About
Contact & Profiles
A5017904429
Research Areas
- Ubiquitin and proteasome pathways
- Virus-based gene therapy research
- interferon and immune responses
University of Birmingham
2019
Viruses have evolved to inhibit cellular DNA damage response pathways that possess antiviral activities and utilize proviral activities. Adenovirus has evolved, primarily, by engaging with the ubiquitin-proteasome system promoting degradation of key proteins. differentially regulates ATR signaling during infection. The adenovirus E1B-55K binding protein E1B-AP5 participates in activated infection, while 12 E4orf6 negates Chk1 activation proteasome-dependent activator TOPBP1. studies detailed...
10.1128/jvi.00402-19
article
EN
Journal of Virology
2019-04-16
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