A5008731573- Life Cycle Costing Analysis
- Periodontal Regeneration and Treatments
- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Dental Implant Techniques and Outcomes
- Energy Efficiency and Management
- Oral and Maxillofacial Pathology
- Oral and gingival health research
- Antimicrobial Peptides and Activities
- T-cell and B-cell Immunology
- Diverse Research and Applications
- Diverse Education and Engineering Focus
- Offshore Engineering and Technologies
- Sustainable Building Design and Assessment
- BIM and Construction Integration
- Facilities and Workplace Management
- Immune Cell Function and Interaction
- Bone Tissue Engineering Materials
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Spacecraft and Cryogenic Technologies
- Nuclear and radioactivity studies
- Bone health and treatments
- Global Energy and Sustainability Research
- Airway Management and Intubation Techniques
University of Tennessee Health Science Center
2022-2024
Bioscience Research
2024
American Dental Education Association
2023
John Wiley & Sons (United States)
2023
University of Washington
2004-2022
University of New Mexico
2021
Public Health England
2015
United States Army
2004-2013
Pacific Northwest National Laboratory
1990-2011
National Technical Information Service
2011
Abstract Immunotherapies have achieved remarkable successes in the treatment of cancer, but major challenges remain 1,2 . An inherent weakness current approaches is that therapeutically targeted pathways are not restricted to tumours, also found other tissue microenvironments, complicating 3,4 Despite great efforts define inflammatory processes tumour microenvironment, understanding tumour-unique immune alterations limited by a knowledge gap regarding cell populations inflamed human tissues....
Porphyromonas gingivalis is a gram-negative bacterium strongly associated with periodontitis, chronic inflammatory disease of the tissue surrounding tooth root surface. Lipopolysaccharide (LPS) obtained from P. unusual in that it has been shown to display an amount lipid A heterogeneity containing both tetra- and penta-acylated structures. In this report, structures facilitate E-selectin expression whereas tetra-acylated do not. Furthermore, are potent antagonists for expression. Both...
Abstract A biologic is a therapeutic agent with biological activity that administered to achieve an enhanced regenerative or reparative effect. The use of biologics has progressively become core component contemporary periodontal practice. However, some questions remain about their safety, indications, and effectiveness in specific clinical scenarios. Given availability for routine the existing amount related evidence, goal this American Academy Periodontology (AAP) best evidence consensus...
Application of recombinant human bone morphogenetic protein-2 (rhBMP-2) has been associated with significant adverse events in craniofacial settings, including swelling and seroma formation. Recent work demonstrated an inverse relationship between formation/maturation rhBMP-2 dose, frequency/severity increasing rising dose.The objective this study was to determine the most effective dose for soak-loaded onto absorbable collagen sponge (ACS) carrier using established defect model.One hundred...
CCR5 is thought to play a central role in orchestrating migration of cells response inflammation. antagonists can reduce inflammatory disease processes, which has led an increased interest using wide range inflammation-driven diseases. Paradoxically, these appear function without negatively affecting host immunity at barrier sites. We reasoned that the resolution this paradox may lie CCR5+ T cell populations permanently reside tissues. used single-cell analysis approach examine human...
Aim To determine the potential of recombinant human bone morphogenetic protein‐2 (rh BMP ‐2) soak‐loaded on to an absorbable collagen sponge ( ACS ) induce local formation compared with clinical reference demineralized matrix DBM and investigate additive/synergistic effects exogenous parathyroid hormone PTH ). Methods Critical‐size (8 mm), through‐through calvaria osteotomy defects in 160 adult male S prague– D awley rats were randomized receive one eight interventions: rh ‐2/ , or serve as...
The objective of this study was to determine the contribution commensal bacteria innate defense status gingival tissue by examining expression host mediators in germ-free and conventionally reared groups both BALBc/ByJ SCID C.B17 mice.Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) utilized constitutive levels within each set (N = 5) for: E-selectin, P-selectin, interleukin-(IL)-8 homologue, tumor necrosis factor-alpha, IL-1beta, intercellular adhesion...
