A5025777976- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- Biochemical effects in animals
- Cannabis and Cannabinoid Research
- Antioxidant Activity and Oxidative Stress
- Free Radicals and Antioxidants
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Organ Transplantation Techniques and Outcomes
- Diabetes Treatment and Management
- Food Quality and Safety Studies
- Coffee research and impacts
- Essential Oils and Antimicrobial Activity
- Redox biology and oxidative stress
- Pesticide Residue Analysis and Safety
- Diet and metabolism studies
- Antibiotics Pharmacokinetics and Efficacy
- Metabolism, Diabetes, and Cancer
- Exercise and Physiological Responses
- Neurological Disease Mechanisms and Treatments
- Pharmacology and Obesity Treatment
Université de Strasbourg
2014-2020
Diabète et thérapie cellulaire
2016
As a result of the increased consumption sugar-rich and fatty-products, increase in preference for such products, metabolic disorders are becoming more common at younger age. Fructose is particularly used prepared foods carbonated beverages. We investigated impact regular fructose, combination or not with fatty food, on onset syndrome type 2 diabetes (T2D). evaluated metabolic, oxidative, functional effects liver blood vessels, both related to complications. High-fat diet (HFD),...
Metabolic syndrome is associated with an increased risk of cardiovascular and hepatic complications. Oxidative stress in metabolic tissues has emerged as a universal feature its co-morbidities. We aimed to develop rapidly easily induced model rats evaluate impact on plasma tissue oxidative stress. was using high-fat diet (HFD), these were compared fed normal (ND) for 2 months. control determined by measuring body weight, blood glucose, triglycerides, lipid peroxidation protein carbonylation...
Since their isolation until implantation, pancreatic islets suffer a major stress leading to the activation of inflammatory reactions. The maintenance controlled inflammation is essential preserve survival and function graft. Identification targeting pathway(s) implicated in post-transplant detrimental events, mandatory improve islet transplantation success. We sought characterize expression pro-inflammatory pro-oxidant mediators during culture with focus on Heme oxygenase (HO-1) Toll-like...
Background and Purpose Liraglutide improves the metabolic control of diabetic animals after islet transplantation. However, mechanisms underlying this effect remain unknown. The objective study was to evaluate anti‐inflammatory anti‐oxidative properties liraglutide on rat pancreatic islets in vitro vivo . Experimental Approach In , were incubated with 10 μmol·L −1 for 12 24 h. Islet viability functionality assessed. evaluated by measuring CCL2, IL‐6 IL‐10 secretion macrophage chemotaxis....
Hyperglycemia occurs during diabetes and insulin resistance. It causes oxidative stress by increasing reactive oxygen species (ROS) levels, leading to cellular damage. Polyphenols play a central role in defense against stress. In our study, we investigated the antioxidant properties of simmondsin, pure molecule present jojoba seeds, aqueous extract seeds on fructose-induced RINm5f beta cells. The exposure cells fructose triggered loss cell viability (-48%, p < 0.001) disruption secretion (p...
Long-term insulin delivery can reduce blood glucose variability in diabetic patients. In this study, its impact on oxidative stress status, inflammation, and liver injury was investigated. Diabetes induced Wistar rats with a single dose of streptozotocin (100 mg/kg). Untreated administered Insuplant® (2 UI/200 g/day) through subcutaneous osmotic pump for one or four weeks were compared non-diabetic controls. Body weight, fructosamine level, total cholesterol, Insulin Growth Factor-1 (IGF-1)...
Intraperitoneal insulin allows physiological portal administration and first-pass hepatic extraction, but the impact on liver metabolism inflammation is unknown. Our objective was to compare impact, metabolic control function, of same dose administered either intraperitoneally or subcutaneously during continuous infusion in diabetic rats. Wistar rats were randomly divided into 4 groups: (C), untreated (streptozotocin, 100 mg/kg) treated by continual subcutaneous Insuplant® (CSII)...
Oxidative stress (OS) plays an important role in type 2 diabetes (T2D) pathogenesis and its complications. New therapies target natural antioxidants as alternative and/or supplemental strategy to prevent control them. Our previous chemical biological studies highlighted the antioxidant activities of cherries, among other fruits vegetables, thus we aimed determine vivo effects 2-month long cherry consumption using a high-fat/high-fructose (HFHF) model diabetic-rats (Lozano et al. Nutr Metab...
Exogenous insulin is the only treatment available for type 1 diabetic patients and mostly administered by subcutaneous (SC) injection in a basal bolus scheme using pens (injection) or pumps (preimplanted SC catheter). Some divergence exists between these two modes of administration, since provide better glycaemic control compared to injections humans. The aim this study was compare impacts administration (single long-acting pump delivery rapid-acting insulin) at same dosage (4 IU/200 g/day)...
Aims . Oxidative stress (OS) plays a major role in type 2 diabetes and its vascular hepatic complications, novel therapeutic approaches include natural antioxidants. Our previous chemical biological studies demonstrated the antioxidant activities of red cabbage (RC), here, we aimed to determine vivo effects 2‐month long RC consumption using high‐fat/high‐fructose model diabetic rats. Results This vegetable, associated with lifestyle measurement, was shown decrease OS increase endothelial NO...
The in vitro methods currently used to screen bioactive compounds focus on the use of a single model oxidative stress. However, this simplistic view may lead conflicting results. aim study was evaluate antioxidant properties two natural extracts (a mix red wine polyphenols (RWPs) and epigallocatechin gallate (EGCG)) with three models stress induced hydrogen peroxide (H2O2), mixture hypoxanthine xanthine oxidase (HX/XO), or streptozotocin (STZ) RINm5F beta cells. We employed multiple...
Evaluation of the action various traditional plants to treat metabolic syndrome are strongly studied. In our study, we investigated effect Tunisian jojoba seed on a induced in rat by High Fat diet and Fructose (HFHF) its renal hepatic complications.The rats were fed with HFHF or Normal Diet (ND) for period 8 weeks. After that, switch from ND Jojoba (NDJ),(jojoba approach) (HFHFJ) (nutraceutical has been done. Metabolic disorder was evaluated measuring fasting body weight, glycemia C-peptide...
The extraction of bioactive compounds from medicinal plants requires methods which are as diverse the chemical nature themselves. In this study, a 96-well microplate was used where solvent mixtures spanning wide ranges selectivity and polarity were tested with objective extracting broad range plant material. Microplate wells filled material solvents their added. obtained extracts assessed in terms total antioxidant activity, oxygen radical absorbance capacity effects on cell viability. An...
Objectives: Oxidative stress plays a major role in the pathophysiology of type 2 diabetes and today new therapeutics target natural antioxidants as an alternative/additional strategy. Our studies, combining chemistry biology, aimed to compare anti-oxidant properties fruits vegetables (F&V) validate vivo effect selected products on complications. Methodology: HPLC-ABTS.+ assay was realized 27 F&V extracts (polar, nonpolar, oil). In vivo, induced by months high-fat-high-fructose (HFHF) dietary...