achieve health benefits.The aim this study was explore individuals' experiences physical activity (PA) behavior across the journey ask identify strategies support habitual PA.An exploratory, descriptive, qualitative design used.Purposive sampling methods were used recruit who had been referred to, and/or participated in, a community-based exercise program or attending center. focus group discussions...
Abstract Background Pre-operative exercise training improves HR components of fitness and HRQoL following hospital-based programmes. Objective To assess compliance adherence a pragmatic community-based preoperative programme its effect on health-related (HR) quality life (HRQoL). Methods Thirty-two surgical oncological participants (15 prostate cancer 17 colorectal (CRC)) were recruited assessed to measure (strength functional capacity) HRQoL. An was prescribed in the time available prior...
In 2014 approximately 21,200 patients were diagnosed with oesophageal and gastric cancer in England Wales, of whom 37 % underwent planned curative treatments. Potentially surgical resection is associated significant morbidity mortality. For operable locally advanced disease, neoadjuvant chemotherapy (NAC) improves survival over surgery alone. However, NAC carries the risk toxicity a decrease physical fitness, which may turn influence subsequent clinical outcome. Lower levels fitness are...
Summary Neoadjuvant cancer treatment (NCT) reduces both physical fitness and activity (PA) levels, which can increase the risk of adverse outcomes in patients. This study aims to determine effect exercise prehabilitation on PA sedentary behavior (SB) patients undergoing NCT surgery for esophagogastric malignancies. is a randomized pragmatic controlled multi-center trial conducted across three Irish hospitals. Participants were aged ≥18 years scheduled esophagectomy or gastrectomy planned...
Neoadjuvant cancer treatment is associated with improved survival following major oesophagogastric surgery. The impact of neoadjuvant chemo/chemoradiotherapy on physical fitness and operative outcomes however unclear. This study aims to investigate the post-operative mortality.Patients scheduled for surgery were recruited a prospective, blinded, multi-centre, observational cohort study. Primary changes in chemo/chemoradiotherapy, measured using cardiopulmonary exercise testing its...
Men with a newly diagnosed prostate cancer are often treated by surgery. The time window between diagnosis and surgery causes high levels of uncertainty stress, which negatively impact quality life (QoL). We previously reported larger intervention pilot study demonstrated that participation in community-based pre-operative exercise programme significantly improved physical fitness health-related men prior to aim the current was get an insight into men's perceptions wellbeing QoL following...