A5100644047- Gastric Cancer Management and Outcomes
- Gene Regulatory Network Analysis
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Tissue Engineering and Regenerative Medicine
- Computational Drug Discovery Methods
- Biochemical Analysis and Sensing Techniques
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Wnt/β-catenin signaling in development and cancer
- Fibroblast Growth Factor Research
- vaccines and immunoinformatics approaches
- NF-κB Signaling Pathways
- Melanoma and MAPK Pathways
- Genetic Associations and Epidemiology
- 14-3-3 protein interactions
- Circular RNAs in diseases
- Head and Neck Cancer Studies
Guangzhou University of Chinese Medicine
2024
Xinxiang Medical University
2021-2024
Henan Psychiatric Hospital
2024
Sir Run Run Shaw Hospital
2013-2023
Zhejiang University
2013-2023
Sichuan University
2023
State Key Laboratory of Oral Diseases
2023
Dalian Medical University
2015-2022
Second Affiliated Hospital of Dalian Medical University
2015-2022
Guangxi Medical University
2022
Background The dose-dependent toxicities of doxorubicin (DOX) limit its clinical applications, particularly in drug-resistant cancers, such as liver cancer. In this study, we investigated the role quercetin on antitumor effects DOX cancer cells and ability to provide protection against DOX-mediated damage mice. Methodology Results MTT Annexin V/PI staining assay demonstrated that selectively sensitized DOX-induced cytotoxicity while protecting normal cells. increase apoptosis hepatoma by was...
Doxorubicin-based chemotherapy induces cardiotoxicity, which limits its clinical application. We previously reported the protective effects of quercetin against doxorubicin-induced hepatotoxicity. In this study, we tested on expression Bmi-1, a protein regulating mitochondrial function and ROS generation, as mechanism underlying quercetin-mediated protection cardiotoxicity.
MicroRNAs (miRNAs) exhibit essential regulatory functions related to cell growth, apoptosis, development and differentiation. Dysregulated expression of miRNAs is associated with a wide variety human diseases. As such miRNA signatures are valuable as biomarkers for disease making treatment decisions. Hepatitis B virus (HBV) major risk factor hepatocellular carcinoma (HCC). Here we screened in chronic HBV HCC. To determine the HCC occurrence infection, analyzed global profiles 12 pairs...
Abstract Purpose: Inflammatory cytokines have been implicated in the progression of head and neck squamous cell carcinoma (HNSCC). Herein we investigate mechanisms by which interleukin-1β (IL-1β) might contribute to Epithelial-Mesenchymal Transition (EMT) HNSCC. Experimental Design: We evaluated effect IL-1β on molecular events EMT surgical specimens HNSCC lines. examined correlation with tumor histologic features, a SCID xenograft model was used assess effects Snail overexpression. Results:...
Scope Short‐chain fatty acid sodium butyrate (NaB) is the byproduct of bacterial anaerobic fermentation dietary fiber in colon, and has been shown to have an antitumor effect on colorectal cancer (CRC). The miR‐200 family a key regulator epithelial‐mesenchymal transition (EMT). We investigate role miR‐200s expression cell migration NaB‐treated CRC cells. Methods results HCT116 LOVO cells treated with NaB depicted reduced proliferation, enhanced apoptosis, cycle arrest. inhibited wound...
Berbamine, a natural compound from the plant Berberis amurensis, is traditional Chinese medicine mainly used in stimulating normal hematopoiesis clinic. Our previous studies demonstrated that berbamine has anti-leukemia activity. In this study, we investigated anticancer activity of against human hepatocellular carcinoma (HCC) HepG2 cells vitro and vivo. Berbamine treatment decreased cell growth dose-dependent manner with an IC50 value 34.5 ± 0.5 μM. Flow cytometric analysis apoptosis using...
pH-responsive nanofibers are obtained by the self-assembly of camptothecin prodrug and surface-coating, which can efficiently enter cancer cells <italic>in vitro</italic> penetrate deep into tumor tissue vivo</italic>.
Food intake influences neurofunction via the gut microbiota-brain axis. Monounsaturated fatty acid (MUFA) consumption is highly associated with neuroprotection; mechanism behind effects of olive oil and camellia on microbiota remains unclear. In this study, objective was to compare neuroprotective role oleic acid-rich against AlCl3-induced mild cognitive impairment (MCI) in rats. Morris water maze tests revealed that learning memory capacities improved rats subjected administration better...
A central challenge in systems biology today is to understand the network of interactions among biomolecules and, especially, organizing principles underlying such networks. Recent analysis known networks has identified small motifs that occur ubiquitously, suggesting larger might be constructed manner electronic circuits by assembling groups these smaller modules. Using a unique process-based approach analyzing networks, we show for two cell-cycle each contains giant backbone motif spanning...
To determine the role of ZEB1 in inflammation-induced promotion epithelial-mesenchymal transition (EMT) head and neck squamous cell carcinoma (HNSCC).A molecular biology study. Real-time quantitative reverse-transcriptase polymerase chain reaction (RT-PCR), Western blot analysis, immunohistochemical staining human HNSCC tissue sections were used to how inflammation affects transcriptional repressor, ZEB1.An academic hospital laboratory.Relative RNA levels determined by RT-PCR, protein...
Radiation‐induced oral mucositis is a major adverse event of radiotherapy. Severe may cause unwanted interruption in radiotherapy and reduce long‐term survival cancer patients receiving radiotherapy, but until now, there have been no effective options for preventing radiation‐induced mucositis. Quercetin flavonoid that widely found food species has anti‐inflammatory, antioxidant, anticancer activities. In this study, we investigated new role quercetin exerted preventive effects against...
Pancreatic ductal adenocarcinoma (PDAC) is a leading causes of cancer mortality worldwide. Currently, laparoscopic pancreatic resection (LPR) extensively applied to treat benign and low-grade diseases related the pancreas. The viability safety LPR for PDAC needs be understood better. Laparoscopic distal pancreatectomy (LDP) pancreaticoduodenectomy (LPD) are two main surgical approaches PDAC. We performed separate propensity score matching (PSM) analyses assess oncological outcomes by...
Diabetic chronic wounds present a formidable challenge in clinical management, lacking effective treatment options. Mesenchymal stem cell (MSC) transplantation has emerged as promising therapy for tissue repair and regeneration. However, transplanted MSCs often undergo rapid apoptosis, giving rise to heterogeneous extracellular vesicles (EVs), including apoptotic bodies (apoBDs) small (apoSEVs). The potential stimulatory role of these EVs diabetic wound healing remains unknown.In this study,...
Sugarcane (Saccharum officinarum L.) is an economically important crop, mainly due to the production of sugar and biofuel (Azevedo RA, Carvalho RF, Cia MC, & Gratão PL, Trop Plant Biol 4:42-51, 2011). Grown in tropical subtropical countries, sugarcane a highly polyploid plant with up ten copies each chromosome, which increases difficulties genome assembly genetic, physiologic biochemical analyses. The increasing demands cost harvest require varieties can shed their leaves during maturity...
Gradiently degraded cytostatic-loaded electrospun polyester scaffolds as potential self-removing ureteral stents prevent the recurrence of urothelial carcinoma.
Liver is the most common metastatic site for colorectal cancer (CRC), there no satisfied approach to treat CRC liver metastasis (CRCLM). Here, we investigated role of a polycomb protein BMI-1 in CRCLM. Immunohistochemical analysis showed that expression metastases was upregulated and associated with T4 stage, invasion depth right-sided primary tumor. Knockdown high HCT116 LOVO cells repressed migratory/invasive phenotype reversed epithelial–mesenchymal transition (EMT), while overexpression...