A5060288466- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Free Radicals and Antioxidants
- Synthesis and Biological Evaluation
- Hypothalamic control of reproductive hormones
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Receptor Mechanisms and Signaling
- RNA Research and Splicing
- Neuropeptides and Animal Physiology
- Immune Cell Function and Interaction
- RNA regulation and disease
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
Rutgers Sexual and Reproductive Health and Rights
2025
Rutgers, The State University of New Jersey
2020-2024
Johnson University
2020
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferative IEL (γδHYP) phenotype also upregulate expression ectonucleotidase CD39, marker regulatory cells. Enhanced TCR and IL-15 signaling correlates with progression from naive-like CD39neg to more mature, tissue-adapted CD39hi population. found TCRγδ activation drives CD122-mediated CD39 upregulation...
Abstract Triple-negative breast cancer (TNBC) is a highly metastatic and deadly disease. TNBC tumors lack estrogen receptor (ERα), progesterone (PR), HER2 (ErbB2) exhibit increased glutamine metabolism, requirement for tumor growth. The G protein-coupled kisspeptin (KISS1R) expressed in patient promotes malignant transformation of epithelial cells. This study found that patients displayed elevated plasma levels compared with healthy subjects. It also provides the first evidence addition to...
Histone acetyltransferases KAT2A and KAT2B are paralogs highly expressed in the intestinal epithelium, but their functions not well understood. In this study, double knockout of murine Kat2 genes epithelium was lethal, resulting robust activation interferon signaling interferon-associated phenotypes including loss stem cells. Use pharmacological agents sterile organoid cultures indicated a cell-intrinsic double-stranded RNA trigger for signaling. Acetyl-proteomics sequencing...
ABSTRACT Histone acetyltransferases KAT2A and KAT2B are paralogs highly expressed in the intestinal epithelium, but their functions not well understood. In this study, double knockout of murine Kat2 genes epithelium was lethal, resulting robust activation interferon signaling interferon-associated phenotypes including loss stem cells. Use pharmacological agents sterile organoid cultures indicated a cell-intrinsic double-stranded RNA trigger for signaling. Acetyl-proteomics dsRIP-seq were...