A5044536478- Connexins and lens biology
- Autoimmune and Inflammatory Disorders Research
- Nicotinic Acetylcholine Receptors Study
- Photoreceptor and optogenetics research
- Ion channel regulation and function
- Exercise and Physiological Responses
- COVID-19 Clinical Research Studies
- Pituitary Gland Disorders and Treatments
- Long-Term Effects of COVID-19
- Neurogenesis and neuroplasticity mechanisms
- Spondyloarthritis Studies and Treatments
- Heat shock proteins research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Glioma Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Mycobacterium research and diagnosis
- Neurological Disorders and Treatments
- Supramolecular Self-Assembly in Materials
- TGF-β signaling in diseases
- Platelet Disorders and Treatments
- Axon Guidance and Neuronal Signaling
- Sympathectomy and Hyperhidrosis Treatments
- Rheumatoid Arthritis Research and Therapies
- Diagnosis and treatment of tuberculosis
- Pain Management and Opioid Use
Université de franche-comté
2024
Hôpital Pasteur
2024
Inserm
2024
Centre Hospitalier Universitaire de Besançon
2020-2021
Université Bourgogne Franche-Comté
2021
L'Hôpital Nord Franche-Comté
2016-2020
Yeshiva University
1984-2000
Albert Einstein College of Medicine
1987-2000
National Institutes of Health
1975
Gap junction channels provide a pathway for exchange of ions and small molecules between coupled cells, this is believed to be critical normal tissue growth development. As test role gap junction-mediated intercellular communication in control cell growth, we have compared rates communication-deficient human tumor cells (SKHep1) with clones stably transfected cDNA encoding the rat liver protein connexin 32. In culture, parental were similar. However, when sizes tumors evaluated following...
Oligodendrocytes, the myelin-forming glia of brain, are connected by gap junctions in situ and culture. Cultured oligodendrocytes from adult bovine porcine brains were studied using immunocytochemical, molecular, electrophysiological techniques order to characterize junction types. The expression connexin32 was substantiated detection low, but significant, signals connexin-specific probes Northern Western blot analyses. Connexin43, which comprises astrocytes, not detectable pure...
The choice of which neurotransmitters will be produced by a developing neuron is influenced the microenvironment neuron. In this study we show that neuronal contact with membrane-associated molecules promotes expression peptidergic and cholinergic traits. Treatment cultured neonatal rat sympathetic neurons plasma membranes derived from adult spinal cord or ganglia induced peptide transmitter substance P increased levels biosynthetic enzyme choline acetyltransferase. transmitter-stimulating...
Electrotonic coupling between pairs of sympathetic neurons dissociated from superior cervical ganglia neonatal rats is rare when cells are cultured for 2 weeks in a nutrient medium plus serum and common the same period serum-free defined medium. This with five added factors (progesterone, transferrin, putrescine, insulin, selenium). When singly to serum-containing medium, insulin and, lesser extent, selenium promote development electrotonic dye coupling. The effect obtained doses as low 0.01...
The gating properties of macroscopic and microscopic gap junctional currents were compared by applying the dual whole cell patch clamp technique to pairs neonatal rat Schwann cells. In response transjunctional voltage pulses (Vj), decayed exponentially with time constants ranging from < 1 10 s before reaching steady-state levels. relationship between normalized conductance (Gss) (Vj) was well described a Boltzmann e-fold decay per 10.4 mV, representing an equivalent charge 2.4. At Vj...
Multipotent neural progenitor cells become progressively more biased towards a glial fate during development coincident with an increase in expression of the epidermal growth factor receptor (EGFR). To determine whether differences lineage commitment from different stages are causally related to EGFR and generation glia is EGFR-dependent, we used EGFR-specific tyrosine kinase inhibitor, PD158780, block activation cells. Treatment cultured neonatal PD158780 completely blocked EGF-induced...
Multipotent neural progenitor cells become progressively more biased towards a glial fate during development coincident with an increase in expression of the epidermal growth factor receptor (EGFR). To determine whether differences lineage commitment from different stages are causally related to EGFR and generation glia is EGFR-dependent, we used EGFR-specific tyrosine kinase inhibitor, PD158780, block activation cells. Treatment cultured neonatal PD158780 completely blocked EGF-induced...
Abstract The aim of the study was to assess impact (frequency and severity) Covid-19 on patients treated with biological Disease Modifying Anti-Rheumatic Drugs (bDMARDs) for inflammatory rheumatic disease compare it a control group consisting musculoskeletal conditions not bDMARDs.Patients methods:A case in 200 outpatients conditions. 100 consecutive who have been bDMARDs other did take were asked complete 15-item standardized questionnaire regarding demographic data. following information...