A5034015135- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Forensic Toxicology and Drug Analysis
- Chemical synthesis and alkaloids
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Cannabis and Cannabinoid Research
- Biochemical Analysis and Sensing Techniques
- Neurobiology and Insect Physiology Research
- Drug Transport and Resistance Mechanisms
- Alcohol Consumption and Health Effects
- Advanced NMR Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Cellular transport and secretion
- DNA and Nucleic Acid Chemistry
- Poisoning and overdose treatments
- Effects and risks of endocrine disrupting chemicals
- HER2/EGFR in Cancer Research
- Alkaloids: synthesis and pharmacology
- Diabetes Treatment and Management
- Drug-Induced Hepatotoxicity and Protection
- Click Chemistry and Applications
- Treatment of Major Depression
- Nicotinic Acetylcholine Receptors Study
- Science, Research, and Medicine
University Hospital of Basel
2015-2025
University of Basel
2015-2025
Medical University of Vienna
2019-2024
Institute of Pharmacology
2021-2022
TU Wien
2020-2022
Swiss Centre for Applied Human Toxicology
2017
Utrecht University
2013-2014
Abstract Mescaline, lysergic acid diethylamide (LSD), and psilocybin are classic serotonergic psychedelics. A valid, direct comparison of the effects these substances is lacking. The main goal present study was to investigate potential pharmacological, physiological phenomenological differences at psychoactive-equivalent doses mescaline, LSD, psilocybin. used a randomized, double-blind, placebo-controlled, cross-over design compare acute subjective effects, autonomic pharmacokinetics...
N,N-dimethyltryptamine (DMT) is distinct among classic serotonergic psychedelics because of its short-lasting effects when administered intravenously. Despite growing interest in the experimental and therapeutic use intravenous DMT, data are lacking on clinical pharmacology. We conducted a double-blind, randomized, placebo-controlled crossover trial 27 healthy participants to test different DMT administration regimens: placebo, low infusion (0.6 mg/min), high (1 bolus + (15 mg 0.6 (25 1...
Abstract Organic cation transporters (OCTs) facilitate the translocation of catecholamines, drugs and xenobiotics across plasma membrane in various tissues throughout human body. OCT3 plays a key role low-affinity, high-capacity uptake monoamines most including heart, brain liver. Its deregulation diseases. Despite its importance, structural basis function inhibition has remained enigmatic. Here we describe cryo-EM structure at 3.2 Å resolution. Structures bound to two inhibitors,...
Pharmacological profiles of new psychoactive substances can be established rapidly in vitro and provide information on potential effects humans. The present study investigated whether specific monoamine transporter receptor interactions predict effective doses humans.We correlated previously assessed data stimulants psychedelics with human that are reported the Internet books.For stimulants, dopamine norepinephrine inhibition potency was positively doses, whereas serotonin inversely doses....
New psychoactive stimulants and psychedelics continue to play an important role on the illicit new substance (NPS) market. Designer both affect monoaminergic systems, although by different mechanisms. Stimulant NPS primarily interact with monoamine transporters, either as inhibitors or substrates. Psychedelic most potently serotonergic receptors mediate their mind-altering effects mainly through agonism at serotonin 5-hydroxytryptamine-2A (5-HT2A) receptors. Rarely, designer are associated...
Following its evoked release, dopamine (DA) signaling is rapidly terminated by presynaptic reuptake, mediated the cocaine-sensitive DA transporter (DAT). DAT surface availability dynamically regulated endocytic trafficking, and direct protein kinase C (PKC) activation acutely diminishes expression accelerating internalization. Previous cell line studies demonstrated that PKC-stimulated endocytosis requires both Ack1 inactivation, which releases a DAT-specific brake, neuronal GTPase, Rit2,...
Psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), are being investigated for the treatment of depressive anxiety disorders, which concomitant with selective serotonin reuptake inhibitors (SSRIs) is prevalent. The present study acute response to single doses LSD (100 μg) after daily administration paroxetine (10 mg 7 days, followed by 20 35 days) or placebo (42 using a randomized, double‐blind, cross‐over design in 23 healthy participants. Paroxetine did not alter...
Importance Microdosing psychedelics, including lysergic acid diethylamide (LSD), has gained attention for its potential benefits in several psychiatric disorders, attention-deficit/hyperactivity disorder (ADHD). However, LSD’s efficacy reducing ADHD symptoms remains unknown. Objective To determine the safety and of repeated low doses LSD compared with placebo. Design, Setting, Participants This was a 6-week, multicenter, double-blind, placebo-controlled, parallel-group phase 2A randomized...
Halogenated derivatives of amphetamine-type stimulants are appearing on the drug market, often with altered pharmacological profile and sometimes different legal status compared to non-halogenated substances. The aim present study was investigate hepatocellular toxicity para-halogenated amphetamines cathinones. potential amphetamine, 4-fluoroamphetamine, 4-chloroamphetamine, methcathinone, 4-fluoromethcathinone, 4-chloromethcathinone inhibit monoamine transporters for norepinephrine,...
The indole alkaloid N,N-dimethyltryptamine (DMT) induces psychedelic effects in humans. In addition to ceremonial and recreational use, DMT is subject clinical investigations. Sensitive bioanalytical methods are required assess the pharmacokinetics of its metabolites human plasma. Here, a high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantification major indole-3-acetic acid (IAA) DMT-N-oxide (DMT-NO) was developed validated. As IAA an endogenous...
The plasmalemmal norepinephrine transporter (NET) regulates cardiovascular sympathetic activity by clearing extracellular in the synaptic cleft. Here, we investigate subunit stoichiometry and function of NET using single-molecule fluorescence microscopy flux assays. In particular, show effect phosphatidylinositol 4,5-bisphosphate (PIP
Abstract Racemic 3,4-methylenedioxymethamphetamine (MDMA) acutely increases mood, feelings of empathy, trust, and closeness to others is investigated assist psychotherapy. Preclinical research indicates that S -MDMA releases monoamines oxytocin more potently than R -MDMA, whereas stimulates serotonin 5-hydroxytryptamine-2A receptors. may have stimulant properties, be psychedelic-like. However, acute effects - not been examined in a controlled human study. We used double-blind, randomized,...
Background: Amphetamine analogs with a 3,4-methylenedioxy ring-substitution are among the most popular illicit drugs of abuse, exerting stimulant and entactogenic effects. Enzymatic N-demethylation or opening ring via O-demethylenation gives rise to metabolites that may be pharmacologically active. Indeed, previous studies in rats show specific 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxymethcathinone (methylone) 3,4-methylenedioxypyrovalerone (MDPV) can interact...
3,4,5-Trimethoxyphenethylamine (mescaline) is a psychedelic alkaloid found in peyote cactus. Related 4-alkoxy-3,5-dimethoxy-substituted phenethylamines (scalines) and amphetamines (3C-scalines) are reported to induce similarly potent effects therefore potential novel therapeutics for psychedelic-assisted therapy. Herein, several pharmacologically uninvestigated scalines 3C-scalines were examined at key monoamine targets vitro. Binding affinity human serotonergic 5-HT1A, 5-HT2A, 5-HT2C,...
ABSTRACT Regorafenib has recently been approved for the treatment of colorectal cancer. A bioanalytical liquid chromatography–tandem mass spectrometric assay this multikinase inhibitor was developed and validated in plasma. The concentration range 25–25,000 ng/mL. Protein precipitation with acetonitrile used as sample pre‐treatment sorafenib internal standard. extract diluted methanol (25%, v/v) then injected onto sub‐2 µm particle, bridged ethylsilicia hybrid trifunctional bonded C 18...