A5037373612- HIV Research and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- HIV/AIDS Research and Interventions
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Immune Response and Inflammation
- vaccines and immunoinformatics approaches
- Sepsis Diagnosis and Treatment
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Reproductive System and Pregnancy
- Viral Infections and Vectors
- COVID-19 Impact on Reproduction
- HIV/AIDS oral health manifestations
- Biochemical and Molecular Research
- Virology and Viral Diseases
- Monoclonal and Polyclonal Antibodies Research
- Sperm and Testicular Function
- Immunotherapy and Immune Responses
- Adolescent Sexual and Reproductive Health
- Malaria Research and Control
Universidad de Antioquia
2014-2024
Inmunal (Spain)
2024
ORCID
2020
Center of Molecular Immunology (Cuba)
2008
University of Cincinnati Medical Center
2006-2008
Cincinnati Children's Hospital Medical Center
2006-2008
Karolinska University Hospital
2006
Karolinska Institutet
2006
Abstract Declines in immune function are well described the elderly and considered to contribute significantly disease burden this population. Regulatory T cells (Tregs), a CD4+ cell subset usually characterized by high CD25 expression, control intensity of responses both rodents humans. However, because expression does not define all Tregs, especially aged hosts, we Tregs FOXP3, transcription factor crucial for Treg differentiation function. The proportion FOXP3+CD4+ increased blood...
Objectives: To perform a complete immunological characterization of compensatory anti-inflammatory response syndrome in patients with sepsis and to explore the relationship between these changes clinical outcomes 28-day mortality secondary infections. Design: Prospective single-center study conducted April 2011 December 2012. Setting: ICUs from Hospital Universitario San Vicente Fundación at Medellin, Colombia. Patients: One hundred forty-eight severe sepsis. Interventions: None....
Statins have been shown to modulate the number and suppressive function of CD4 + FOXP3 T cells (Treg) in inflammatory conditions. However, it is not well established whether statin could also affect Treg absence inflammation. To address this question, eighteen normocholesterolemic male subjects were treated with lovastatin or atorvastatin daily for 45 days. The frequency phenotype circulating evaluated at days 0, 7, 30, 45. mRNA levels FOXP3, IDO, TGF- β , IL-10 measured cells. We found that...
Peripheral blood T-cells from untreated HIV-1-infected patients exhibit reduced immune responses, usually associated with a hyperactivated/exhausted phenotype compared to HAART treated patients. However, it is not clear whether ameliorates this altered of in the gastrointestinal-associated lymphoid tissue (GALT), main site for viral replication. Here, we peripheral and GALT two groups chronically patients: active replication, on suppressive HAART. We characterized T-cell by measuring PD-1,...
Despite the suppression of viral replication induced by highly active anti-retroviral therapy (HAART), an increased immune activation and inflammatory state persists in HIV-infected patients, contributing to lower treatment response reconstitution, development non-AIDS conditions. The chronic inflammation affect functionality differentiation CD8+ T-cells, particularly reducing their cytotoxic capacity, which is critical control HIV replication. Although previous studies have shown that HAART...
Chikungunya virus (CHIKV) is a zoonotic arthropod-borne that causes fever (CHIKF), self-limiting disease characterized by myalgia and acute or chronic arthralgia. CHIKF pathogenesis has an important immunological component since higher levels of pro-inflammatory factors, including cytokines chemokines, are detected in CHIKV-infected patients. In vitro studies, using monocytes macrophages have shown CHIKV infection promotes elevated production antiviral response factors. Vitamin D3 (VD3) been...
Although very inefficient, sexual transmission of HIV-1 is responsible for more than 80% infections worldwide. Yet, the presence HIV in spermatozoa has been a matter debate. The aim this study was to evaluate nucleic acids and distribution mannose receptors sperm cells, determine semen parameters cytokine levels ejaculates from HIV-positive patients. non-seminal cells purified revealed by light microscopy, flow cytometry RT-PCR. were evaluated nested PCR; distributions on surface determined...
Although dengue can progress to severe stages, the exact causes of this phenomenon are unknown; however, possibility monocyte participation is acknowledged. It has been suggested that subsets (classical, intermediate and non-classical) play differential roles in immunopathology. Therefore, we determined count obtained clinical information patients with dengue. We noted a significant decrease non-classical monocytes compared controls. With finding, focused on studying phenotype present study....
Introduction To evaluate the effect of late initiation HAART and poor immune reconstitution on frequency regulatory T-cells (Treg) in peripheral blood gut HIV-infected patients, we studied Colombian patients who had been suppressive for at least one year. They undetectable viremia but were either immunological responders (HIR); (CD4 counts >500 cells/µl) or non-immunological (NIR); T-cell count <300 cells/µl). Untreated uninfected controls from same region also evaluated. Methods Frequency...