A5014674537- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Diabetic Foot Ulcer Assessment and Management
- Balance, Gait, and Falls Prevention
- Muscle activation and electromyography studies
- Voice and Speech Disorders
- Gait Recognition and Analysis
- EEG and Brain-Computer Interfaces
- Cerebral Palsy and Movement Disorders
- Restless Legs Syndrome Research
- Advanced Sensor and Energy Harvesting Materials
Stanford University
2020-2024
Stanford Medicine
2021-2023
No biomarker of Parkinson's disease exists that allows clinicians to adjust chronic therapy, either medication or deep brain stimulation, with real-time feedback. Consequently, rely on time-intensive, empirical, and subjective clinical assessments motor behaviour adverse events therapies. Accumulating evidence suggests hypokinetic aspects their improvement therapy are related pathological neural activity in the beta band (beta oscillopathy) subthalamic nucleus. Additionally, effectiveness...
DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely person and overseas joining by video conferencing technology. The founded 2012 provides an open platform where clinicians, engineers researchers (from industry academia) can freely discuss current emerging deep brain stimulation (DBS) technologies as well the logistical ethical issues facing field. consensus among speakers that expanded its scope has been applied to multiple disorders effort...
Freezing of gait (FOG) is a debilitating symptom Parkinson's disease (PD) that often refractory to medication. Pathological prolonged beta bursts within the subthalamic nucleus (STN) are associated with both worse impairment and freezing behavior in PD, which improved deep brain stimulation (DBS). The goal current study was investigate feasibility, safety, tolerability burst-driven adaptive DBS (aDBS) for FOG PD.
Bradykinesia is the major cardinal motor sign of Parkinson disease (PD), but its neural underpinnings are unclear. The goal this study was to examine whether changes in bradykinesia following long-term subthalamic nucleus (STN) deep brain stimulation (DBS) linked local STN beta (13-30 Hz) dynamics or a wider bilateral network dysfunction.
Pathologically prolonged bursts of neural activity in the 8-30 Hz frequency range Parkinson's disease have been measured using high power event detector thresholds.This study introduces a novel method for determining beta baseline based on spectral that overlapped simulated 1/f spectrum. We used resting state local field potentials from people with and signal to measure burst durations, demonstrate how tuning parameters (i.e., bandwidth center frequency) affect compare duration distributions...
A deep brain stimulation system capable of closed loop neuromodulation is a type bidirectional computer interface (dBCI), in which neural signals are recorded, decoded and then used as the input commands for at same site brain. The challenge assuring successful implementation dBCIs Parkinson's disease (PD) to discover decode stable, robust reliable inputs that can be tracked during stimulation, optimize neurostimulation patterns parameters (control policies) motor behaviors interface,...
Abstract Objective To investigate the progression of neural and motor features Parkinson's disease in a longitudinal study, after washout medication bilateral subthalamic nucleus deep brain stimulation (STN DBS). Methods Participants with clinically established underwent implantation DBS leads (18 participants, 13 male) within STN using standard functional frameless stereotactic technique multi‐pass microelectrode recording. Both were connected to an implanted investigative sensing...
Background: The sequence effect is the progressive deterioration in speech, limb movement, and gait that leads to an inability communicate, manipulate objects, or walk without freezing of gait. Many studies have demonstrated a lack improvement from dopaminergic medication, however few studied metric over time investigated open-loop deep brain stimulation people with Parkinson’s disease (PD). Objective: To investigate whether worsens and/or improved on clinical (open-loop) (DBS). Methods:...
Emergent tremor in Parkinson's disease (PD) can occur during sustained postures or movements that are different from action tremor. Tremor contaminate the clinical rating of bradykinesia finger tapping. Currently, there is no reliable way isolating emergent and measuring cardinal motor symptoms based on voluntary only. In this study, we investigated whether repetitive alternating tapping (RAFT) a quantitative digitography (QDG) device could be reliably identified distinguished Ninety-six...
