A5006328603- Obesity and Health Practices
- Behavioral Health and Interventions
- Obesity, Physical Activity, Diet
- Smoking Behavior and Cessation
- Physical Activity and Health
- Health Promotion and Cardiovascular Prevention
- Mobile Health and mHealth Applications
- Pain Management and Opioid Use
- Eating Disorders and Behaviors
- Diabetes Management and Research
- Anesthesia and Pain Management
- Workplace Health and Well-being
- Chronic Disease Management Strategies
- Homelessness and Social Issues
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Spine and Intervertebral Disc Pathology
- School Health and Nursing Education
- Health Policy Implementation Science
- Neonatal skin health care
- Vaccine Coverage and Hesitancy
- Bipolar Disorder and Treatment
- Influenza Virus Research Studies
- Breastfeeding Practices and Influences
- Nicotinic Acetylcholine Receptors Study
- Treatment of Major Depression
Cancer Research UK Clinical Trials Unit
2020-2025
University of Birmingham
2020-2025
University of Oxford
2016-2020
Nuffield Health
2017
Abstract Background A novel ‘whole day’ approach that could motivate the public to be more physically active is Snacktivity™. The Snacktivity™ encourages individuals accumulate 150 min of physical activity in short 2–5-min ‘snacks’ moderate-vigorous intensity (MVPA) throughout day/week. Method randomised controlled trial assess feasibility/acceptability a intervention and processes was conducted. aimed recruit 80 inactive adults from healthcare services via social media. Participants were or...
Background Care following transient ischaemic attack (TIA) and minor stroke is variable often leaves patients feeling abandoned uncertain. We developed a theoretically-informed, multifaceted intervention which comprised nurse-led, structured follow-up at 4 weeks after TIA/minor to identify address patient needs. This study evaluated the feasibility acceptability of both procedures inform future randomised controlled trial. Method conducted multicentre, with mixed-methods process evaluation...
<title>Abstract</title> Randomised controlled trials (RCTs) aiming to address the multiple health and social challenges of people experiencing homelessness (PEH) are lacking. Here we report findings from a multicentre, open, pilot RCT. The intervention involved Independent Prescriber Pharmacist National Health Service working on outreach in partnership with dedicated workers Homeless Voluntary Charity or Social Enterprises (HVCSEs) (Pharmacist third sector charity worker integrated Outreach...
Abstract Background Many people do not regularly participate in physical activity, which may negatively impact their health. Current activity guidelines are focused on promoting weekly accumulation of at least 150 min moderate to vigorous intensity (MVPA). Whilst revised guidance now recognises the importance making small changes behaviour, still focuses adults needing achieve MVPA per week. An alternative ‘whole day’ approach that could motivate public be more physically active, is a...
Background Public health guidance acknowledges the benefits of physical activity any duration. We have proposed a whole-day approach to promoting called Snacktivity ™ , which encourages frequent 2–5 minute ‘activity snacks’ moderate-to-vigorous intensity. Methods Using repeated semi-structured interviews and think aloud protocol, this study aimed understand participants’ experiences integrating into daily life, provide insights refine delivery interventions. Physically inactive adults...
Background Urine collection devices (UCDs) are being marketed and used in clinical settings to reduce urine sample contamination, despite inadequate supporting evidence. Aim To determine whether UCDs, compared with standardised instructions for collection, the proportion of contaminated samples. Design setting Single-blind randomised controlled trial general practices England Wales. Method Women aged ≥18 years presenting symptoms attributable urinary tract infection (UTI) were (1:1:1) use...
Introduction The global prevalence of obesity has risen significantly in recent decades. There is a pressing need to identify effective interventions treat established that can be delivered at scale. aim the Doctor Referral Overweight People Low-Energy Treatment (DROPLET) study determine clinical effectiveness, feasibility and acceptability referral low-energy total diet replacement programme compared with usual weight management primary care. Methods analysis DROPLET trial randomised...
Abstract Background People experiencing homelessness (PEH) have complex health and social care needs most die in their early 40 s. PEH frequently use community pharmacies; however, evaluation of the delivery structured, integrated, holistic intervention has not been previously undertaken pharmacies for PEH. PHOENIx (Pharmacy Homeless Outreach Engagement Non-medical Independent prescribing Rx) delivered tested Glasgow, Scotland, by NHS pharmacist independent prescribers third sector support...
Guidelines recommend that clinicians should make brief opportunistic behavioural interventions to patients who are obese increase the uptake of effective weight loss programmes. The objective was assess effect this policy on socioeconomic equity. One thousand eight hundred eighty-two consecutively attending with obesity and were not seeking support for from their GP enrolled in a trial. Towards end each consultation, GPs randomly assigned participants one two 30-s interventions. In active...
