A5090973854- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Cytomegalovirus and herpesvirus research
- Lipoproteins and Cardiovascular Health
- Parasitic infections in humans and animals
- Bartonella species infections research
- Antimicrobial Resistance in Staphylococcus
- Peptidase Inhibition and Analysis
- Biomarkers in Disease Mechanisms
- Herpesvirus Infections and Treatments
- Hematological disorders and diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Surgical Treatments
- Nephrotoxicity and Medicinal Plants
- SARS-CoV-2 and COVID-19 Research
- Nanoparticles: synthesis and applications
- Adipose Tissue and Metabolism
- Synthesis and biological activity
- Protease and Inhibitor Mechanisms
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced Nanomaterials in Catalysis
- COVID-19 epidemiological studies
- Bariatric Surgery and Outcomes
University of Medicine and Pharmacy of Craiova
2016-2024
CTX-M betalactamases have shown a rapid spread in the recent years among Enterobacteriaceae and become most prevalent Extended Spectrum Beta-Lactamases (ESBLs) many parts of world. The introduction dissemination antibiotic-resistant genes limits options for treatment, increases mortality morbidity patients, leads to longer hospitalization expensive costs. We aimed identify beta-lactamases circulating encoded by blaCTX-M-15, blaSHV-1 blaTEM-1 Escherichia coli (E. coli) Klebsiella pneumoniae...
The most severe infections are invasive infections, due to the fact that germs can accumulate in multiple sites and produce a body-wide infection known as sepsis. Septic shock has highest mortality rate among non-traumatic medical conditions. In this study, we aimed evaluate incidence prevalence of hospital environment. Another second objective was establish aetiology our antibiotic resistance profile involved, which both important for determining therapeutic approach treatment these...
Introduction: Bloodstream infections are the most severe that cause highest mortality rate, especially in patients admitted to intensive care unit (ICU). In this study, we aimed analyze distribution, resistance patterns and prevalence of MDR (multidrug-resistant) pathogens isolated blood samples collected from with invasive hospitalized ICU. Methods: A retrospective study bacterial was performed on 490 ICU between 2017 2020. The were analyzed using Vitek 2 Compact system. Results: total, 617...
Study Motivation: After assessing electronic databases of medical scientific literature, we have observed that the interrelation between urinary tract infections (UTIs) and chronic kidney disease (CKD) is poorly studied, especially when UTIs are caused by Klebsiella pneumoniae (K. pneumoniae).K. was isolated in 14 urine samples from patients with CKD addmited Nephrology Department County Emergency Clinical Hospital Craiova. The strains were statistically analyzed correlation different...
Background: Pregnancy-related infections with the human herpes simplex virus (HSV) strains HSV-1 and HSV-2 are particularly noteworthy. There numerous reported examples of intrapartum transmission infection, notwithstanding extreme rarity intrauterine transfer from mother to fetus. The purpose this study was evaluate seroprevalence antibodies in pregnant women western region Romania. Methods: Pregnant who presented for routine pregnancy monitoring at Romania’s County Clinical Emergency...
Cardiovascular risk means the degree of for atherosclerotic cardiovascular pathology, predictable by quantifying factors (RF) existing in each individual. Global cardio-metabolic is overall developing type 2 diabetes mellitus (T2DM) and/or CVD, including myocardial infarction (MI) and stroke, which due to a bundle factors. The based on concept continuous risk. importance / particular because controlling its components may affect atherogenesis clinical consequences: chronic ischemic heart...
Klebsiella infections are common in Intensive Care Unit (ICU) and surgical wards. In order to establish the prophylaxis protocols, we must know prevalence of antibiotic resistance profiles.This cross-sectional study included isolates from patients County Clinical Emergency Hospital, Craiova, Romania: 1254 ICU 1040 We used an automated method (Phoenix analyzer, Becton-Dickinson, USA) with antimicrobial testing according CLSI 2014. tested by disc diffusion ESBL carbapenemases production, using...
Identifying certain serum biomarkers associated with the degree of rheumatoid arthritis (RA) activity can provide us a more accurate view evolution, prognosis, and future quality life for these patients. Our aim was to analyze presence clinical use matrix metalloproteinase-13 (MMP-13), along vascular endothelial growth factor (VEGF) well-known cytokines such as tumor necrosis factor-alpha (TNF-α) interleukin 6 (IL-6) patients RA. We also wanted identify possible correlations between MMP-13...
We intended to investigate the presence and medical application of serum hypoxia-inducible factor-1 alpha (HIF-1α) along with already known systemic inflammatory markers new one's indices, proportion mean corpuscular volume lymphocytes (MCVL) cumulative index (IIC), for patients ulcerative colitis (UC). sought establish correlations that may be present between levels HIF-1α these as well their relationship disease activity extent UC, which can provide us a more precise understanding...
Olanzapine is one of the atypical antipsychotics widely used in treatment schizophrenia and has been associated with metabolic changes as adverse effects, including hyperglycemia, dyslipidemia, weight gain. In a batch adult female Wistar rats, we studied prolonged-release intramuscular olanzapine pamoate induced quantitative visceral subcutaneous adipose tissue. We also assessed effects combinations melatonin, metformin, melatonin plus administered by gastric gavage. A higher mean tissue per...
Chronic kidney disease (CKD) affects about 10-13% of the general population with a small proportion in terminal renal stage requiring replacement therapy or transplantation. CKD is new cause mortality US. CKD�s prevalence increases age. Diabetes mellitus responsible for 50% cases chronic being most common cause.
Azoles are the main antifungal agents currently used in systemic therapy and local mycoses. The class of azole derivatives has been studied using fingerprint descriptors based on electronegativity occupied molecular orbitals (OMO) unoccupied (UMO). Hansch equations that correlates partition coefficient with chemical structure allows us to identify nature atoms involved ligand (drug) - receptor interactions, as well those interactions. results indicate most reactive states, such states HOMO...
Breast cancer is the most common type of in women worldwide and second overall, making it a major international concern from both socio economical point view. World Health Organisation (WHO) estimated that over 508.000 died 2011 due to breast cancer. American Cancer Society�s (ACS) study conducted 2017 showed important numbers about burden Therefore, they number 252,710 new be diagnosed 2,470 men 2017- only America. On 1st January , there were 3.5million US with history The paper presents...
Idiopathic short stature (ISS) deficiency reflects a major public health issue. In Romania the incidence is 1/3000 - 6000 births, with an increased prevalence in boys. ISS condition where height of subject more than -2.5 DS below population for which it included, mean age and sex, but without any nutritional, systemic or chromosomal abnormalities. Significant children that weight normal at birth growth hormone levels are normal. This study shows evolution to values specific biological age,...