Impaired gait in Parkinson's disease is marked by slow, arrhythmic stepping, and often includes freezing of episodes where alternating stepping halts completely. Wearable inertial sensors offer a way to detect these changes novel deep brain stimulation (DBS) systems can respond with clinical therapy real-time, closed-loop fashion. In this paper, we present two DBS algorithms, one using arrhythmicity logistic-regression model detection as control signals. Benchtop validation results...
Assessment of motor signs in Parkinson's disease (PD) requires an in-person examination. However, 50% people with PD do not have access to a neurologist. Wearable sensors can provide remote measures some but require continuous monitoring for several days. A major unmet need is reliable metrics all cardinal signs, including rigidity, from simple short active task that be performed remotely or the clinic.
Increased beta band synchrony has been demonstrated to be a biomarker of Parkinson's disease (PD). This abnormal can often prolonged in long bursts activity, which may interfere with normal sensorimotor processing. Previous closed loop deep brain stimulation (DBS) algorithms used averaged power drive neurostimulation, were indiscriminate physiological (short) versus pathological (long) burst durations. We present closed-loop DBS algorithm using duration as the control signal. Benchtop...
Freezing of gait (FOG), a debilitating symptom Parkinson’s disease (PD), can be safely studied using the stepping in place (SIP) task. However, clinical, visual identification FOG during SIP is subjective and time consuming, automatic detection currently requires measuring center pressure on dual force plates. This study examines whether elicited 10 individuals with PD could reliably detected kinematic data measured from wearable inertial measurement unit sensors (IMUs). A general, logistic...
Emergent tremor in Parkinson's disease (PD) can occur during sustained postures or movement that is different from action tremor. Tremor contaminate the clinical rating of bradykinesia finger tapping. Currently, there no reliable way isolating emergent and measuring cardinal motor symptoms based on voluntary movements only.
Closed-loop deep brain stimulation is a novel form of therapy that has shown benefit in preliminary studies and may be clinically available the near future. Initial closed-loop have primarily focused on responding to sensed biomarkers with adjustments amplitude, which often perceptible study participants depending slew or "ramp" rate amplitude changes. These subjective responses ramping can result transient side effects, illustrating ramp unique safety parameter for neural systems. This...
Freezing of gait (FOG), a debilitating symptom Parkinson’s disease (PD), can be safely studied using the stepping in place (SIP) task. However, clinical, visual identification FOG during SIP is subjective and time consuming, automatic detection currently requires measuring center pressure on dual force plates. This study examines whether elicited 10 individuals with PD could reliably detected kinematic data measured from wearable inertial measurement unit sensors (IMUs). A general,...
Abstract Background The sequence effect is the progressive deterioration in speech, limb movement, and gait that leads to an inability communicate, manipulate objects or walk without freezing of gait. Many studies have demonstrated a lack improvement from dopaminergic medication, however few studied metric over time investigated open closed-loop deep brain stimulation people with PD. Objective To investigate whether worsens and/or improved on clinical (open-loop) (DBS). Methods Twenty-one PD...
Abstract Background Assessment of motor signs in Parkinson’s disease (PD) has required an in-person examination. However, 50% people with PD do not have access to a neurologist. Wearable sensors can provide remote measures some but require continuous data acquisition for several days. A major unmet need is reliable metrics all cardinal signs, including rigidity, from simple short active task that be performed remotely or the clinic. Objective Investigate whether thirty seconds repetitive...
Abstract Bradykinesia is the major cardinal motor sign of Parkinson’s disease (PD), but its neural underpinnings are unclear. Although impairment in PD has been linked to heightened synchrony within beta band (13-30 Hz) subthalamic nucleus (STN), bradykinesia appears be manifestation a network-level dysfunction including basal ganglia, cortex, and possibly cerebellum. The goal this study was examine whether changes over time following long-term STN deep brain stimulation (DBS) local dynamics...