A5062157181- Lung Cancer Treatments and Mutations
- Advanced Chemical Sensor Technologies
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Biosensors and Analytical Detection
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Gas Sensing Nanomaterials and Sensors
- Head and Neck Cancer Studies
- HER2/EGFR in Cancer Research
- Peptidase Inhibition and Analysis
- Analytical Chemistry and Sensors
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- SARS-CoV-2 and COVID-19 Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Analytical Chemistry and Chromatography
- Brain Metastases and Treatment
- Lymphoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
Samsung Medical Center
2014-2025
Sungkyunkwan University
2014-2025
Bucheon University
2017-2023
Soonchunhyang University
2017-2023
Yonsei University Health System
2023
iSense (United States)
2010-2020
Metabolomx (United States)
2014-2018
Specific Technologies (United States)
2013-2017
Zero to Three
2016
Hallym University Dongtan Sacred Heart Hospital
2016
Approximately 10% of patients with epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC) harbor uncommon mutations. Here, we report the efficacy and safety osimertinib in NSCLC harboring EGFR
Immune checkpoint inhibitors targeting programmed death protein 1 (PD-1) receptor and its ligand, PD-L1, have recently led to significant durable improvements in the clinical outcomes of some types cancers including lung cancer.Pembrolizumab was approved by US FDA for treatment advanced or metastatic NSCLC whose disease has progressed after other treatments with tumors that express PD-L1. In phase I KEYNOTE-001 trial, overall response rate (ORR) 19.4%, median progression-free survival (PFS)...
A low-cost yet highly sensitive colorimetric sensor array for the detection and identification of toxic industrial chemicals (TICs) has been developed. The consists a disposable cross-responsive nanoporous pigments whose colors are changed by diverse chemical interactions with analytes. Clear differentiation among 20 different TICs easily achieved at both their IDLH (immediately dangerous to life or health) concentration within 2 min exposure PEL (permissible limit) 5 no errors...
A colorimetric sensor array has been developed for the rapid and sensitive detection of 20 toxic industrial chemicals (TICs) at their PELs (permissible exposure limits). The color changes in an chemically responsive nanoporous pigments provide facile identification TICs with error rate below 0.7%.
A disposable, low-cost colorimetric sensor array has been created by pin-printing onto a hydrophilic membrane 16 chemically responsive nanoporous pigments that are comprised of indicators immobilized in an organically modified silane (ormosil). The used to detect and identify 14 different natural artificial sweeteners at millimolar concentrations, as well commonly individual-serving sweetener packets. shown excellent reproducibility long shelf life optimized work the biological pH regime.
Oropharyngeal squamous cell carcinoma (OSCC) has been recognized as an immunosuppressive disease. Various mechanisms have proposed for immune escape, including dysregulation of checkpoints such the PD-1:PD-L1 pathway. We investigated expression programmed death-ligand 1 (PD-L1) in HPV-negative and HPV-positive OSCC to determine its prevalence prognostic relevance.Using immunohistochemistry, 133 cases were evaluated PD-L1. Formalin-fixed paraffin-embedded tumor samples stained with monoclonal...
Molecular recognition of sugars and a practical method to detect discriminate among large number such similar analytes remain substantial scientific challenges. We report here low-cost, simple colorimetric sensor array capable identification quantification related compounds. Fifteen different monosaccharides, disaccharides, artificial sweeteners were differentiated without error in 80 trials. Limits detection at pH 7.4 for glucose <1 mM, which is below physiologically important levels.
A general method has been developed for the preparation of microspheres nanoporous pigments, their formulation into chemically responsive pigment inks, and printing these inks as colorimetric sensor arrays. Using an ultrasonic-spray aerosol-gel synthesis from dyes common silica precursors, 16 different have prepared characterized. New arrays created by pigments primary elements; successfully tested detection, identification, quantitation toxic aliphatic amines. Among 11 structurally similar...
