Tendon healing is a complex coordinated series of events resulting in protracted recovery, limited regeneration, and scar formation. Mesenchymal stem cell (MSC) therapy has shown promise as new technology to enhance soft tissue bone healing. A challenge with MSC involves the ability consistently control inflammatory response subsequent Previous studies suggest that preconditioning MSCs cytokines, such IFN-γ, TNF-α, IL-1β may accelerate cutaneous wound closure. The objective this study was...

Background: Platelet-rich plasma therapy has the potential to promote peripheral nerve regeneration through autologous supply of growth factors. Therefore, this study aimed compare effects platelet-rich injections with corticosteroid in treatment carpal tunnel syndrome.Methods: In total, 40 patients mild syndrome were equally divided into two groups. Nerve conduction studies carried out, and Boston Carpal Tunnel Questionnaire was administered both groups before treatment. One group received...

To compare the levels of MMP-13 and TNF-α in late stage osteoarthritis, define their predominant pathways investigate correlation with McMaster Universities Arthritis Index scores.A total 42 patients (mean age 64 ± 8.8) grade 3 4 knee osteoarthritis according to Kellegren- Lawrence criteria who were scheduled for arthroplasty enrolled study. TNF-alpha measured preoperatively from venous blood samples intraoperatively synovial fluid via ELISA. Preoperative 1 month postoperative functions...

A normal healing response after ligament and tendon rupture results in scar formation an inferior tissue that fails to emulate its original structure, composition, function. More regenerative (closer the original) can be obtained through early suppression of inflammatory cells associated cytokines. Examination immune mediated mesenchymal stem/stromal (MSCs) during indicates MSCs reprogram macrophages from a pro-inflammatory M1 phenotype anti-inflammatory M2 phenotype. Based on these studies...

We investigated the anti-inflammatory and immunomodulatory effect of simvastatin on articular cartilage via inhibition matrix metalloproteinase-3 (MMP-3), a matrix-degrading enzyme, in mechanically induced experimental osteoarthritis (OA) animal model.Twenty-seven albino Wistar rats were divided three groups equal number. Unphysiologic loading was simulated by transecting anterior cruciate ligaments right knees 18 consisting 1 2. Nine animals group 2 received orally administered 20 mg/kg per...

The aim of this study was to compare serum and synovial fluid levels matrix metalloproteinase-13 (MMP-13) tumor necrosis factor-alpha (TNF-α) in 2 stages osteoarthritis, investigate their correlation with Western Ontario McMaster Universities Arthritis Index (WOMAC) scores.Forty-two patients (mean age: 64±8.8 years) grade 3 4 knee osteoarthritis according Kellgren-Lawrence criteria were enrolled the underwent total arthroplasty. TNF-α MMP-13 measured preoperatively from venous blood samples...

This study aims to evaluate the clinical outcomes of children with spastic type cerebral palsy (CP) treated botulinum toxin A (BoNT-A) injection for lower limb contracture and influence age, gender, functional level degree initial on treatment outcomes.Clinical records at pre-BoNT-A post-BoNT-A injections 153 sessions a total 118 consecutive (67 boys, 51 girls; mean age 5.9±2.6 years; range, 2.5-16 years) were retrospectively evaluated. Degrees pre- post-injection Post-injection supplemental...

Simultaneous bilateral total knee arthroplasty (TKA) with prolonged tourniquet time has the potential to trigger ischemia-reperfusion injury, which can adversely affect function. Studies suggest that magnitude of injury is less if it occurs following an ischemic event takes place in another part body, known as preconditioning (IPC). The purpose this study was investigate impact oxidative stress on muscle and function elucidate IPC effect attenuate metabolites prevent poor functional outcomes...

Objectives . Cage design and material properties play a crucial role in the long-term results, since interbody fusions using intervertebral cages have become one of basic procedures spinal surgery. Our aim is to novel Apatite-Wollastonite fusion cage evaluate its biomechanical behavior silico segmental model. Materials Methods Mechanical for bioceramic were obtained by fitting finite element results experimental compression prototype. The prototype was made from hydroxyapatite,...

Studies report 19-33% postoperative moderate-severe pain and dissatisfaction in uncomplicated total knee arthroplasty (TKA), even after 1 year. High rates of undiagnosed depression anxiety may have a strong impact on these unfavourable outcomes. Here we aimed to investigate the efficacy alprazolam analgesic use functions.Seventy-six patients with mean age 65 ± 9.3 years (range 46-80) diagnosed mild-moderate or according Hamilton scale (HAS) Beck Depression Inventory (BDI) that underwent TKA...

Introduction: Brucellosis is a zoonotic infectious disease that remains endemic in developing countries. The purpose of this study to emphasize the need for considering brucellosis as diagnosis, since has high risk complications among young patients when not treated appropriately. Methodology: A total 88 cases with blood cultures were positive pathogen evaluated retrospectively study. Results: included 33 males (37.5%) and 55 females (62.5%) median age 8.9 years (range: 5-14 years). 43.1%...

The paper discusses the importance of Real-Time Data Analysis (RTDA) with innovative fluid business models for tourism industry. study uses a conceptual approach to identify and their relationships RTDA based on problematisation crucial need holistic, macro understanding ecosystem rather than framing issue from micro point view. highlights that current digital era makes it no longer possible stakeholders use static collect, store, analyse data make decisions accordingly. Innovative should be...

Chondromyxoid fibromas (CMF) are benign cartilaginous bone tumors which found most frequently in the metaphyses of long bones. They comprise less than 1% primary neoplasms. We report an interesting incidental case a 43-year-old woman with CMF left pubic ramus, presenting complaints gradual onset groin pain over period 2 years. According to radiological examination, malign chondroid tumor was excluded, and histopathological examination confirmed diagnosis CMF. The patient underwent aggressive...

The aim of this study was to compare the performance multimodal intraoperative neurophysiological monitoring (MIONM) in children below and over 6 years age.43 children, diagnosed with spinal pathologies were divided into two cohorts according their age enrolled study. Those under consisted group A, whereas those between 11 B. All patients underwent surgical procedures diagnosis. A standard anesthesia protocol given both groups. Baseline somatosensory evoked potentials (SSEPs) transcranial...

Although, trauma, foot deformity (pes planovalgus), systemic diseases such as diabetes mellitus and lupus, drugs (steroids, antineoplastic) excessive alcohol consumption have all been accused in the etiology of avascular necrosis tarsal bones, spontaneous navicular bone, especially adults, is a rare entity.In this article, we report 50-year-old female patient with bilateral, bone related severe talonavicular arthrosis.Clinical radiological findings were concordant Müller-Weiss disease, which...

We report the surgical treatment course of a 4-year-old girl with congenital scoliosis, diastematomyelia and double adjacent hemivertebrae. She had lumbar curve an apparent pelvic obliquity. Simultaneous excision segmented sequential hemivertebra at L3-L4 level fusion short-segment instrumentation was performed via posterior approach. Intraoperative radiographs revealed satisfactory correction 0° Following hemivertebrae, three nerve roots were placed in one intervertebral foramen...

The purpose of this study was to evaluate symptomatic bone metastases from urological malignancies and the efficacy surgical treatment in achieving local tumor control.This a retrospective observational patients diagnosed with who died their diseases between 2002 2013. Data on clinicopathology, number sites metastasis, time first subsequent survival after nature metastasis (blastic, mixed, lytic), type reconstruction, systemic affections, visceral organ for 70 deceased (55 male, 15 female)...