A5034561165- Eating Disorders and Behaviors
- Obsessive-Compulsive Spectrum Disorders
- Advanced Causal Inference Techniques
- Obesity, Physical Activity, Diet
- Statistical Methods and Bayesian Inference
- Child Nutrition and Feeding Issues
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Statistical Methods and Inference
- Attention Deficit Hyperactivity Disorder
- Hidradenitis Suppurativa and Treatments
- Health disparities and outcomes
- Personality Traits and Psychology
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Sexuality, Behavior, and Technology
- Personality Disorders and Psychopathology
- Cognitive Abilities and Testing
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Stress Responses and Cortisol
- Psychological Treatments and Assessments
- Death Anxiety and Social Exclusion
McLean Hospital
2007-2025
Harvard University
2008-2025
Universidade de São Paulo
2024
University of Wisconsin–Madison
2007-2020
University of North Carolina at Chapel Hill
2015-2017
Imagerie et Cerveau
2011
Rhodes Trust
2007
University of Oxford
2003-2007
U.S. National Science Foundation
2003
Article AbstractObjective: To assess the co-occurrence offibromyalgia with psychiatric disorders in participants of afibromyalgia family study. Method: Patients (probands) fibromyalgia,control probands rheumatoid arthritis, and first-degreerelatives both groups completed a structured clinicalinterview tender point examination. The oddsratio (OR) (the odds lifetime comorbid DSM-IV disorder anindividual fibromyalgia divided by lifetimecomorbid an individual without fibromyalgia, adjustedfor...
Article Abstract Background: Prior studies suggest that certain psychiatric and medical disorders co-occur with binge eating disorder (BED). However, there has been no large, community-based study diagnoses made by clinician interviewers. We used data from type of to assess the co-occurrence various DSM-IV BED subthreshold BED. Method: From October 2002 July 2004, we interviewed 150 probands BED, without 888 their first-degree relatives (135 whom had 54 met specific partial criteria for...
To estimate the familiality and heritability of binge eating disorder (BED).We used a new ACE structural equation model to from case-control family study BED conducted in Boston area. The sample consisted 150 overweight/obese probands with lifetime by DSM-IV criteria, without BED, 888 their first-degree relatives. We compared our findings those (in absence compensatory behaviors) among 7,831 Norwegian twins.The prevalence differed sex age. In study, was found aggregate families, estimated as...
ABSTRACT Objective To investigate the sex‐ and age‐specific incidence of healthcare‐register‐recorded anorexia nervosa (AN) other eating disorders (OED) in a complete birth cohort, assess whether varies by diagnostic period (sub‐) cohort. Method We used actuarial method Poisson models to examine AN OED from 1987 2009 (when individuals were 8–30 years old) for cohort 2.3 million (48.7% female) born 1979 2001 Sweden, identified using Swedish registers. Results For both sexes, incidences...
A potential explanation for the finding that disadvantaged minority status is associated with a lower lifetime risk depression individuals from ethnic groups may be less likely to endorse survey questions about even when they have same level of depression. We examine this possibility using nonparametric item response theory approach assess differential functioning (DIF) in national psychiatric disorders, National Comorbidity Survey. Of 20 used symptoms, we found evidence DIF 3 comparing...
Greater levels of conscientiousness have been associated with lower negative affect.We focus on one mechanism through which may decrease affect: effective emotion regulation, as reflected by greater recovery from stimuli.In 273 adults who were 35 -85 years old, we collected self-report measures personality including and its self-control facet, followed average 2 later psychophysiological emotional reactivity recovery.Among middle-aged (35 -65 old), the predicted from, but not to, stimuli.The...
Likert attitude data consist of responses to favorable and unfavorable statements about an entity, where fall into ordered categories ranging from disagreement agreement. Social science marketing researchers frequently use this type measure attitudes toward entity such as a policy or product. We focus on American British their respective nations ("national pride"). introduce multidimensional unfolding model (MUM) describe the relationship between underlying them. Unlike most existing models,...
