A5065353487- Food Allergy and Anaphylaxis Research
- Monoclonal and Polyclonal Antibodies Research
- Mast cells and histamine
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Fluoride Effects and Removal
- Radioactive element chemistry and processing
- Allergic Rhinitis and Sensitization
- Skin Protection and Aging
- Transgenic Plants and Applications
- Ion-surface interactions and analysis
- Phytochemicals and Antioxidant Activities
- Advanced Glycation End Products research
- Neurogenetic and Muscular Disorders Research
- Urticaria and Related Conditions
- CO2 Sequestration and Geologic Interactions
- Chemical and Physical Properties in Aqueous Solutions
- Advanced X-ray Imaging Techniques
- Electron and X-Ray Spectroscopy Techniques
- Polyamine Metabolism and Applications
- melanin and skin pigmentation
- Spinal Cord Injury Research
- Natural Antidiabetic Agents Studies
- Exercise and Physiological Responses
- Mercury impact and mitigation studies
University of Bern
2016-2021
University Hospital of Bern
2016-2021
PCAS (France)
2008-2011
ETH Zurich
2008-2010
University of Zurich
2010
Universitätsklinik Balgrist
2010
Swiss Federal Laboratories for Materials Science and Technology
2004-2007
Inserm
1990-1995
Centre National de la Recherche Scientifique
1990-1994
Institut Charles Sadron
1994
Abstract Targeting of immunoglobulin E (IgE) represents an interesting approach for the treatment allergic disorders. A high-affinity monoclonal anti-IgE antibody, ligelizumab, has recently been developed to overcome some limitations associated with clinical use therapeutic omalizumab. Here, we determine molecular binding profile and functional modes-of-action ligelizumab. We solve crystal structure ligelizumab bound IgE, report epitope differences between omalizumab that contribute their...
Abstract Background Binding of allergen‐specific IgE to its high‐affinity receptor Fcε RI on basophils and mast cells is a central event in the development allergies. Exposure these allergens induces release soluble mediators causing allergic symptoms. The inhibitory low‐affinity IgG Fc‐receptor Fcγ RIIB co‐expressed effector has been implicated negative regulation immediate hypersensitivity responses. In order harvest function this receptor, we aimed select specific binders against generate...
Abstract Objective Spinal cord injury (SCI) leads to permanent motor and sensory deficits due the damage of ascending descending fiber tracts. In addition, malfunctions such as neuropathic pain or muscle spasms develop in many patients, possibly caused by injury‐induced plastic changes neuronal circuits above below lesion. New treatment strategies for spinal aim at enhancing plasticity neurite growth, example, blocking key growth inhibitor Nogo‐A its downstream effectors. It is therefore...
Synopsis Polyphenols in general are compounds that known to promote health and have a preventive effect against various chronic diseases. The influence of cocoa polyphenols on skin, however, has scarcely been studied from histological point view. aim this study is assess the several indicators skin elasticity tonus, namely, glycosaminoglycans collagen I, III IV. This was carried out by using model ex vivo human explants maintained survival, which polyphenol extract applied. After processing...
Due to the development of integrated low-keV back-scattered electron detectors, it has become possible in focussed ion beam nanotomography segment not only solid matter and porosity hardened cement paste, but also distinguish different phases within matter. This paper illustrates a method that combines two approaches for improving contrast between matrix paste. The first approach is based on application specially developed 3D diffusion filter. second modified data-acquisition procedure...
Synopsis Glycation is an ageing reaction of naturally occurring sugars with dermal proteins, whose clinical signs may appear in vivo around age 30, and increases steadily/regularly age. The suppleness the dermis affected by formation bridges between proteins (Maillard’s reaction). residues formed (Amadori products, Advanced End products) as well they alter, can be visualized specific immunostainings. Induced a few days on living skin explants methylglyoxal, glycation prevented application...
Abstract Objective Hair greying (i.e., canities) is a component of chronological ageing and occurs regardless gender or ethnicity. Canities directly linked to the loss melanin increase in oxidative stress hair follicle shaft. To promote pigmentation reduce process, an agonist α ‐melanocyte‐stimulating hormone ( ‐ MSH ), biomimetic peptide (palmitoyl tetrapeptide‐20; PTP 20) was developed. The aim this study describe effects designed on greying. Methods Effect 20 enzymatic activity catalase...
Abstract The level of mercury vapors in the oral cavity was determined by analyzing 242 samples intra‐oral air before and after removing, setting, polishing dental amalgam. analysis effected using atomic absorption spectrometry cold with detection limit 6 μg/m 3 . A score 1 to assigned each restoration adjust differences amalgam sizes. present study showed that vapor released during any procedure: mean levels were between 85 326 However, restorative procedures, no had been detected cavity....
Abstract Antibody drugs exert therapeutic effects via a range of mechanisms, including competitive inhibition, allosteric modulation, and immune effector mechanisms. Facilitated dissociation is an additional mechanism where antibody-mediated “disruption” stable high-affinity macromolecular complexes can potentially enhance efficacy. However, this not well understood or utilized therapeutically. Here, we investigate engineer the weak disruptive activity existing antibody, omalizumab, which...
Abstract Background To tackle the growing allergy epidemic, novel therapeutic approaches are urgently needed. One promising avenue is development of anti-allergen antibody therapies. This passive immunization approach stands out from traditional allergen immunotherapy by not exposing patients to but also potentially treating who less responsive or even unresponsive immunotherapies and providing immediate protection. Methods After a review historical recently published literature on topic...