Glycation, and the resulting buildup of advanced glycation end products (AGEs), is recognized as a key driver cumulative skin damage aging. Dunaliella salina halophile microalga adapted to intense solar radiation through production carotenoids. We present natural supercritical CO2 extract rich in colorless carotenoids phytoene phytofluene. The exhibited antiglycation anti-inflammatory activities ex vivo testing, showing strongly reduced formation N-ε-carboxy-methyl-lysine with exposure...

Sleep is one of the most important factors affecting overall health. During night, skin repairs damage caused by daily stresses. Melatonin plays a key role in this process. Toxins are removed, and cellular repair growth hormone production increased. Inter alia, also decreases signs intrinsic aging.

Skin volatile emissions offer a noninvasive insight into metabolic activity within the body as well skin microbiome and specific compounds have been shown to correlate with age, albeit only in few small studies. Building on this, here volatiles were collected analyzed healthy participant study (

Abstract Objective Hair greying (i.e., canities) is a component of chronological ageing and occurs regardless gender or ethnicity. Canities directly linked to the loss melanin increase in oxidative stress hair follicle shaft. To promote pigmentation reduce process, an agonist α ‐melanocyte‐stimulating hormone ( ‐ MSH ), biomimetic peptide (palmitoyl tetrapeptide‐20; PTP 20) was developed. The aim this study describe effects designed on greying. Methods Effect 20 enzymatic activity catalase...

It may be hypothesized that wound healing will benefit from polymer membranes coated with extracellular matrix macromolecules. Here we describe the behavior of dermal fibroblasts on polysulfone (PSU) membranes, and PSU covered chitosan (Ch), chondroitin sulfate (CS), or hyaluronan, using an additional intermediary ionic charge modification poly-(acrylonitrile-co-methallyl sulfonate) (AN69), which allows binding polysaccharidic Cell adhesion, proliferation, cell signaling, collagen gene...

Acne is a chronic inflammatory skin disease that affects the quality of life patients. Several treatments exist for acne, but their effectiveness tends to decrease over time due increasing resistance treatment and associated side effects. To circumvent these issues, new approach has emerged involves combating pathogen Cutibacterium acnes while maintaining homeostasis microbiome. Recently, it was shown use G2 lysine dendrigraft (G2 dendrimer) could specifically C. phylotype (IAI) involved in...

Background: Next-generation 5G communication technology involves increasing use of 3–100 GHz wireless bands in population centers. Though still non-ionizing, this implies higher radiation energy vs. existing bands. The range is also shorter, needing more numerous emitters, closer to the user—resulting electromagnetic exposure. With no universal consensus regarding exposure risks, there some concern among public and scientific community, following indications that can impact immune function,...

Extracellular regulated kinase (ERK) signalling is believed to play roles in various aspects of circadian clock mechanisms. In this study, we show rat that the nuclear versus cytoplasmic intracellular distribution phosphorylated forms ERK1/2 (P-ERK1/2) central clock, namely suprachiasmatic nucleus (SCN), proportionally constant across light/dark cycle while spatial and neurochemical phenotype cells expressing these activated are time-regulated according a daily rhythm light-regulated....

Human epidermal keratinocytes and dermal fibroblasts were co-cultured on polysulfone (PSU) membranes, previously coated or not with hyaluronan (HA), compared to monocultured fibroblasts. The purpose was define the interplay between both cell types how it is influenced. co-cultures reduced I III collagen levels, indicating that exerted an inhibition matrix synthesis by On other hand, amounts of keratins 17 10 increased, suggesting stimulate production keratinocytes. In contrast naked PSU HA...

Polysulfone (PSU) membranes, coated and uncoated hyaluronan (HA), were compared for their ability to allow dermal fibroblast express genes related extracellular matrix synthesis remodeling. Fibroblasts type I III collagens studied on both types of membranes; only collagen was synthesized control cultures in plastic Petri dishes, whereas also expressed PSU membranes. Expression metalloproteinase (MMP)1, MMP3, MMP2 enhanced HA-coated with a lower level HA-covered These membranes promote...

As an external appendage, hair is exposed to multiple stresses of different origins such as particles and gases in air, or heavy metals chemicals water. So far, little research has addressed the impact water pollution on hair. The present study describes a new ex vivo model that allowed us document adverse effects pollutants structure proteins, well protective potential active cosmetic ingredients derived from biomimetic exopolysaccharide (EPS). was evaluated Caucasian donor repeatedly...

Skin microbiota, and its diversity balance, play a key role in skin health beauty, influencing moisture, barrier function, radiance. A healthy microbiota limits the growth of detrimental species, protecting from pathologies. Prebiotics can support beneficial populations outcompeting ones. Dragon fruit (Hylocereus undatus) contains prebiotic polysaccharides effective on gut bacteria. Its extract was tested vitro, coculture model including representative double-blind, placebo-controlled...

ABSTRACT Changes in the expression of cornified envelope (CE) components are a hallmark numerous pathological skin conditions and aging, underlying importance this stratum corneum structure homeostasis epidermal barrier. We performed detailed characterisation LCE6A, member Late Cornified Envelope protein family. Immunohistochemical immunoblot experiments confirmed that LCE6A is expressed late during differentiation. Crosslinking assays recombinant either situ on human sections or vitro...

With a view to reducing the impact of Cutibacterium acnes (C. acnes) on acne vulgaris, it now appears interesting modify balance between acneic and non-acneic strains C. using moderate approach. In present study, we identified that G2 dendrigraft lysine dendrimer (G2 dendrimer) was able membrane fluidity biofilm formation strain (RT5), whereas appeared no or less active (RT6). Moreover, skin ex vivo data indicated is decrease inflammation (IL1α TLR-2) improve desquamation after colonization....

Psychological stress exerts its effects mainly through the release of corticotropin releasing hormone (CRH), which activates inflammatory pathways in skin (inter alia), resulting redness, extracellular matrix degradation, loss elasticity and firmness, appearance wrinkles—namely, accelerated aging. In order to propose a solution this neurogenic aging phenomenon, we report here on studies using myricitrin-rich extract Cistus incanus, Mediterranean shrub used traditional medicine for treatment...