A5030135536- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Lung Cancer Treatments and Mutations
- Neuroscience and Neural Engineering
- Lung Cancer Diagnosis and Treatment
- Neural dynamics and brain function
- Epilepsy research and treatment
- Mental Health Treatment and Access
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroscience and Neuropharmacology Research
- Anatomy and Medical Technology
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Economic and Financial Impacts of Cancer
- Advanced MRI Techniques and Applications
- Vagus Nerve Stimulation Research
- Advanced Radiotherapy Techniques
- Anesthesia and Pain Management
- Visual perception and processing mechanisms
- Esophageal Cancer Research and Treatment
- Medical Imaging Techniques and Applications
- Global Cancer Incidence and Screening
- Enhanced Recovery After Surgery
- Cancer Genomics and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
University of California, Los Angeles
2022
University of Southern California
2019-2022
Keck Hospital of USC
2021-2022
Neurological Surgery
2019-2020
State Street (United States)
2019
California Institute of Technology
2019
Interface (United States)
2019
Tulane University
2016
Abstract Objective. The ideal modality for generating sensation in sensorimotor brain computer interfaces (BCI) has not been determined. Here we report the feasibility of using a high-density ‘mini’-electrocorticography (mECoG) grid somatosensory BCI system. Approach. Thirteen subjects with intractable epilepsy underwent standard clinical implantation subdural electrodes purpose seizure localization. An additional mECoG was placed (Adtech, 8 by 8, 1.2 mm exposed, 3 center-to-center spacing)...
The objective was to compare overall survival (OS) between lobectomy and segmentectomy for patients with non-small cell lung cancers (NSCLCs) > 2 but ≤4 cm.The National Cancer Database queried identify treatment-naïve NSCLC tumors >2 cm. Eligible were diagnosed pT1 or T2 N0 M0 disease, underwent segmentectomy, received no adjuvant therapy. OS compared using the Kaplan-Meier method, Cox proportional-hazards model used prognostic factors death. Propensity score matching performed minimize...
Closed-loop brain-responsive neurostimulation via the RNS System is a treatment option for adults with medically refractory focal epilepsy. Using novel technique, 2 Systems (2 neurostimulators and 4 leads) were successfully implanted in single patient bilateral parietal epileptogenic zones. In patients multiple zones, this technique allows additional options. Implantation can be done successfully, without telemetry interference, using proper surgical planning neurostimulator...
Characterize the role of beta-band (13-30 Hz) in human hippocampus during execution voluntary movement.We recorded electrophysiological activity a reach task using stereotactic electroencephalography (SEEG). SEEG has previously been utilized to study theta band (3-8 conflict processing and spatial navigation, but most studies hippocampal movement have used noninvasive measures such as fMRI. We analyzed modulation beta Hz), which is known play prominent throughout motor system including...
Recently, efforts to produce artificial sensation through cortical stimulation of primary somatosensory cortex (S1) in humans have proven safe and reliable. Changes parameters like frequency amplitude been shown elicit different percepts, but without clearly defined psychometric profiles. This study investigates the functionally useful limits changes on percepts felt by three epilepsy patients with subdural electrocorticography (ECoG) grids. Subjects performing a hidden target task were...
Abstract BACKGROUND Three-dimensional fluoroscopy via the O-arm (Medtronic, Dublin, Ireland) has been validated for intraoperative confirmation of successful lead placement in stereotactic electrode implantation. However, its role registration and targeting not yet studied. After frame placement, many neurosurgeons obtain a computed tomography (CT) scan merge it with preoperative magnetic resonance imaging (MRI) to generate planning coordinates; potential disadvantages this practice include...
OBJECTIVE Stimulation of the primary somatosensory cortex (S1) has been successful in evoking artificial somatosensation both humans and animals, but much is unknown about optimal stimulation parameters needed to generate robust percepts somatosensation. In this study, authors investigated frequency as an adjustable parameter for a closed-loop brain-computer interface (BCI) system. METHODS Three epilepsy patients with subdural mini-electrocorticography grids over hand area S1 were asked...
The study objective was to determine what proportion of asymptomatic patients had resectable lung cancer detected through screening versus incidentally.We performed a retrospective who underwent resection for between January 2015 and December 2020. We then assessed whether with incidentally found cancers were eligible using the National Comprehensive Cancer Network, United States Preventive Services Task Force, Centers Medicare & Medicaid Services, American College Chest Physicians, Society,...
To investigate the relationship between planned drill approach angle and angular deviation of stereotactically placed intracranial electrode tips.
This qualitative study sought to uncover factors that influence decisions offer curative-intent surgery for patients with advanced-stage (stage IIIB/IV) non-small cell lung cancer.A trained interviewer conducted open-ended, semistructured telephone interviews cardiothoracic surgeons in the United States. Participants were recruited from Thoracic Surgery Outcomes Research Network, subsequent diversification through snowball sampling. Four hypothetical clinical scenarios presented, each...
In recent years, the collection of treatment modalities for patients with advanced-stage NSCLC has evolved at a considerable rate. EGFR tyrosine kinase inhibitors and immune checkpoint inhibitors, such as programmed death-ligand 1 have profoundly transformed therapy redefined what is possible stages III to IV NSCLC.1National Comprehensive Cancer NetworkNCCN clinical practice guidelines in oncology: non-small cell lung cancer.https://www.nccn.org/professionals/physician_gls/pdf/nscl.pdfGoogle...
The objective of this study was to compare overall survival (OS) between patients with pT1-2N1 versus pT3N0 NSCLC and various subtypes NSCLC.The National Cancer Database queried identify treatment-naive pathologic stage IIB primary NSCLC. Patients were included if they diagnosed or received definitive surgery within 4 months diagnosis. cohort subdivided by single multiple concurrent T3 descriptors single-T3 subtypes. 5-year OS compared using the Kaplan-Meier method, Cox proportional-hazards...
Signet ring cell (SRC) histology is considered a poor prognostic factor in various cancers. However, primary SRC lung adenocarcinoma rare and poorly understood.The National Cancer Database was queried to identify treatment-naïve patients who received lobectomy for or non-SRC pT1-2N0 <4 cm within four months of diagnosis. defined by ICD-O-3 code 8490, while codes 8140, 8141, 8143, 8147, 8255, 8260, 8310, 8481, 8560, 8570-8574. The Kaplan-Meier curve log-rank test used compare five-year OS...