A5026881629- Seaweed-derived Bioactive Compounds
- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- Renin-Angiotensin System Studies
- Nitric Oxide and Endothelin Effects
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Endometriosis Research and Treatment
- Cancer Research and Treatments
- Renal and related cancers
- Aquaculture disease management and microbiota
- Renal and Vascular Pathologies
- Algal biology and biofuel production
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Acute Lymphoblastic Leukemia research
- Phytochemistry and Bioactive Compounds
- Cancer Cells and Metastasis
- Marine Sponges and Natural Products
- Echinoderm biology and ecology
- Chronic Myeloid Leukemia Treatments
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Magnesium in Health and Disease
- Tuberous Sclerosis Complex Research
The University of Texas Health Science Center at San Antonio
2008-2024
The University of Texas at San Antonio
2023-2024
One Cell Systems (United States)
2023
Annamalai University
2008-2019
University of Oklahoma Health Sciences Center
2013
Abstract Bromodomain‐containing protein 4 (BRD4) is overexpressed and functionally implicated in various myeloid malignancies. However, the role of BRD4 normal hematopoiesis remains largely unknown. Here, utilizing an inducible Brd4 knockout mouse model, we find that deletion ( Δ/Δ ) hematopoietic system impairs stem cell (HSC) self‐renewal differentiation, which associates with cycle arrest senescence. ATAC‐seq analysis shows increased chromatin accessibility stem/progenitor cells...
In this study we have identified POLθ-S6K-p62 as a novel druggable regulator of radiation response in prostate cancer. Despite significant advances delivery, radiotherapy continues to negatively affect treatment outcomes and quality life due resistance late toxic effects the surrounding normal tissues such bladder rectum. It is essential develop new effective strategies achieve better control tumor. We found that ribosomal protein S6K (RPS6KB1) elevated human tumors, contributes radiation....
Pancreatic cancer (PC) remains the fourth leading cause of death with an unacceptable survival that has remained relatively unchanged over past 25 years. The presence occult or clinical metastases at time diagnosis together lack effective chemotherapies pose a dire need for designing new and targeted therapeutic deliverables favors outcome. Herein, we investigated anti-tumorigenic potential polyphenols from five different brown-algae in human PC cells (MiaPaCa-2, Panc-1, BXPC-3 Panc-3.27)....
ASXL1 mutation frequently occurs in all forms of myeloid malignancies and is associated with aggressive disease poor prognosis. recruits Polycomb repressive complex 2 (PRC2) to specific gene loci repress transcription through trimethylation histone H3 on lysine 27 (H3K27me3). alterations reduce H3K27me3 levels, which results leukemogenic expression the development malignancies. Standard therapies for have limited efficacy when mutated present. We discovered upregulation demethylase 6B...
Abstract A5 Seaweeds are potential renewable resources of the marine environment. They low in fats but contain vitamins and bioactive compounds like terpenoids sulphated polysaccharides. Sulphated polysaccharides from brown algae found to exhibit diverse biological activities anticoagulant, antihyperlipidemic, antiviral, antioxidant, antitumor, antimetastatic antiangiogenic activities. In this study, antiproliferative, antiinvasive properties seaweed, Sargassum wightii (Greville) against...
Abstract A4 Seaweeds are considered to be a rich source of biologically active substances like antioxidants, anti-viral, anti-inflammatory and anticoagulant agents. There some evidences that seaweeds contain compounds with relatively high antioxidant antiproliferative activity. low in fats but vitamins bioactive compounds, terpenoids sulfated polysaccharides. Sulphated polysaccharides from brown algae found exhibit diverse biological activities anticoagulant, antihyperlipidemic, antiviral,...
Kidneys are one of the main dose-limiting organs in radiotherapeutic procedures lower abdomen. Likewise, threat exposure radiosensitive such as kidneys warfare or radiation accidents among military personal due to terrorist activities general public is increasing concern. These events warrant need for appropriate animal models study acute and chronic effects low- high-dose rate exposures. In this study, first time, we validated Tsc2+/- mouse model whether accelerates carcinogenesis kidneys....
Abstract Poor prognosis of pancreatic cancer (PC) has been attributed to its resistance apoptosis and propensity for early systemic dissemination. Existing therapeutic strategies are often circumvented by the molecular crosstalk between cell signaling pathways. The fact that p53 is mutated in more than 50% PC tissues NFκB constitutively activated therapy resistant residual accounts evaded death In this study, we examined benefit fucoidan from a marine brown alga, Turbinaria conoides against...
Abstract Pancreatic cancer is one of the most deadly cancers with a five year survival rate less than six percent. The poor prognosis can be attributed to fact that more three fourth patients have metastasis at time diagnosis. In view increasing evidence sulfated polysaccharides attenuate tumor invasion, we attempted evaluate anti-metastatic potential polysaccharide fractions from marine brown alga, Turbinaria conoides in pancreatic cancer. Exposure human adenocarcinoma cells (MiaPaCa-2,...
Abstract Pancreatic cancer remains the fourth leading cause of death with an unacceptable survival that has remained relatively unchanged over past 25 years. The presence occult or clinical metastases at time diagnosis together lack effective chemotherapies pose a dire need for designing new and targeted therapeutic deliverables favors outcome. Herein, we investigated anti-tumorigenic potential polyphenols from five different brown-algae in human pancreatic cells (MiaPaCa-2, Panc-1, BXPC-3...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI