A5069539116- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Eating Disorders and Behaviors
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Birth, Development, and Health
- Obsessive-Compulsive Spectrum Disorders
- Reproductive System and Pregnancy
- Obesity, Physical Activity, Diet
- Genetic Neurodegenerative Diseases
- Pregnancy and preeclampsia studies
- Ophthalmology and Eye Disorders
- Racial and Ethnic Identity Research
- Employee Welfare and Language Studies
- Obesity and Health Practices
- Urban, Neighborhood, and Segregation Studies
- Cardiac Health and Mental Health
- Psychological Well-being and Life Satisfaction
- Employment and Welfare Studies
- Health disparities and outcomes
- Thyroid Cancer Diagnosis and Treatment
- Stuttering Research and Treatment
- Nutritional Studies and Diet
- Microbial infections and disease research
University of California, Los Angeles
2018-2025
Stanford University
2019-2024
Fort Hays State University
2024
Kansas State University
2015-2016
Food insecurity is highly prevalent and linked to poorer diet worse metabolic outcomes. can be stressful, could elicit chronic psychological physiological stress. In this study, we tested whether stress used identify those at highest risk for measures from food insecurity. Specifically, hypothesized that cortisol (a marker of stress) perceived would amplify the link between hyperpalatable intake as well measures. a sample 624 Black White women aged 36–43 who participated in NHLBI Growth...
Freezing of gait (FOG) is a debilitating symptom Parkinson's disease (PD) that often refractory to medication. Pathological prolonged beta bursts within the subthalamic nucleus (STN) are associated with both worse impairment and freezing behavior in PD, which improved deep brain stimulation (DBS). The goal current study was investigate feasibility, safety, tolerability burst-driven adaptive DBS (aDBS) for FOG PD.
Mycoplasma infections, such as walking pneumonia or pelvic inflammatory diseases, are a major threat to public health. Despite their relatively small physical and genomic size, mycoplasmas known elicit strong host immune responses, generally inflammatory, while also being able evade the system. The mycoplasma membrane is composed of approximately two-thirds protein one-third lipid contains several lipoproteins that regulate responses. Herein, immunomodulatory effects reviewed. A better...
Bradykinesia is the major cardinal motor sign of Parkinson disease (PD), but its neural underpinnings are unclear. The goal this study was to examine whether changes in bradykinesia following long-term subthalamic nucleus (STN) deep brain stimulation (DBS) linked local STN beta (13-30 Hz) dynamics or a wider bilateral network dysfunction.
Pathologically prolonged bursts of neural activity in the 8-30 Hz frequency range Parkinson's disease have been measured using high power event detector thresholds.This study introduces a novel method for determining beta baseline based on spectral that overlapped simulated 1/f spectrum. We used resting state local field potentials from people with and signal to measure burst durations, demonstrate how tuning parameters (i.e., bandwidth center frequency) affect compare duration distributions...
A deep brain stimulation system capable of closed loop neuromodulation is a type bidirectional computer interface (dBCI), in which neural signals are recorded, decoded and then used as the input commands for at same site brain. The challenge assuring successful implementation dBCIs Parkinson's disease (PD) to discover decode stable, robust reliable inputs that can be tracked during stimulation, optimize neurostimulation patterns parameters (control policies) motor behaviors interface,...
Parkinson's disease (PD) is a systemic brain disorder where the cortical cholinergic network begins to degenerate early in process. Readily accessible, quantitative, and specific behavioral markers of are lacking. Although degeneration dopaminergic may be responsible for deficits cardinal motor signs, control gait complex process higher-order aspects gait, such as variability, influenced by cognitive processes attributed networks. We investigated whether swing time metric variability that...
Abstract Objective To investigate the progression of neural and motor features Parkinson's disease in a longitudinal study, after washout medication bilateral subthalamic nucleus deep brain stimulation (STN DBS). Methods Participants with clinically established underwent implantation DBS leads (18 participants, 13 male) within STN using standard functional frameless stereotactic technique multi‐pass microelectrode recording. Both were connected to an implanted investigative sensing...
Background: Resting state beta band (13-30 Hz) oscillations represent pathological neural activity in Parkinson's disease (PD). It is unknown how the peak frequency or dynamics of may change among fine, limb, and axial movements different phenotypes. This will be critical for development personalized closed loop deep brain stimulation (DBS) algorithms during states. Methods: Subthalamic (STN) local field potentials (LFPs) were recorded from a sensing neurostimulator (Activa® PC + S,...