Background and Objective Specifics of the biochemical pathways that modulate collagen cross‐links in periodontal ligament ( PDL ) are not fully defined. Better knowledge post‐translational modifications give its distinct tissue properties is needed to understand pathogenic mechanisms human destruction disease. In this study, phenotypes mouse type I were surveyed using mass spectrometry. a highly specialized connective joins tooth cementum alveolar bone. The main function support within bone...
Abstract Background Previous studies document the therapeutic potential of recombinant human bone morphogenetic protein‐2 (rh BMP ‐2) in an absorbable collagen sponge ( ACS ) carrier for indications axial and appendicular skeleton. Nevertheless, does not comprise structural integrity to adequately support formation onlay indications. The objective this study was evaluate local osseointegration following surgical implantation rh ‐2 soak‐loaded onto a compression resistant matrix CRM )....
Abstract Mucosal-associated invariant T (MAIT) cells acquire effector function in response to proinflammatory signals, which synergize with TCR-mediated signals. We asked if cell-intrinsic regulatory mechanisms exist curtail MAIT cell akin the activation-induced expression of inhibitory receptors by conventional cells. examined human from blood and oral mucosal tissues RNA sequencing found differential immunoregulatory genes, including CTLA-4, isolated tissue. Using an ex vivo experimental...
Host responses following the recognition of bacterial lipopolysaccharide can range from acute inflammation to septic shock. The aim this study was evaluate ability KSL-W decapeptide bind and block endotoxic effects lipopolysaccharide.An enzyme-linked immunosorbent assay-based binding assay using fluorescently labeled detect adsorbed Escherichia coli O55:B5 employed. A commercially available recombinant Factor C detection assay, hemagglutination rabbit erythrocytes as well E-selectin...
Abstract Objective Air medical transport of patients with known or suspected coronavirus disease 2019 (COVID‐19) likely represents a high‐risk exposure to crew members as aircraft cabins are quite small resulting in close personal contact. The actual risk is not known. Methods We conducted an institutional review board‐exempt, retrospective study air COVID‐19 by 8 programs the Four Corners Region determine number symptomatic among compared total time. All used similar routine protective...
Little is known regarding the success, failure, or complication rates of advanced implant procedures in patients after discontinuation therapy long-term medications for treatment chronic myelogenous leukemia (CML). This case report presents initial results a involving placement mandible and maxilla as well reduction palatal oral pigmentation patient discontinuing tyrosine kinase inhibitor (TKI) CML.A 57-year-old male was referred to Department Periodontics, University Washington, Seattle, an...
Placement of endosseous dental implants in edentulous areas the anterior maxilla poses a unique challenge due to variations amount residual alveolar bone. Implant position becomes crucial cases demanding high esthetic results but possessing minimal ridge width or requiring augmentation. Recent advances spiral tomography have allowed for more precise planning and placement these challenging areas.The purpose this report is describe series clinical which was utilized implants. Two will be...
Background Rapid Sequence Airway (RSA) describes the administration of an induction agent and paralytic followed by intended primary placement extraglottic airway device rather than endotracheal tube. The purpose this study was to determine success rates for prehospital RSA. secondary goal aspiration among patients managed with RSA.Methods Adult pediatric RSA cases between 2005 2017 reported quality assurance registry from one ground air agency were reviewed. Success defined as ability...
BACKGROUND The P‐Capt prion reduction filter (MacoPharma) removes infectivity in model systems. This independent evaluation assesses removal from endogenously infected animal blood, using CE‐marked filters, and replicates the proposed use of within UK Blood Services. STUDY DESIGN AND METHODS Two units generated 263K scrapie–infected hamsters, were processed leukoreduction filters (LXT‐quadruple, MacoPharma). Approximately 100 mL removed plasma was added back to red blood cells (RBCs)...