A5002800136- Cancer-related Molecular Pathways
- Pharmacological Effects of Medicinal Plants
- Natural product bioactivities and synthesis
- Osteoarthritis Treatment and Mechanisms
- Ocular Surface and Contact Lens
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Retinoids in leukemia and cellular processes
- Advanced Breast Cancer Therapies
- RNA and protein synthesis mechanisms
- Phytochemicals and Medicinal Plants
- Circadian rhythm and melatonin
- Curcumin's Biomedical Applications
- Advanced Glycation End Products research
- NF-κB Signaling Pathways
- CRISPR and Genetic Engineering
- Medicinal Plant Extracts Effects
- Genomics, phytochemicals, and oxidative stress
- Ion Channels and Receptors
- Psoriasis: Treatment and Pathogenesis
- Olfactory and Sensory Function Studies
- Biochemical effects in animals
- Coffee research and impacts
- Exercise and Physiological Responses
- Retinal Diseases and Treatments
OmniActive Health Technologies (India)
2020-2025
Morristown Medical Center
2022
OmniActive Health Technologies (United States)
2021
Institute for Stem Cell Biology and Regenerative Medicine
2018-2019
Piramal (India)
2009-2015
University of Kansas Medical Center
2012
Juravinski Cancer Centre
2007
National Institute of Mental Health
2000-2002
National Institutes of Health
2000-2002
Albert Einstein College of Medicine
2000
Osteoarthritis (OA) is a chronic and debilitating disease of the knee joint. OA initiated by physical damage accumulated oxidative stress, followed an exaggerated inflammation leading to cartilage damage. Currently, no effective safe therapeutic option capable restoring articular tissue joint architecture available. We here report novel highly bioavailable formulation curcumin, labeled as Next Generation Ultrasol Curcumin (NGUC), which was 64.7 times more than natural 95% curcumin extract...
Insomnia is a major global health issue, highlighting the need for treatments that are both effective and safe. Valerian extract, traditional remedy sleep problems, offers potential therapeutic options. This research examined sleep-enhancing effects of VA (Valerian Pdr%2) in mice. The study evaluated quality by comparing impact extract against melatonin on brain activity, using electrocorticography (ECoG) to assess changes waves. For this purpose, utilized two experimental models BALB/c mice...
Vasomotor symptoms, such as hot flashes (HFs), commonly affect women during menopause, leading to a reduced quality of life. The current study evaluates the combined effect active components Asparagus racemosus (AR) and Trigonella foenum-graecum (TFG) in single oral formulation (IAT) for alleviating menopausal symptoms ovariectomized rats. Following bilateral ovariectomy, animals were randomly assigned nine groups: (1) Control, (2) Ovariectomy (OVX), (3) OVX+TA1 (TA: Combination Asparagus;...
The hepatitis E virus (HEV) is a small RNA and the cause of acute viral E. open reading frame 3 protein (pORF3) HEV appears to be pleiotropic regulatory that helps in establishment, propagation progression infection. However, global cellular effects this remain explored. In absence traditional vitro infection systems or efficient replicon systems, we made an adenovirus based ORF3 expression system study its on host cell gene expression. We infected Huh7 hepatoma cells with recombinant...
A significant group of patient with estrogen receptor (ER) α positive breast tumors fails to appreciably respond endocrine therapy. An increased understanding the molecular basis estrogen-mediated signal transduction and resultant gene expression may lead novel strategies for treating cancer. In this study, we sought identify dysregulated genes in related ERα status. Microarray analyses 31 tumor samples showed 108 differentially expressed (+) (-) primary tumors. Further lists indicated that...
The objective of the present study was to validate prognostic gene signature for estrogen receptor alpha-positive (ER03B1+) and lymph node (+) breast cancer improved selection patients adjuvant therapy. In our previous study, we identified a group seven genes (GATA3, NTN4, SLC7A8, ENPP1, MLPH, LAMB2, PLAT) that show elevated messenger RNA (mRNA) expression levels in ERα patient samples. values these were evaluated using data from three public sets (n = 395). Analysis cohort 195) showed high...
