A5063838454- Psychedelics and Drug Studies
- Calcium Carbonate Crystallization and Inhibition
- Forensic Toxicology and Drug Analysis
- Chemical synthesis and alkaloids
- Crystallization and Solubility Studies
- Neurotransmitter Receptor Influence on Behavior
- Dental Erosion and Treatment
- Dental materials and restorations
- Fluoride Effects and Removal
- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Minerals Flotation and Separation Techniques
- Electrostatics and Colloid Interactions
- Biochemical Analysis and Sensing Techniques
- Pickering emulsions and particle stabilization
- Cultural Heritage Materials Analysis
- Cannabis and Cannabinoid Research
- Adsorption and biosorption for pollutant removal
- Proteins in Food Systems
- Laser Applications in Dentistry and Medicine
- Solid State Laser Technologies
- Clay minerals and soil interactions
- Material Dynamics and Properties
- Drug Solubulity and Delivery Systems
- Geophysical and Geoelectrical Methods
University Hospital of Basel
2021-2025
University of Basel
2021-2025
Inserm
1987-1993
Centre National de la Recherche Scientifique
1989-1993
Institut Charles Sadron
1993
Hôpital Civil, Strasbourg
1989
Université de Strasbourg
1987
Abstract Mescaline, lysergic acid diethylamide (LSD), and psilocybin are classic serotonergic psychedelics. A valid, direct comparison of the effects these substances is lacking. The main goal present study was to investigate potential pharmacological, physiological phenomenological differences at psychoactive-equivalent doses mescaline, LSD, psilocybin. used a randomized, double-blind, placebo-controlled, cross-over design compare acute subjective effects, autonomic pharmacokinetics...
In vivo , psilocybin is rapidly dephosphorylated to psilocin which induces psychedelic effects by interacting with the 5-HT 2A receptor. Psilocin primarily undergoes glucuronidation or conversion 4-hydroxyindole-3-acetic acid (4-HIAA). Herein, we investigated psilocybin’s metabolic pathways in vitro and conducting a thorough analysis of enzymes involved. Metabolism studies were performed using human liver microsomes (HLM), cytochrome P450 (CYP) enzymes, monoamine oxidase (MAO),...
Psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), are being investigated for the treatment of depressive anxiety disorders, which concomitant with selective serotonin reuptake inhibitors (SSRIs) is prevalent. The present study acute response to single doses LSD (100 μg) after daily administration paroxetine (10 mg 7 days, followed by 20 35 days) or placebo (42 using a randomized, double‐blind, cross‐over design in 23 healthy participants. Paroxetine did not alter...
Pyrovalerone cathinones are potent psychoactive substances that possess a pyrrolidine moiety. Pyrovalerone-type novel (NPS) continuously detected but their pharmacology and toxicology largely unknown. We assessed several pyrovalerone related cathinone derivatives at the human norepinephrine (NET), dopamine (DAT), serotonin (SERT) uptake transporters using HEK293 cells overexpressing each respective transporter. examined transporter-mediated monoamine efflux in preloaded cells. The receptor...
Mescaline is a psychedelic phenethylamine found in different species of cacti. Currently, mescaline's acute subjective effects and pharmacokinetics are investigated several modern clinical studies. Therefore, we developed bioanalytical method for the rapid quantification mescaline its metabolites human plasma. 3,4,5-trimethoxyphenylacetic acid (TMPAA), N-acetyl (NAM), 3,5-dimethoxy-4-hydroxyphenethylamine (4-desmethyl mescaline) were simultaneously analyzed by ultra-high performance liquid...
Diamorphine, commonly known as heroin, is a semi-synthetic opioid analgesic. In the context of heroin-assisted treatment for opioid-dependent patients, diamorphine mostly administered intravenously. However, recent attention has shifted towards intranasal administration better-tolerated alternative to intravenous route. Here, we developed and validated rapid bioanalytical method simultaneous quantification its major metabolites 6-monoacetylmorphine, morphine, morphine-3-glucuronide,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModel for the dissolution of calcium hydroxyapatite powderS. Mafe, J. A. Manzanares, H. Reiss, M. Thomann, and P. GramainCite this: Phys. Chem. 1992, 96, 2, 861–866Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/j100181a062https://doi.org/10.1021/j100181a062research-articleACS PublicationsRequest reuse permissionsArticle...
3,4-Methylenedioxymethamphetamine (MDMA) is an entactogen with therapeutic potential. The two enantiomers of MDMA differ regarding their pharmacokinetics and pharmacodynamics but the chiral pharmacology needs further study in clinical trials. Here, achiral enantioselective high performance liquid chromatography-tandem mass spectrometry method for quantification its psychoactive phase I metabolite 3,4-methylenedioxyamphetamine (MDA) human plasma were developed validated. analytes detected by...
The aim of this study was to determine the crystalline structure and chemical alterations synthetic hydroxyapatite after irradiation with either CO2, Nd:YAG or CO2-Nd:YAG combination lasers at high energy densities 500-3,230 J·cm2. Further, dissolution kinetics lased material were analysed compared those unlased apatite. Electron microscopy showed that consisted two kinds crystals. From micrographs their diameters varied from 600 1,200 Å 3,000 6,000 A, respectively. larger crystals...