A5101522448- Virus-based gene therapy research
- Virology and Viral Diseases
- Respiratory viral infections research
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Allergic Rhinitis and Sensitization
- Parvovirus B19 Infection Studies
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
Hubei University of Science and Technology
2023
MRC University of Glasgow Centre for Virus Research
2019-2022
University of Birmingham
2019
Viruses have evolved to inhibit cellular DNA damage response pathways that possess antiviral activities and utilize proviral activities. Adenovirus has evolved, primarily, by engaging with the ubiquitin-proteasome system promoting degradation of key proteins. differentially regulates ATR signaling during infection. The adenovirus E1B-55K binding protein E1B-AP5 participates in activated infection, while 12 E4orf6 negates Chk1 activation proteasome-dependent activator TOPBP1. studies detailed...
The rapid transmission of measles poses a great challenge for elimination. Thus, testing is required to screen the health status in population during outbreaks. A pseudotype-based virus neutralisation assay was used measure neutralising antibody titres serum samples collected from healthcare workers Sheffield outbreak 2016. Vesicular stomatitis (VSV) pseudotypes bearing haemagglutinin and fusion glycoproteins (MeV) carrying luciferase marker gene were prepared; titre defined as dilution...