A5008451422- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
Stanford University
2023-2024
Freezing of gait (FOG) is a debilitating symptom Parkinson's disease (PD) that often refractory to medication. Pathological prolonged beta bursts within the subthalamic nucleus (STN) are associated with both worse impairment and freezing behavior in PD, which improved deep brain stimulation (DBS). The goal current study was investigate feasibility, safety, tolerability burst-driven adaptive DBS (aDBS) for FOG PD.
Background: The sequence effect is the progressive deterioration in speech, limb movement, and gait that leads to an inability communicate, manipulate objects, or walk without freezing of gait. Many studies have demonstrated a lack improvement from dopaminergic medication, however few studied metric over time investigated open-loop deep brain stimulation people with Parkinson’s disease (PD). Objective: To investigate whether worsens and/or improved on clinical (open-loop) (DBS). Methods:...
Over the past three decades, deep brain stimulation (DBS) for Parkinson’s disease (PD) has been applied in a continuous open loop fashion, unresponsive to changes given patient’s state or symptoms over course of day. Advances recent neurostimulator technology enable possibility closed adaptive DBS (aDBS) PD as treatment option near future which adjusts demand-based manner. Although aDBS offers great clinical potential motor symptoms, it also brings with need better understanding how...