The demonstration that 2 disorders coaggregate in families is often the first step exploration of genetic factors common to disorders. Previous methods analyzing familial coaggregation have used either (1) a typical measure association (eg, odds ratio) between disorder an individual and another family members, or (2) linear structural equation model (SEM). method accommodates case-control sampling families, but may not assess causal effect interest because it based on underlying model. SEM...
Background Advanced paternal age at childbirth is associated with psychiatric disorders in offspring, including schizophrenia, bipolar disorder and autism. However, few studies have investigated age's relationship eating offspring. In a large, population-based cohort, we examined the association between offspring disorders, whether that remains after adjustment for potential confounders (e.g. parental education level) may be related to late/early selection into fatherhood incidence. Method...
Abstract Context Anorexia nervosa (AN) is prevalent in adolescent girls and associated with bone impairment driven by hormonal alterations nutritional deficiency. Objective To assess the impact of estrogen replacement without recombinant human insulin-like growth factor-1 (rhIGF-1) administration on outcomes. Design Double-blind, randomized, placebo-controlled 12-month longitudinal study. Participants Seventy-five young adult women AN age 14 to 22 years. Thirty-three participants completed...
Abstract Background Major depressive disorder (MDD) is often accompanied by changes in appetite and weight. Prior task-based functional magnetic resonance imaging (fMRI) findings suggest these MDD phenotypes are associated with altered reward interoceptive processing. Methods Using resting-state fMRI data, we compared the fractional amplitude of low-frequency fluctuations (fALFF) seed-based connectivity (SBC) among hyperphagic ( n = 77), hypophagic 66), euphagic 42) groups a healthy...
What is known about this subject in regard to women and their families? Hidradenitis suppurativa (HS) a chronic, inflammatory skin condition that predominantly affects people of color. Due its perceived association with increased disease severity, weight loss often recommended for these patients. Nationally, 11 20% college-aged develop eating disorders. Along more negative body image, lifestyle recommendation can lead an risk developing disorders patients HS. new from article as messages Our...
A number of studies have examined the association three major eating disorders—anorexia nervosa, bulimia and binge-eating disorder—with metabolic syndrome, or with individual components such as obesity, type 2 diabetes, hypertension, dyslipidemia. Present evidence suggests that anorexia nervosa confers no excess risk syndrome may be associated lower certain components, including obesity diabetes. Bulimia shows associations increased for in some studies, but not others. Binge-eating disorder,...
Abstract Background Epidemiological data offer conflicting views of the natural course binge-eating disorder (BED), with large retrospective studies suggesting a protracted and small prospective briefer duration. We thus examined changes in BED diagnostic status prospective, community-based study that was larger more representative respect to sex, age onset, body mass index (BMI) than prior multi-year studies. Methods Probands relatives current DSM-IV ( n = 156) from family (‘baseline’) were...
AbstractWe consider the application of multiple imputation to data containing not only partially missing categorical and continuous variables, but also 'semicontinuous' variables (variables that take on a single discrete value with positive probability are otherwise continuously distributed). As an model for sets this type, we introduce extension standard general location proposed by Olkin Tate; our extension, blocked model, provides robust strategy handling observed semicontinuous...
Abstract Investigators interested in whether a disease aggregates families often collect case‐control family data, which consist of status and covariate information for members selected via case or control probands. Here, we focus on the use data to investigate relative contributions additive genetic effects (A), shared environment (C), unique (E). We describe an ACE model binary data; this structural equation model, has been described previously, combines general‐family extension classic...
Comorbidity among childhood mental health symptoms is common in clinical and community samples should be accounted for when investigating etiology. We therefore aimed to uncover latent classes of middle a sample, determine the genetic environmental influences on those classes.The sample comprised representative cohorts twins. A questionnaire-based assessment was used class analyses. Data 3223 twins (1578 boys 1645 girls) with mean age 7.5 years were analyzed. The predominantly non-Hispanic...