A5003548772- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
Tri-Institutional PhD Program in Chemical Biology
2024
Cornell University
2024
Rockefeller University
2024
ABSTRACT The three-dimensional structure of chromatin has emerged as an important feature eukaryotic gene regulation. Recent technological advances in DNA sequencing-based assays have revealed locus- and state-specific structural patterns at the length scale a few nucleosomes (∼1 kb). However, interpreting these data sets remains challenging. Radiation-induced correlated cleavage (RICC-seq) is one such assay that maps DNA-DNA-contacts base pair resolution by sequencing single-stranded...
The computational modeling of chromatin structure is highly complex and challenging due to the hierarchical organization chromatin, which reflects its diverse biophysical principles, as well inherent dynamism, underlies complexity. variety methods for modeling, are based on different approaches, assumptions scales suggests that there a necessity comprehensive benchmark. This inspired us conduct project at NIH-funded 4D Nucleome Hackathon March 18-21, 2024 University Washington in Seattle,...