ABSTRACT Introduction There is a paucity of research on and limited understanding patient public involvement (PPI) in the context homelessness and, particular, direct people with lived living experience (PEH) as expert advisors. We aim to report outcomes reflections from advisory panel (LEAP) meetings PPI activities, held throughout study lifecycle pilot randomised‐controlled trial (RCT) focused evaluating integrated health practical support for PEH. Methods Community Pharmacy Homeless...
Objective Helping people to change their health behaviours is becoming a greater feature within the role of professionals, including through whole system initiatives such as Making Every Contact Count. Health services provide an ideal setting routinely promote behaviours, physical activity. Snacktivity novel approach that promotes small bouts activity (activity snacks) throughout day. This study explored professionals’ initial experiences delivering intervention routine consultations. A...
Abstract Objective Patients with ANCA-associated vasculitis (AAV) experience high levels of fatigue, despite disease remission. This study assessed the feasibility and acceptability a definitive randomized controlled trial behavioural-based physical activity intervention to support fatigue self-management in AAV patients. Methods patients remission (Multidimensional Fatigue Inventory-20 general domain ≥14) were randomly allocated or standard care this single-centre open-label study. The...
Nicotine preloading means using nicotine replacement therapy prior to a quit date while smoking normally. The aim is reduce the drive smoke, thereby reducing cravings for after day, which are main cause of early relapse. A systematic review showed inconclusive and heterogeneous evidence that was effective little mechanism action, with no cost-effectiveness data. To assess (1) effectiveness, safety tolerability in routine NHS setting relative usual care, (2) mechanisms action (3) preloading....
Weight loss programmes appeal mainly to women, prompting calls for gender-specific programmes. In the United Kingdom, general practitioners (GPs) refer nine times as many women men community weight GPs endorsement and offering systematically could reduce this imbalance. trial, consecutively attending patients in primary care with obesity were invited 1882 enrolled randomized one of two opportunistic 30-second interventions support given by consultations unrelated weight. arm, clinicians...
Introduction People who experience transient ischaemic attack (TIA) and minor stroke have limited follow-up despite rapid specialist review in hospital. This means they often unmet needs feel abandoned following discharge. Care after TIA/minor include information provision (diagnosis risk), prevention (medication lifestyle change) holistic care (residual problems return to work or usual activities). protocol describes a feasibility study process evaluation of an intervention support people...
Abstract Background The prevalence of obesity in women continues to rise and pregnancy is a high-risk time for excessive weight gain. period after childbirth represents an opportunity offer support manage their weight. primary aim here was investigate the acceptability feasibility delivering self-management intervention postnatal loss, embedded within national child immunisation programme. Methods research involved randomised controlled cluster trial. Data were collected at baseline 3 months...
Introduction On average women retain 5 to 9 kg 1 year after giving birth which can increase the risk of later obesity and chronic diseases. Some previous trials in this population have been effective reducing weight, but are too intensive costly deliver at scale. There is a need for low-cost interventions facilitate weight loss population. Methods analysis The primary aim assess feasibility delivering management intervention overweight/obese postnatal within child immunisation appointments....
Abstract Background Obstructive sleep apnoea (OSA) is very common in patients with type 2 diabetes (T2D). We and others have shown that OSA was associated diabetes-related microvascular complications T2D cross-sectional longitudinal studies compliance continuous positive airway pressure (CPAP) reduced the progression of complications. Hence, we hypothesised adequate CPAP reduces development complication T2D. Methods SLEEP a cohort study embedded feasibility, open-label, parallel-arm,...
<title>Abstract</title> <bold>Rationale</bold> Gold standard treatment for chronic obstructive pulmonary disease (COPD) includes a supported self-management plan to enable patients recognise and treat acute exacerbations (AECOPD). The Predict & Prevent trial was designed provide definitive randomised clinical of personalised early warning decision support system, COPDPredict<sup>TM</sup>. <bold>Methods</bold> Adults with ≥1 AECOPD or COPD admission were randomly assigned in 1:1 ratio use...
Background Staff sickness absenteeism and presenteeism (attending work while unwell) incur high costs to the NHS, are associated with adverse patient outcomes have been exacerbated by COVID-19 pandemic. The main causes mental musculoskeletal ill health cardiovascular risk factors common. Objectives To undertake a feasibility study inform design of definitive randomised controlled trial effectiveness cost screening clinic in reducing amongst National Health Service staff. Design Individually...
Abstract Background Depressive episodes are common after first-episode psychosis (FEP), affecting more than 40% of people, adding to individual burden, poor outcomes, and healthcare costs. If the risks developing depression were lower, this could have a beneficial effect on morbidity mortality, as well improving outcomes. Sertraline is selective serotonin reuptake inhibitor first-line medication for treatment in adults. It has been shown be safe when co-prescribed with antipsychotic...