A5101898353- Phosphodiesterase function and regulation
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- Smoking Behavior and Cessation
- Asthma and respiratory diseases
- Mast cells and histamine
- Pharmacological Effects of Natural Compounds
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Immune Response and Inflammation
- Regulation of Appetite and Obesity
- Phytochemicals and Antioxidant Activities
- Biochemical Analysis and Sensing Techniques
- Pancreatic function and diabetes
- Sleep and Wakefulness Research
- Polysaccharides and Plant Cell Walls
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Obesity, Physical Activity, Diet
- Pain Management and Treatment
- Enhanced Recovery After Surgery
- Zebrafish Biomedical Research Applications
- Ginger and Zingiberaceae research
- Cancer, Lipids, and Metabolism
Chung-Ang University
2019-2025
Korea Research Institute of Bioscience and Biotechnology
2020-2024
Cheongju University
2023
Bridge University
2021
University Research Co (United States)
2021
George Washington University Hospital
2021
Catholic Kwandong University
2021
Chungbuk National University
2020
Korea Institute of Science and Technology
2020
University of Arkansas at Fayetteville
2018
Smoking onset has 4 levels, with a "susceptibility" level preceding early experimentation. This study assessed the predictive validity of smoking susceptibility in longitudinal nationally representative sample 4,500 adolescents who at baseline reported never having puffed on cigarette. At follow-up years later, 40% had experimented smoking, and 8% established habit. Baseline to defined as absence firm decision not smoke, was stronger independent predictor experimentation than presence...
Paclitaxel is an anti-microtubule agent that has been shown to induce cell death in gastric cancer. However, the detailed mechanism of action unclear. In this study, we reveal paclitaxel-induced involves mitotic catastrophe, autophagy and apoptosis AGS cells. induced intrinsic by activating caspase-3, caspase-9 PARP. addition, significant increase marker LC3B-II, together with Atg5, class III PI3K Beclin-1, down-regulation p62 following paclitaxel treatment verified autophagy. Further...
Purpose.: To investigate the protective effect of rapamycin against alkali burn-induced corneal damage in mice. Methods.: BALB/c mice were treated with 0.1 N NaOH to cornea for 30 seconds. Corneal neovascularization and opacity clinically evaluated at 1, 2, 4 weeks after chemical burn injury. Rapamycin was delivered topically right eyes (1 mg/mL) injected intraperitoneally (0.2 mg/kg) once a day. Concentrations interleukin-6 (IL-6) transforming growth factor-beta1 (TGF-β1) measured by...
Abstract The E6 and E7 proteins of specific subtypes human papillomavirus (HPV), including HPV 16 18, are highly associated with cervical cancer as they modulate cell cycle regulation. aim this study was to investigate the potential antitumor effects a messenger RNA‐HPV therapeutic vaccine (mHTV) containing nononcogenic proteins. To achieve this, C57BL/6j mice were injected via both intramuscular subcutaneous routes, resulting evaluated. mHTV immunization markedly induced robust T...
Background Panax ginseng Meyer ( P. ginseng) is a well-known herb of traditional Chinese medicine that has been used to revitalize the body and mind. A recent study revealed exhibits neuroprotective activity against brain damage. also enhances cognitive function. However, protective effects berry hepatic encephalopathy (HE) have not yet studied. We investigated effect ultrasonication-processed GBE (UGBE) compared on mild bile duct ligation (MBDL) verify HE. Methods After ultrasonication,...
Highlights•The role of LHAGABA neurons on macaque's naturalistic eating behavior was investigated•Chemogenetic activation increased goal-directed behaviors, mainly for palatable food•PET and MRS functionally validated chemogenetic activation•Rs-fMRI revealed LHA-frontal FC, with decreased FC within frontal corticesSummaryMaladaptive feeding is the primary cause modern obesity. While causal influence lateral hypothalamic area (LHA) has been established in rodents, there currently no...
Hypoxia-inducible factor (HIF), an important mediator of hypoxia response, is implicated in tumorigenesis the setting pseudohypoxia, such as inactivation von Hippel-Lindau tumor suppressor protein (pVHL), leading to development and progression clear cell renal carcinoma (ccRCC). Targeting downstream molecules HIF pathway, vascular endothelial growth (VEGF), has led improvement clinical outcome for patients with advanced ccRCC, but therapy thus far been limited by eventual resistance...
Abstract Myocardial infarction (MI) damage induces various types of cell death, and persistent ischemia causes cardiac contractile decline. An effective therapeutic strategy is needed to reduce myocardial death induce recovery. Therefore, studies on molecular genetic biomarkers MI, such as microRNAs (miRs), have recently been increasing attracting attention due the ideal characteristics miRs. The aim present study was discover novel causative factors MI using multiomics-based functional...
A nested case-control study within the Beaverlodge Uranium Miners Cohort was undertaken to assess any possible contribution of confounding by smoking and other mining experience risk estimate derived from original cohort study. Next kin have been interviewed for 46 lung cancer cases 95 controls enrolled in Study who died between 1950 1980. Confounding cigarette appears unlikely contributed relative coefficient exposure Rn decay products parent Data are consistent with a multiplicative model,...