Dry eye syndrome (DES) is a chronic condition of the with insufficient production tears leading to inadequate lubrication eyes. Symptoms DES are associated discomfort and redness eye, blurred vision, tear film instability which leads damaged ocular surface. Inflammation oxidative stress play significant role in pathogenesis disease. In this study, protective effect different doses (100 or 200 mg/kg) novel multi-component oral formulation lutein/zeaxanthin, curcumin, vitamin D3 (LCD) was...
Exposure to light-emitting diode (LED) light is a primary cause of retinal damage, resulting in vision loss. Several plant-derived substances, such as lutein and quercetagetin (QCG), show promise supporting eye health. In this study, the impact lutein/zeaxanthin (L/Z, Lutemax 2020) QCG were evaluated individually together rat model LED-induced damage. A total 63 Wistar rats allocated into nine groups (n = 7). For 28 days, received L/Z (10 or 20 mg/kg BW), quercetin (QC, mixture different...
Despite advances in molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. It is rapidly invasive, metastatic tumor that resistant to standard therapies. The phosphatidylinositol-3-kinase/Akt and mTOR signaling pathways are frequently dysregulated cancer. Gemcitabine the mainstay treatment for P276 novel CDK inhibitor induces G(2)/M arrest inhibits growth vivo models. Here, we determined sensitizes cells gemcitabine-induced apoptosis, mechanism-mediated through...
Intracellular signals triggered by DNA breakage flow through proteins containing BRCT (BRCA1 C-terminal) domains. This family, comprising 23 conserved phosphopeptide-binding modules in man, is inaccessible to small-molecule chemical inhibitors. Here, we develop Bractoppin, a drug-like inhibitor of phosphopeptide recognition the human BRCA1 tandem (t)BRCT domain, which selectively inhibits substrate binding with nanomolar potency vitro. Structure-activity exploration suggests that Bractoppin...
Osteoarthritis (OA) is a musculoskeletal disorder mainly found in elderly individuals. Modern treatment of OA, like nonsteroidal anti-inflammatory drugs, corticosteroids, hyaluronic acid injections, etc., linked to long-term side effects. We evaluated the anti-osteoarthritic properties novel joint health formula (JHF) containing Bisdemethoxycurcumin enriched curcumin, 3-O-Acetyl-11-keto-beta-Boswellic acid-enriched Boswellia, and Ashwagandha monosodium iodoacetate (MIA)-induced knee OA rats....
Tumors of the head and neck present aggressive pathological behavior in patients due to high expression CDK/CCND1 proteins. P276-00, a novel CDK inhibitor currently being tested clinic, inhibits growth several cancers vitro vivo. The pre clinical activity P276-00 cancer its potential mechanisms action at molecular level are focus current studies.We have investigated anti-cancer tumors Candidate gene profiling cell based proteomic approaches were taken understand pathways affected by...
Several studies have characterized drug-induced toxicity in liver and kidney. However, the majority of these been performed with 'individual' organs isolation. Separately, little is known about role whole blood as a surrogate tissue toxicity. Accordingly, we investigated 'concurrent' response liver, kidney during toxic assault. Rats were acutely treated therapeutics (acetaminophen, rosiglitazone, fluconazole, isoniazid, cyclophosphamide, amphotericin B, gentamicin cisplatin) reported for...
Retinal damage associated with loss of photoreceptors is a hallmark eye diseases such as age‐related macular degeneration (AMD) and diabetic retinopathy. Potent nutritional antioxidants were previously shown to abate the degenerative process in AMD. β ‐Cryptoxanthin (BCX) an essential dietary carotenoid antioxidant, anti‐inflammatory, provitamin A activity. It potential candidate for developing intervention strategies delay development/progression In current study, effect novel, highly...
Lutein (L) and zeaxanthin (Z) are carotenoids that found in the macula of human eye known to improve visual functions. However, poor bioavailability supplemental L Z poses a challenge achieving significant benefits after consumption. We developed novel patented formulation (Ocusorb®) demonstrated improved pharmacokinetic clinical study.Ninety adult volunteers were recruited this randomized, double-blind, parallel, comparative study. Volunteers randomly assigned receive single dose 10 mg...