Although it has been demonstrated that (a) body dissatisfaction and internalization of societal appearance standards contribute to disordered eating (b) leads decreased skin color satisfaction among Black women, not established whether contributes women or girls. The objective the present study is determine influence as a potential predictor for binge eating, its effect through image in girls during vulnerable developmental period adolescence. Using data from ten annual measurements 1213...
Low-income Black and Latinx individuals are disproportionately vulnerable to chronic stress metabolic disease. Evidence suggests that these populations engage in elevated levels of comfort eating (i.e., comforting food alleviate stress), which can harm diet quality. For this reason, many interventions discourage eating. However, if does indeed buffer stress, it may be a protective health behavior, particularly healthy foods (e.g., strawberries) as effectively traditional unhealthy brownies)....
UK national guidelines recommend the measurement of TSH receptor antibodies (TRAb) in certain clinical scenarios. A commercial third-generation TRAb autoantibody M22-biotin ELISA assay was introduced May 2008 our centre.To evaluate diagnostic performance a retrospective and subsequently prospective cohort centre.A review patients with thyroid disease followed by observational study consecutive newly found suppressed serum thyrotrophin (TSH).Medical records 200 disorders who had measured...
Abstract Background Young plasma infusions have emerged as a potential treatment for neurodegenerative disease, and convalescent therapy has been used safely in the management of viral pandemics. However, effect Parkinson's disease (PD) is unknown. Objectives The objective this study was to determine safety, tolerability, feasibility people with PD. Methods A total 15 clinically established PD, at least 1 cognitive complaint, on stable received unit young fresh frozen twice week 4 weeks....
The purpose of the current study was to test longitudinal association between disordered-eating symptoms (body dissatisfaction, drive for thinness, and bulimia) in adolescence (ages 12, 14, 16, 18, 19) adulthood (age 40) a sample 883 white Black women. We also investigated moderation by race. Adolescent at each time point significantly predicted Body Dissatisfaction Drive Thinness subscales both Bulimia adulthood; however, effect largely driven Although nonsignificant, among women, bulimia...
Abstract Background Although maternal stressor exposure has been associated with shorter telomere length (TL) in offspring, this literature is based largely on White samples. Furthermore, timing of stressors rarely examined. Here, we examined how occurring during adolescence, pregnancy, and across the lifespan related to child TL Black mothers. Method Mothers (112 Black; 110 White; M age = 39) their youngest offspring ( n 222; 8) were part a larger prospective cohort study, wherein mothers...
Early vascular ageing (EVA) contributes to elevated risk of cardiovascular disease (CVD), which disproportionately affects African American women. Incarceration, an event impacting Americans, may be a stressor contributing EVA in Further, the subjective perspective, commonly referred as appraisal, incarceration also important for health. We hypothesised that having family and/or friends incarcerated and appraising upsetting would associated with indices EVA.
Although emerging studies examine the inverse relationship between body satisfaction and disordered eating for Black women, it has not been established how racially salient aspects of may have implications behaviors longitudinal health outcomes.
Black individuals remain underrepresented in disordered eating research, despite evidence that both men and women present with behaviors. Culturally-informed theoretical frameworks suggest these behaviors may be linked to race-related sociocultural experiences, such as aspects of racial identity. While studies have focused on identity commitment, the association between attitudes toward one's remains underexplored. The study examines whether positive Blackness culture are associated eating.
Abstract Freezing of gait (FOG), a devastating symptom Parkinson’s disease (PD), can be refractory to current treatments such as medication and open-loop deep brain stimulation (olDBS). Recent evidence suggests that closed-loop DBS (clDBS), using beta local field potential power from the subthalamic nucleus (STN) control variable, improve tremor bradykinesia; however, no study has investigated use clDBS for treatment FOG. In this study, we provide preliminary was superior olDBS in reducing...
Abstract Background Resting state beta band (13 – 30 Hz) oscillations represent pathological neural activity in Parkinson’s disease (PD). It is unknown how the peak frequency or dynamics of may change among fine, limb and axial movements different phenotypes. This will be critical for development personalized closed loop deep brain stimulation (DBS) algorithms during states. Methods Subthalamic (STN) local field potentials (LFPs) were recorded from a sensing neurostimulator (Activa® PC+S,...