Summary This study aimed to determine whether texture perception and acceptance of cooked rice could differ with cultural background, especially between Korean American participants. Participants evaluated eight samples respect intensities textural attributes such as visual stickiness, hardness, stickiness chewiness. also rated the acceptability familiarity those samples. Results showed that Americans gave higher ratings chewiness, while Koreans hardness than their counterpart. For...
Eupatilin is known to possess anti-apoptotic, anti-oxidative, and antiinflammatory properties. We report here that eupatilin has a protective effect on the ethanol-induced injury in rats. Sprague-Dawley rats were divided into 6 groups: control, vehicle, silymarin, 10 mg/kg, 30 100 mg/kg. Plasma levels of aspartate aminotransferase (AST) alanine (ALT) analyzed determine extent liver damage. Total cholesterol (TC) triglycerides (TG) level steatosis. Malondialdehyde level, superoxide dismutase...
Objective Asthma is a chronic inflammatory disease that can lead to severe problems with the respiratory system. This study aimed evaluate suppression of allergic airway inflammation an asthma murine model by 3-isobutyl-1-methylxanthine (IBMX), which non-specific cyclic nucleotide phosphodiesterase (PDE) inhibitor. Methods Allergic lung was evoked ovalbumin (OVA) alone or co-exposure lipopolysaccharide (LPS) in model. Results Compared OVA alone-treated control, LPS significantly enhanced...
Gastric adenocarcinoma is among the top causes of cancer-related death and one most commonly diagnosed carcinomas worldwide. Benzyl isothiocyanate (BITC) has been reported to inhibit gastric cancer metastasis. In our previous study, BITC induced apoptosis in AGS cells. The purpose present study was investigate effect on autophagy mechanism First, cells were treated with 5, 10, or 15 μM for 24 h, followed by an analysis mechanism. expression level proteins involved different steps autophagy,...
Background Intraocular cytomegalovirus (CMV) infections, including endotheliitis and retinitis, have been reported to threaten the host's vision. These infections treated with systemic or intravitreal GCV injection. Intracameral injection can be an effective treatment option that avoids side effects. The cytotoxic effect of ganciclovir (GCV) on cultured human corneal endothelial cells (HCECs) was evaluated. Methods HCECs were exposed various concentrations (0–20 mg/ml) (Cytovene®). Cell...
Hydrogen sulfide is well-known to exhibit anti-inflammatory and cytoprotective activities, also has protective effects in the liver. This study aimed examine effect of hydrogen rats with hepatic encephalopathy, which was induced by mild bile duct ligation. In this rat model, ducts were mildly ligated for 26 days. Rats treated final 5 days sodium hydrosulfide (NaHS). NaHS (25 µmol/kg), 0.5% carboxymethyl cellulose, or silymarin (100 mg/kg) administered intraperitoneally once per day...
Asthma is a well-known bronchial disease that causes inflammation, narrowing of the tubes, and mucus secretion, leading to blockade. In this study, we investigated association between phosphodiesterase (PDE), specifically PDE1, asthma using 3-isobutyl-1-methylxanthine (IBMX; non-specific PDE inhibitor) vinpocetine (Vinp; PDE1 inhibitor). Balb/c mice were randomized five treatment groups: control, ovalbumin (OVA), OVA + IBMX, Vinp, dexamethasone (Dex). All sensitized challenged with OVA,...
This study aimed to examine the effects of vinpocetine on atopic dermatitis (AD) by administering it via oral, intraperitoneal, and topical routes HR-1 hairless mice. AD was induced in mice for five weeks with ovalbumin, administered twice daily through each route administration two after induction AD. Vinpocetine (20, 10, 2 mg/kg) routes, respectively. The suppressed increase serum immunoglobulin (Ig) E IgG1 levels production interleukin (IL)-4 IL-13-cytokines linked T helper cells skin...
Chronic stress can cause the gastrointestinal disorders characterized by an altered bowel movement and abdominal pain. Studies have shown that Humulus japonicus extract (HJE) has anti-inflammatory antidiarrheal effects, Phragmites rhizoma (PEP) antioxidative antistress effects. The present study aimed to investigate possible effects of HJE PEP in rat models with stress-induced dysfunctions. rats were exposed water avoidance (WAS, 1 h/day) for 10 days induce disorders. We found WAS...
Context Pinus densiflora Siebold & Zucc. (Pinaceae) needle extracts ameliorate oxidative stress, but research into their anti-inflammatory effects is limited.Objective To investigate antioxidant and of a needles (PINE) ethanol extract in vitro vivo.Materials methods We measured levels reactive oxygen species (ROS), superoxide dismutase (SOD) inflammatory mediators lipopolysaccharide (LPS)-stimulated RAW264.7 cells at various PINE concentrations (25, 50 100 μg/mL; 6.25, 12.5 25 μg/mL for...
Recent longitudinal evidence suggests that approximately 34% of all new tobacco experimentation occurs because advertising and promotions. Based on this figure, in paper we estimate the long-term impact mortality morbidity, as well economic medical costs associated with smoking is attributable to cigarette promotions United States. This study used several data sources, including Teenage Attitudes Practices Survey (TAPS), 1993 1996 Adolescent California Tobacco Surveys (CTS), Food Drug...