A5022700261- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Myasthenia Gravis and Thymoma
- Multiple Myeloma Research and Treatments
- Cancer Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Advanced Breast Cancer Therapies
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Fungal Infections and Studies
- Vascular Tumors and Angiosarcomas
- Breast Cancer Treatment Studies
- Lung Cancer Research Studies
- Viral-associated cancers and disorders
- Prostate Cancer Treatment and Research
- Acute Myeloid Leukemia Research
- Quinazolinone synthesis and applications
- Head and Neck Cancer Studies
- Cutaneous lymphoproliferative disorders research
Seoul Veterans Hospital
2016-2024
Sungkyunkwan University
2015-2017
Samsung Medical Center
2015-2017
Hanyang University
2012-2014
Hanyang University Guri Hospital
2013-2014
Anyang University
2013
Oropharyngeal squamous cell carcinoma (OSCC) has been recognized as an immunosuppressive disease. Various mechanisms have proposed for immune escape, including dysregulation of checkpoints such the PD-1:PD-L1 pathway. We investigated expression programmed death-ligand 1 (PD-L1) in HPV-negative and HPV-positive OSCC to determine its prevalence prognostic relevance.Using immunohistochemistry, 133 cases were evaluated PD-L1. Formalin-fixed paraffin-embedded tumor samples stained with monoclonal...
// Ji Yun Lee 1, * , Kyunghee Park 2, Sung Hee Lim 1 Hae Su Kim Kwai Han Yoo Ki Sun Jung Haa-Na Song Mineui Hong 3 In-Gu Do TaeJin Ahn 2 Se Kyung 4 Soo Youn Bae Seok Won Jeong Eon Jin Nam Duk-Hwan 5 Hyun 6 Ji-Yeon Young-Hyuck Im Yeon Division of Hematology-Oncology, Department Medicine, Samsung Medical Center, Sungkyunkwan University School Seoul, Korea Genomic Institute, Biological Research Center Companion Diagnostics, Innovative Cancer Medicine Surgery, Molecular Cell Biology, Biomedical...
Monocarboxylate transporters (MCTs) play a major role in up-regulation of glycolysis and adaptation to acidosis. However, the MCTs gastric cancer (GC) is not fully understood. We investigated potential utilization new therapy for GC. characterized expression patterns MCT isoforms 1, 2, 4 GC through vitro vivo tests using siRNA targeting MCTs. In cell lines, MCT1, were up-regulated with different levels; MCT1 MCT4 more widely expressed lines compared MCT2. Inhibition by or AR-C155858 reduced...
KRAS mutations are common in colorectal cancer (CRC). The role of mutation status as a prognostic factor remains controversial, and most large population-based cohorts usually consist patients with non-metastatic CRC. We evaluated the impact on time to recurrence (TTR) overall survival (OS) metastatic CRC who underwent curative surgery perioperative chemotherapy.Patients resection for primary synchronous metastases were retrospectively collected single institution during 6 year period...
Abstract Purpose: In this phase Ib/II study, we aimed to assess the safety and efficacy of afatinib plus nimotuzumab (N) in advanced non–small cell lung cancer (NSCLC) patients with acquired resistance gefitinib or erlotinib. Experimental Design: Ib stage, received (40 mg 30 once daily) (100 200 weekly) for 28-day cycles determine recommended II dose (RPIID). The RPIID was evaluated stage. Results: total, 50 were enrolled (13 37 II). first dose-finding cohort (afatinib 40 100 mg), one...
Papillary thyroid carcinomas (PTCs) frequently involve genetic alterations. The objective of this study was to investigate alterations and further explore the relationships between these clinicopathological characteristics in a high-recurrence risk (node positive, N1) PTC group.Tumor tissue blocks were obtained from 240 surgically resected patients with histologically confirmed stage III/IV (pT3/4 or PTCs. We screened gene fusions using NanoString's nCounter technology mutational analysis...
Background/Aims Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy that typically presents in the form of skin manifestations with or without lymph node and bone marrow involvement. Given its rarity recent recognition as distinct pathological entity, no standard treatment exists for this aggressive disease prognosis particularly dismal. Methods We retrospectively analyzed clinical features outcomes patients who were diagnosed BPDCN between 2000 2014....
