A5102801273- Asthma and respiratory diseases
- S100 Proteins and Annexins
- IL-33, ST2, and ILC Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Allergic Rhinitis and Sensitization
- Botulinum Toxin and Related Neurological Disorders
- Peptidase Inhibition and Analysis
- Neonatal Respiratory Health Research
- Occupational and environmental lung diseases
- Histone Deacetylase Inhibitors Research
- Neuroscience and Neural Engineering
- Immune Cell Function and Interaction
- History of Science and Natural History
- Urban and sociocultural dynamics
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Human Health and Disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Brazilian cultural history and politics
- Diverse Historical and Scientific Studies
- T-cell and B-cell Immunology
- Mesenchymal stem cell research
- Stroke Rehabilitation and Recovery
Fundação Oswaldo Cruz
2013-2022
Northwestern University
2012
Williams & Associates
2012
Endogenous glucocorticoids are pro-resolving mediators, an example of which is the endogenous glucocorticoid-regulated protein annexin A1 (ANXA1). Because silicosis occupational lung disease characterized by unabated inflammation and fibrosis, in this study we tested therapeutic properties N-terminal ANXA1-derived peptide 1-(2-26) (Ac2-26) on experimental silicosis.Swiss-Webster mice were administered silica particles intranasally subsequently treated with intranasal Ac2-26 (200 μg per...
Evidence suggests that nebulized lidocaine is beneficial in asthma therapy, but to what extent and the mechanisms underlying this effect remain poorly understood. The aim of study was assess impact treatment using a murine model allergic characterized by expression pivotal features disease: inflammation, mucus production, lung remodeling.A/J mice sensitized with ovalbumin were treated inhaled or vehicle immediately after intranasal challenges. Lung function, total differential leukocytes...
Summary Background Prophylactic administration of mesenchymal stromal cells ( MSC s) derived from adipose AD ‐ ) and bone marrow tissue BM in ovalbumin‐induced asthma hinders inflammation a Treg‐dependent manner. It is uncertain whether s act through Tregs when already established induced by clinically relevant allergen. Objective Evaluate the effect therapeutic on Treg house dust mite HDM )‐induced asthma. Methods were administered intratracheally to C57 BL /6 mice 1 day after last...
Abstract Instillation of silica into the lungs rodents results in pathological changes that strongly mimic human silicosis, an occupational lung disease marked by restrictive airway obstruction, inflammation, and fibrosis. Because IL-13 is a pivotal proinflammatory fibrogenic cytokine, we examined whether recombinant immunotoxin comprised mutated form Pseudomonas exotoxin (IL-13–PE) might affect features experimental silicosis. Mice received single intranasal instillation particles were...
Gold nanoparticles (AuNPs) can inhibit pivotal pathological changes in experimental asthma, but their effect on steroid-insensitive asthma is unclear. The current study assessed the effectiveness of nebulized AuNPs a murine model glucocorticoid (GC)-resistant asthma.A/J mice were sensitized and subjected to intranasal instillations ovalbumin (OVA) once week for nine weeks. Two weeks after starting allergen stimulations, Budesonide or AuNP nebulization 1 h before stimuli. Analyses carried out...
Asthma is an allergic inflammation driven by the Th2 immune response with release of cytokines such as IL-4 and IL-13, which contribute to airflow limitations airway hyperresponsiveness (AHR). The involvement oxidative stress in this process well-established, but specific role superoxide anion nitric oxide asthma are poorly understood. Thus, aim study was investigate mechanisms underlying anion/nitric production detoxification a murine model. BALB/c male mice were sensitised challenged...
Previous studies described that allergic diseases, including asthma, occur less often than expected in patients with type 1 diabetes. Here, we investigated the influence of diabetes on airway inflammation a model experimental asthma mice. Diabetes was induced by intravenous injection alloxan into 12 h-fasted A/J mice, followed subcutaneous sensitization ovalbumin (OVA) and aluminum hydroxide (Al(OH)3), days 5 19 after induction. Animals were intranasally challenged OVA (25 μg), from day 24...
Silicosis is a lethal fibro-granulomatous pulmonary disease highly prevalent in developing countries, for which no proper therapy available. Among small series of N-acylhydrazones, the safrole-derived compound LASSBio-897 (3-thienylidene-3, 4-methylenedioxybenzoylhydrazide) raised interest due to its ability bind adenosine A2A receptor. Here, we evaluated anti-inflammatory and anti-fibrotic potential LASSBio-897, exploring translation mouse model silicosis receptor as site action. Pulmonary...
Regulatory T cells (Tregs) are important in regulating responses to innocuous antigens, such as allergens, by controlling the Th2 response, a mechanism that appears be compromised atopic asthmatic individuals. Different isogenic mouse strains also have distinct immunological and susceptibility experimental protocols used develop lung allergic inflammation. In this work, we investigated differences frequency of Treg cell subtypes among A/J, BALB/c, C57BL/6, under normal conditions following...
Claude Bernard, best known for the concept of homeostasis in physiology, was also fascinated with anesthesia and its implications.As wonderfully described a special article editorial, Bernard's concepts that only living beings, including plants, could be anesthetized there are many anesthetic drugs but one state lay foundation our exploration mechanisms action.The image Bernard is courtesy
<b>Introduction:</b> Viral infections can trigger acute exacerbations of COPD (AECOPD) in a corticosteroid resistant way. Thus, we aim to develop model AECOPD by combining cigarette smoke and influenza virus infection for the identification molecular mechanisms more effective therapies. <b>Methods:</b> We exposed C57Bl/6 female mice ambient air or cigarette-smoke 12 days at day 7 infected them with 1000 pfu H1N1 intranasally. Groups: (AA), AA+1000 (AA1000), (CS), CS+1000 (CS1000). Mice lung...