A5019043895- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Nicotinic Acetylcholine Receptors Study
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Click Chemistry and Applications
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Visual perception and processing mechanisms
- Synthesis and Biological Evaluation
- Neural and Behavioral Psychology Studies
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Anatomy and Medical Technology
- COVID-19 Pandemic Impacts
- Vagus Nerve Stimulation Research
- Complex Systems and Decision Making
- Molecular Sensors and Ion Detection
- Smoking Behavior and Cessation
- Augmented Reality Applications
- Lipid Membrane Structure and Behavior
- Eating Disorders and Behaviors
- COVID-19 and Mental Health
Stanford University
2015-2023
University of Southern California
2018-2023
California Institute of Technology
2020-2023
ORCID
2022
University of California, Davis
2015
University of Minnesota
2013
Abstract Background Investigations into the effect of deep brain stimulation (DBS) on subthalamic (STN) beta (13‐30 Hz) oscillations have been performed in perioperative period with subject tethered to equipment. Using an embedded sensing neurostimulator, this study investigated whether power was similar different resting postures and during forward walking freely moving subjects Parkinson's disease (PD) STN DBS attenuated a voltage‐dependent manner. Methods Subthalamic local field...
Reward hypersensitization is a common feature of neuropsychiatric disorders, manifesting as impulsivity for anticipated incentives. Temporally specific changes in activity within the nucleus accumbens (NAc), which occur during anticipatory periods preceding consummatory behavior, represent critical opportunity intervention. However, no available therapy capable automatically sensing and therapeutically responding to this vulnerable moment time when anticipation-related neural signals may be...
Pupil diameter has long been used as a metric of cognitive processing. However, recent advances suggest that the sources change in pupil size may reflect LC-NE function and calculation unexpected uncertainty decision processes (Aston-Jones & Cohen, 2005b; Yu Dayan, 2005). In current experiments, we explored role attentional selection on task-evoked changes during visual search. We found were related to measured by reaction time performance accuracy (Experiments 1-2). Control analyses...
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method examine the cellular subcellular pharmacokinetic properties these compounds in living cells. Here, we developed new intensity-based drug-sensing fluorescent reporters (iDrugSnFRs) nicotinic dianicline, cytisine, two cytisine derivatives – 10-fluorocytisine...
Bradykinesia is the major cardinal motor sign of Parkinson disease (PD), but its neural underpinnings are unclear. The goal this study was to examine whether changes in bradykinesia following long-term subthalamic nucleus (STN) deep brain stimulation (DBS) linked local STN beta (13-30 Hz) dynamics or a wider bilateral network dysfunction.
Abstract Objective To investigate the progression of neural and motor features Parkinson's disease in a longitudinal study, after washout medication bilateral subthalamic nucleus deep brain stimulation (STN DBS). Methods Participants with clinically established underwent implantation DBS leads (18 participants, 13 male) within STN using standard functional frameless stereotactic technique multi‐pass microelectrode recording. Both were connected to an implanted investigative sensing...
Clinical deep brain stimulation (DBS) technology is evolving to enable chronic recording of local field potentials (LFPs) that represent electrophysiological biomarkers the underlying disease state. However, little known about biophysical basis LFPs, or how patient’s unique anatomy and electrode placement impact recordings. Therefore, we developed a patient-specific computational framework analyze LFP recordings within clinical DBS context. We selected subject with Parkinson’s implanted...
Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depressive disorder. The therapeutic mechanisms that take place before, during, or after SSRIs bind transporter (SERT) poorly understood, partially because no studies exist on cellular and subcellular pharmacokinetic properties of in living cells. We studied escitalopram fluoxetine using new intensity-based, drug-sensing fluorescent reporters targeted to plasma membrane,...
High frequency subthalamic nucleus (STN) deep brain stimulation (DBS) improves the cardinal motor signs of Parkinson's disease (PD) and attenuates STN alpha/beta band neural synchrony in a voltage-dependent manner. While there is growing interest behavioral effects lower (60 Hz) DBS, little known about its effect on synchrony. Here we demonstrate for first time that during intra-operative 60 Hz one or more bands resting state were amplified PD. We recorded local field potentials (LFPs) from...
Closed-loop brain-responsive neurostimulation via the RNS System is a treatment option for adults with medically refractory focal epilepsy. Using novel technique, 2 Systems (2 neurostimulators and 4 leads) were successfully implanted in single patient bilateral parietal epileptogenic zones. In patients multiple zones, this technique allows additional options. Implantation can be done successfully, without telemetry interference, using proper surgical planning neurostimulator...
Current deep brain stimulation paradigms deliver continuous to structures ameliorate the symptoms of Parkinson's disease. This has undesirable side effects and decreases lifespan unit's battery, necessitating earlier replacement. A closed-loop stimulator that uses signals determine when based on occurrence could potentially address these drawbacks current technology. Attempts detect Parkinsonian tremor using recorded during implantation procedure have been successful. However, ability...
Recent, non-peer-reviewed reports and meta-analyses suggest that smoking may reduce the risk of hospitalization with COVID-19, because prevalence among hospitalized COVID-19 is less than general population. However, there are two alternative classes explanations for this phenomenon. Class (1) failure to report, or accurately record, history during emergency hospital admissions other interviews. Face-to-face interviews can introduce bias into responses attitudinal behavioral questions not...
Perceptually salient non-targets typically interfere with target processing, but such disruption can be mitigated by top-down knowledge that the item is not task-relevant (Geng and DiQuattro, 2010). This exploitation of statistical optimizes behavior thought to underwritten locus coeruleus – norepinephrine (LC-NE) innervation from neurons in frontal cortex (Aston-Jones Cohen, 2005; Minzenberg et al., 2009). The two different modes LC neuronal firing (i.e., tonic phasic) are correlated...
ABSTRACT Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method examine the cellular subcellular pharmacokinetic properties these compounds in living cells. Here, we developed new intensity-based drug sensing fluorescent reporters (“iDrugSnFRs”) nicotinic dianicline, cytisine, two cytisine derivatives –...
ABSTRACT Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depressive disorder (MDD). The therapeutic mechanisms that take place before, during, or after SSRIs bind transporter (SERT) poorly understood, partially because no studies exist of cellular and subcellular pharmacokinetic properties in living cells. We studied escitalopram fluoxetine using new intensity- based drug-sensing fluorescent reporters (“iDrugSnFRs”)...