The macrophage inflammatory protein 1α (MIP-1α) is anticipated to have a role in extranodal natural killer (NK)/T-cell lymphoma (ENKTL) because the expression of MIP-1α related Epstein–Barr virus (EBV) latency EBV-related non-Hodgkin cells. Thus, we measured serum level 69 patients with ENKTL using frozen samples that were archived at diagnosis. As was not detectable 19 (range: 0–24.37 pg/mL), dichotomized into positive (n = 50) and negative 19) groups according presence serum....
Purpose: To provide a comprehensive analysis of ICI usage and treatment outcomes in elderly Korean veterans with stage IV NSCLC. Methods: Patients diagnosed NSCLC between 2016 2021 were included, three cohorts derived according to the type received. Thereafter, clinical characteristics survival compared. Results: Of 180 patients (median age, 76 years) included this study, 49 (27.7%), 61 (33.9%), 70 (38.9%) received pembrolizumab, nivolumab, atezolizumab, respectively, 19.4%, 36.1%, 34.4% had...
Colonic wall thickening is frequently encountered in various conditions, from acute or chronic inflammatory disease to colorectal carcinoma. may be accompanied by calcifications mucinous adenocarcinoma of the colon, leiomyosarcoma schistosomiasis japonica, and phlebosclerotic colitis. Phlebosclerotic colitis a rare entity ischemic associated with sclerosis fibrosis mesenteric veins. Although its development usually insidious, and, thus diagnosis can delayed, characteristic findings are veins...
The purpose of this study was to assess the tumor characteristics and long-term clinical outcomes adjuvant treatments after surgery with a curative aim for patients breast cancer who are 65 years older.Patients underwent from 2000 2009 were analyzed (n=4,388). Tumor survival outcome compared by dividing into two age groups (< ≥ old). Kaplan-Meier method used comparison rates log-rank test, Cox regression model examine effect variables.Among 4,388 invasive cancer, 317 (7.2%) or older median...
Duodenal variceal bleeding in patients with portal hypertension due to cirrhosis or other causes is uncommon. We report on a case of 55-year-old male an ectopic rupture at the distal fourth part duodenum who presented massive hematochezia and shock. Shortly after achievement hemodynamic stability, limitation endoscopic procedure, we initially attempted find focus by abdominal computed tomography, which showed tortuous duodenal varices that drained into left gonadal vein. He was treated...
A rheo-diecasting using a high-strength Al alloy has been investigated to estimate its applicability the manufacturing of automobile suspension parts replace hot-forging process. The used in present study was based on Al–Si–Mg system, which developed recently for high mechanical performance rheo-diecasting. Two important aspects were considered this effort use practical applications: (i) optimization conditions semi-solid slurries and (ii) proper mold design Electromagnetic stirring melt...
The aim of this retrospective study was to evaluate the clinical outcomes reduced dose, biweekly docetaxel chemotherapy for Korean patients with castrate-resistant prostate cancer (CRPC). We retrospectively reviewed medical records 48 metastatic CRPC who were treated a regimen (intravenous 40 mg/m2 on day 1 plus prednisolone 5 mg twice daily) between 2012 and 2015 at Samsung Medical Center (Seoul, Korea). Prior adoption in Oct 2013, our institutional standard 75 every 3 weeks (n = 24). After...
The purpose of this study was to investigate the clinicopathologic features and prognostic factors affecting outcome in patients with isolated locoregional recurrence breast cancer (ILRR).We retrospectively analyzed medical records 104 who were diagnosed ILRR underwent curative surgery from January 2000 December 2010 at Samsung Medical Center.Among patients, 43 (41%) total mastectomy 61 (59%) breast-conserving for primary cancer. median time initial operation 35.7 months (4.5-132.3 months)....
Background Metastatic breast cancer (MBC) remains a devastating and incurable disease. Over the past decade, implementation of clinical trials both with without molecular targeted therapeutics has impacted daily treatment patients MBC. In this study, we determine whether including MBC in affects outcomes. Methods We retrospectively reviewed data for total 863 diagnosed initial or recurrent (after receiving adjuvant systemic treatments following surgery) metastatic disease between January...
e14003 Background: Human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma of head and neck is an immunosuppressive malignancy. In (HNSCC), various mechanisms have been proposed for the immune escape including checkpoint receptors such as PD-1/PD-L1. this study, we investigated expression PD-L1 in HPV-negative HPV-positive cancer to determine its prevalence prognostic relevance. Methods: The was evaluated by immunohistochemistry 135 specimens cancer. A minimum 20 % tumor...