A5081161652- Nicotinic Acetylcholine Receptors Study
- Tryptophan and brain disorders
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Atrial Fibrillation Management and Outcomes
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Digital Imaging in Medicine
- Neurotransmitter Receptor Influence on Behavior
- Surgical Simulation and Training
- Health Systems, Economic Evaluations, Quality of Life
- SARS-CoV-2 and COVID-19 Research
- Spine and Intervertebral Disc Pathology
- Hormonal and reproductive studies
- Patient-Provider Communication in Healthcare
- Smoking Behavior and Cessation
- Molecular Communication and Nanonetworks
- Drug-Induced Adverse Reactions
- Educational Challenges and Innovations
- Cardiac electrophysiology and arrhythmias
- Palliative Care and End-of-Life Issues
- Polyomavirus and related diseases
- Inflammatory Myopathies and Dermatomyositis
- Elbow and Forearm Trauma Treatment
California Institute of Technology
2018-2023
University of Glasgow
2023
Barro Colorado Island
2023
Yale University
2022
Division of Chemistry
2020-2021
Radiation Oncology Associates
2021
United States Food and Drug Administration
2009-2018
Center for Drug Evaluation and Research
2014-2018
Royal Hospital for Children
2014
University Hospital Ayr
2010-2011
Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depressive disorder. The therapeutic mechanisms that take place before, during, or after SSRIs bind transporter (SERT) poorly understood, partially because no studies exist on cellular and subcellular pharmacokinetic properties of in living cells. We studied escitalopram fluoxetine using new intensity-based, drug-sensing fluorescent reporters targeted to plasma membrane,...
Abstract Menthol contributes to poor cessation rates among smokers, in part because menthol enhances nicotine reward and reinforcement. Mentholated tobacco products contain (−)-menthol (+)-menthol, varying proportions. We examined these two stereoisomers for their ability upregulate α4β2 nAChRs alter dopamine neuron firing frequency using long-term, low-dose (≤500 n m ) exposure that is pharmacologically relevant smoking. found upregulates while (+)-menthol does not. also decreases baseline...
The target for the "rapid" (<24 h) antidepressant effects of S-ketamine is unknown, vitiating programs to rationally develop more effective rapid antidepressants. To describe a drug's target, one must first understand compartments entered by drug, at all levels-the organ, cell, and organelle. We have, therefore, developed molecular tools measure subcellular, organellar pharmacokinetics S-ketamine. are genetically encoded intensity-based S-ketamine-sensing fluorescent reporters, iSKetSnFR1...
Levels of medical mistrust have historically been higher among racial/ethnic minority patients compared with whites, largely owing to societal and health system inequities history discrimination or experimentation. However, recently trust in physicians has declined the United States general. We investigated a large cohort cancer residing Texas.A sample diagnosed Texas were identified from Cancer Registry 1344 returning surveys between March 2017 2020. The multiscale inventory was mailed each...
Introduction A target international normalized ratio ( INR ) of 2–3 has been recommended for patients with atrial fibrillation AF and risk factors thromboembolism. This recommendation is largely based on evidence from observational studies a decade ago. study utilized collective data modern trials warfarin controls to examine the relationship anticoagulation, as assessed by , clinical outcome events interest. Methods Data warfarin‐treated three supporting approval dabigatran (Pradaxa),...
Fractures of the proximal third ulna and radius with associated anterior radial head dislocation are uncommon in children. Early recognition appropriate management essential to prevent long-term consequences loss forearm rotation, cubitus valgus, elbow instability chronic pain. We present case a 3-year-old Caucasian boy who attended emergency department following an un-witnessed fall, resulting right pain, swelling deformity. Clinical radiological examination revealed Monteggia type IV...
A 25-year-old male bodybuilder was admitted in septic shock. He had marked limitation of left shoulder movement with non-fluctuant swelling extending from the acromio-clavicular joint to postero-lateral and anterior deltoid. Lesions consistent herpes labialis were also noted. computed tomography scan demonstrated collections both gas fluid within deltoid muscle numerous pockets soft tissues conforming fascial planes (Figure 1). On further questioning he injecting himself anabolic steroids...
A man in his 70s presented to a dermatology outpatient clinic with new rash developing over 4 weeks, associated weakness and swallowing difficulties. He had background of Merkel cell carcinoma (MCC) diagnosed 2 years prior, recent CT suspicious for pancreatic metastasis. On examination, there were urticated plaques involving the face, neck, back abdomen. Gottron sign papules, Holster periorbital erythema also present. There was proximal muscle dysphagia, requiring urgent inpatient assessment...
Recent, non-peer-reviewed reports and meta-analyses suggest that smoking may reduce the risk of hospitalization with COVID-19, because prevalence among hospitalized COVID-19 is less than general population. However, there are two alternative classes explanations for this phenomenon. Class (1) failure to report, or accurately record, history during emergency hospital admissions other interviews. Face-to-face interviews can introduce bias into responses attitudinal behavioral questions not...
Thoracotomy is considered one of the most painful surgical procedures and can cause debilitating chronic post-surgical pain lasting months or years postoperatively. Aggressive management acute resulting from thoracotomy may reduce likelihood developing pain. This trial compares two commonly used modes analgesia provision at time (thoracic epidural blockade (TEB) paravertebral (PVB)) in terms their clinical cost-effectiveness preventing post-thoracotomy pain.TOPIC 2 a multi-centre,...
ABSTRACT Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depressive disorder (MDD). The therapeutic mechanisms that take place before, during, or after SSRIs bind transporter (SERT) poorly understood, partially because no studies exist of cellular and subcellular pharmacokinetic properties in living cells. We studied escitalopram fluoxetine using new intensity- based drug-sensing fluorescent reporters (“iDrugSnFRs”)...
Abstract Background Thoracotomy is considered one of the most painful surgical procedures and can cause debilitating chronic post-surgical pain lasting months or years postoperatively. Aggressive management acute resulting from thoracotomy may reduce likelihood developing pain. This trial compares two commonly used modes analgesia provision at time (thoracic epidural blockade (TEB) paravertebral (PVB)) in terms their clinical cost effectiveness preventing post-thoracotomy Methods TOPIC 2 a...