A5101908725- Cancer-related Molecular Pathways
- Radioactive contamination and transfer
- Air Quality and Health Impacts
- Immunotoxicology and immune responses
- Chemical Safety and Risk Management
- Glutathione Transferases and Polymorphisms
- Bacillus and Francisella bacterial research
- Protein Degradation and Inhibitors
- Animal testing and alternatives
- Carcinogens and Genotoxicity Assessment
- Genomics, phytochemicals, and oxidative stress
- Free Radicals and Antioxidants
- Climate Change and Health Impacts
- Radioactivity and Radon Measurements
- Ubiquitin and proteasome pathways
Jamia Hamdard
2012-2022
Hamdard University
2014
E3 ubiquitin ligases have been implicated in the ubiquitination and proteasome-mediated degradation of several key regulators cell cycle. Owing to their pleotropic behavior, are tightly regulated both at transcriptional post-translational levels. The ligase TRUSS (tumor necrosis factor receptor-associated ubiquitous scaffolding signaling protein) which negatively regulates c-Myc, found down-regulated most human cancer lines. However, mechanism regulation intracellular levels remains elusive....
Skin contamination is one of the most likely risks after accidental or occupational radiological accidents. Using scintigraphy, we assessed a topical lotion for its decontamination efficacy (DE) exposure with short-lived medical radioisotopes technetium Tc 99m (99mTc) and thallium 201Tl (201Tl).Using 99mTc (300 ± 5 μCi/100 μl) (100 μl), thoracoabdominal region (shaved skin) Sprague Dawley rats human tissue equivalent were contaminated then decontaminated using cotton swabs soaked in...
We examined the clastogenic and cell-transforming potential of ultrafine particulate matter fraction PM0.056 urban ambient aerosol using mammalian cells. PM1.0, PM0.56 fractions were sampled from roadside atmosphere an area cascade impactor MOUDI-NR-110. The to induce cytotoxicity, DNA damage micronuclei formation was at test concentrations 3, 6, 12.5, 25, 50 100 μg/ml 3-4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide...
Abstract Lung cancer, one of the most common cancer is a cause concern associated with cancer‐related mortality. Benzo[a]pyrene [B(a)P], potent carcinogen as well an environmental contaminant reported to be found in cigarette smoke among various sources. The present study focuses on chemopreventive potential Diosmin against B[a]P‐induced lung carcinogenesis and its possible mechanism male Swiss Albino mice (SAM). SAM were treated orally (200 mg/kg b.w.) for 16 weeks and/or B[a]P (50 b.w)...