A5061931413- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Medical Image Segmentation Techniques
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Genetic Neurodegenerative Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Medical Imaging Techniques and Applications
- Neurological disorders and treatments
- Childhood Cancer Survivors' Quality of Life
- Liver Disease Diagnosis and Treatment
- Peripheral Nerve Disorders
- Dysphagia Assessment and Management
- Restless Legs Syndrome Research
- Digital Marketing and Social Media
- Liver Disease and Transplantation
- Peripheral Neuropathies and Disorders
- Advanced Neural Network Applications
- Mitochondrial Function and Pathology
- Powdery Mildew Fungal Diseases
- Child Nutrition and Feeding Issues
- Recommender Systems and Techniques
- Autoimmune Neurological Disorders and Treatments
- Image and Object Detection Techniques
Indira Gandhi Medical College
2024
Lancashire Teaching Hospitals NHS Foundation Trust
2013-2022
Lucerne University of Applied Sciences and Arts
2017-2021
Royal Preston Hospital
2007-2018
University of Basel
2012-2016
Salford Royal Hospital
2013
University of Birmingham
2013
Pakistan Institute of Engineering and Applied Sciences
2005
Objectives: Using the Wilson and Cleary model linking clinical variables to quality of life, we explored associations between physical psychological factors, disability, perceived health life in ALS/MND. Methods: The ongoing UK study Trajectories Outcomes Neurological Conditions (TONiC) recruited participants with ALS/MND complete a questionnaire pack including demographic factors several patient reported outcome measures (PROMs); clinician provided data on disease onset type duration since...
A 56-year-old man presented with a 3-day history of progressive tingling the hands, unsteadiness, and diplopia. He was initially diagnosed clinically Miller Fisher Syndrome (MFS) but later developed limb weakness consistent Guillain-Barre (GBS) subsequently reduced consciousness Bickerstaff's brainstem encephalitis (BBE). Neurophysiology revealed an axonal motor sensory neuropathy, in keeping Acute Motor Sensory Axonal Neuropathy (AMSAN) variant GBS. We believe that our patient had...
Objective The precise relationship between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is incompletely understood. association has been described as a continuum, yet data suggest that this may be an oversimplification. Direct comparisons patients who have behavioural variant FTD (bvFTD) with without ALS are rare. This prospective comparative study aimed to determine whether there phenotypic differences in cognition behaviour FTD-ALS bvFTD alone. Methods Patients or...
Our objective was to better understand UK-wide practice in managing sialorrhoea motor neuron disease among specialist clinicians. We used a survey of neurologists the UK with special interest designed establish clinicians' attitudes towards treatment options and resources for management. Twenty-three clinicians replied, representing 21 centres. Sixteen centres were MND Care Centres. Clinicians estimated seeing total 1391 newly diagnosed patients 2011. One hundred ninety-three described....
Objectives: The World Health Organization Quality of Life-BREF Scale (WHOQOL-BREF) is a generic QOL measure with four domains covering Physical, Psychological, Social and Environment. Providing the opportunity to contrast QoL other conditions, or population norms, current study had three aims: 1) can established WHOQOL-BREF be validated within large ALS/MND population; 2) total score 3) they provide interval level measurement? Methods: Data were obtained from Trajectories Outcomes in...
Objectives To examine the usefulness of Edinburgh Cognitive and Behavioral Amyotrophic Lateral Sclerosis (ALS) Screen (ECAS) as a cognitive screening tool for detection behavioral variant frontotemporal dementia (bvFTD). A secondary aim was to determine whether people with FTD combined ALS (ALS-FTD) exhibit similar ECAS profile that bvFTD alone. Methods: Patients ALS-FTD healthy controls were recruited. Participants administered ECAS, which comprises tests language, verbal fluency, executive...
Objectives Spasticity is a common and disabling feature of amyotrophic lateral sclerosis (ALS). There are currently no validated ALS-specific measures spasticity. The aim this study was to develop use self-report outcome measure for spasticity in ALS. Methods Following semi-structured interviews with 11 ALS patients, draft scale administered across clinics the UK. Internal validity examined using Rasch model. numerical rating (NRS) Leeds (LSS) were co-administered. final used path model...
### Learning point for clinicians Lower limb weakness can be a presenting feature of various vascular syndromes affecting the spinal cord, lumbosacral roots or plexus. Acute bilateral plexopathy (LSP) secondary to aortoiliac occlusive disease is rare presentation and mimic an acute cord cauda equina syndrome. A 47-year-old gentleman with history hypertension, type 2 diabetes mellitus, hypercholesterolemia, coronary artery left iliofemoral bypass woke up discomfort, numbness severe both...
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive cognitive, behavioural and motor dysfunction (1). It a trinucleotide repeat as...
Introduction: Dyspnea (or breathlessness) due to progressive neuromuscular respiratory failure is common in amyotrophic lateral sclerosis (ALS). It associated with anxiety, depression and reduced quality of life (QoL). For effective treatment, it essential understand the relationships between dyspnea, QoL.Methods: The UK Trajectories Outcomes Neurological Conditions-ALS study (TONiC-ALS) collected self-report measures from patients ALS. Ordinal scales were transformed interval-scaled...
Image registration is a powerful tool in medical image analysis and facilitates the clinical routine several aspects. There are many well established elastic methods, but none of them can so far preserve discontinuities displacement field. These appear particular at organ boundaries during breathing induced motion. In this paper, we exploit fact that motion segmentation could play guiding role discontinuity preserving registration. The embedded continuous cut framework guaranteeing convexity...
In this paper we propose a novel segmentation method that integrates prior shape knowledge obtained from 3D statistical model into the Markov Random Field (MRF) framework to deal with severe artifacts, noise and deformations. The is learned using Probabilistic Principal Component Analysis (PPCA), which allows us reconstruct optimal compute remaining variance of partial information. model, its variance, can then be used constrain space, more efficient update as compared regularization-based...
Image registration is a powerful tool in medical image analysis and facilitates the clinical routine several aspects. There are many well established non-rigid methods, but those which able to preserve discontinuities displacement field rather rare. This paper deals with nonrigid method, that can handle motion appear particular at organ boundaries during breathing induced motion. Due fact segmentation could play guiding role discontinuity preserving registration, we therefore embed method...
Aim: To investigate whether the World Health Organization Disability Assessment Schedule 2.0 (WHODAS) can provide interval level measurement of disability in Amyotrophic Lateral Sclerosis (ALS), allowing parametric analyses. Methods: Data on WHODAS 12, 32, and 36-item versions, from 1120 patients studied at one or more time points, were fit to Rasch model comparisons made against ALSFRS-R, King's staging, mortality. Trajectory modeling was undertaken for a newly diagnosed (≤6 months) cohort...
Diabetic amyotrophy is a distinctive form of diabetic neuropathy. It characterised by weakness and wasting proximal muscles the lower limbs with associated pain. We report case an elderly patient unusual presentation amyotrophy. He presented myoclonic jerks recurrent falls. Examination findings electrophysiological studies were consistent diagnosis responded well to steroids marked improvement in strength limb complete resolution jerks. presenting as has been rarely reported before.
Medical image segmentation is generally an ill-posed problem that can only be solved by incorporating prior knowledge. The ambiguities arise due to the presence of noise, weak edges, imaging artifacts, inhomogeneous interior and adjacent anatomical structures having similar intensity profile as target structure. In this paper we propose a novel approach segment masseter muscle using graph-cut additional 3D shape priors in CT datasets, which robust noise; artifacts; deformations. main...