BACKGROUND Fibroblast growth factor receptor 1 ( FGFR1 ) amplification is a potential driving oncogene in squamous cell cancer (SCC) of the lung. The current phase 2 study evaluated efficacy and tolerability dovitinib, an FGFR inhibitor, patients with advanced SCC METHODS Patients pretreated lung whose tumors demonstrated > 5 copies by fluorescence situ hybridization were enrolled. Dovitinib at dose 500 mg was administered orally, once daily, on days to every week, followed off. primary...
// Ji Yun Lee 1, * , Kyunghee Park 2, Sung Hee Lim 1 Hae Su Kim Kwai Han Yoo Ki Sun Jung Haa-Na Song Mineui Hong 3 In-Gu Do TaeJin Ahn 2 Se Kyung 4 Soo Youn Bae Seok Won Jeong Eon Jin Nam Duk-Hwan 5 Hyun 6 Ji-Yeon Young-Hyuck Im Yeon Division of Hematology-Oncology, Department Medicine, Samsung Medical Center, Sungkyunkwan University School Seoul, Korea Genomic Institute, Biological Research Center Companion Diagnostics, Innovative Cancer Medicine Surgery, Molecular Cell Biology, Biomedical...
Abstract The biology of breast cancer brain metastasis (BCBM) is poorly understood. We aimed to explore genes that are implicated in the process primary (BC). NanoString nCounter Analysis covering 252 target was used for comparison gene expression levels between 20 BCs relapsed and 41 BCBM samples. PAM50-based intrinsic subtypes such as HER2-enriched basal-like were clearly over-represented BCBM. A panel 22 found be significantly differentially expressed BC Five these genes, CXCL12 , MMP2...
We report the successful use of colorimetric arrays to identify chemical warfare agents (CWAs). Methods were developed interpret and analyze a 73-indicator array with an entirely automated workflow. Using cross-validated first-nearest-neighbor algorithm for assessing detection identification performances on 632 exposures, at 30 min postexposure we report, average, 78% correct identification, 86% class-level 96% red light/green light (agent versus non-agent) detection. Of 174 total...
Summary Forty-two patients with chronic lymphocytic leukaemia (CLL), serum IgG levels < 5.5 g/l and a history of two or more recent infections, were randomized to receive infusions 18 g human intravenous immunoglobulin (IVIg) albumin placebo every three weeks. During the 12 month study 122 infections documented but only four associated neutropenia. Ten (24%) 3.0 g/1 experienced 65% infections. In response IVIg there immediate accumulative increases in an decrease total serious If further...
The development of a low-cost, simple colorimetric sensor array capable the detection and identification toxic gases is reported. This technology uses disposable printed porous pigments in which metalloporphyrins chemically-responsive dyes are immobilized matrix organically modified siloxanes (ormosils) on membrane. printing ormosil into membrane highly uniform does not lessen porosity membrane, as shown by scanning electron microscopy. When exposed to an analyte, these undergo reactions...
ABSTRACT Sepsis is a medical emergency demanding early diagnosis and tailored antimicrobial therapy. Every hour of delay in initiating effective therapy measurably increases patient mortality. Blood culture currently the reference standard for detecting bloodstream infection, multistep process which may take one to several days. Here, we report novel paradigm earlier detection simultaneous identification pathogens spiked blood cultures by means metabolomic “fingerprint” volatile mixture...
A colorimetric sensor array is a high-dimensional chemical that cheap, compact, disposable, robust, and easy to operate, making it good candidate technology detect pathogenic bacteria, especially potential bioterrorism agents like Yersinia pestis Bacillus anthracis which feature on the Center for Disease Control Prevention's list of biothreats. Here, was used continuously monitor volatile metabolites released by bacteria in solid media culture an Advisory Committee Dangerous Pathogen...
Monocarboxylate transporters (MCTs) play a major role in up-regulation of glycolysis and adaptation to acidosis. However, the MCTs gastric cancer (GC) is not fully understood. We investigated potential utilization new therapy for GC. characterized expression patterns MCT isoforms 1, 2, 4 GC through vitro vivo tests using siRNA targeting MCTs. In cell lines, MCT1, were up-regulated with different levels; MCT1 MCT4 more widely expressed lines compared MCT2. Inhibition by or AR-C155858 reduced...