As the most promising candidates for implementation of in-sensor computing, retinomorphic vision sensors can constitute built-in neural networks and directly implement multiply-and-accumulation operations using responsivities as weights. However, existing mainly use a sustained gate bias to maintain responsivity due its volatile nature. Here, we propose an ion-induced localized-field strategy develop with nonvolatile tunable in both positive negative regimes construct broadband...

Abstract Photoelectric synaptic devices with optical sensing capability are of great importance in simulating human vision systems. Especially realizing all‐in‐one neuristor on silicon based new materials and principles is being pursued. 2D van der Waals (vdW) have the unique advantage arbitrary stacking demand. Herein, a full‐vdW two‐terminal ferroelectric α ‐In 2 Se 3 /SnSe p–n heterojunction proposed to construct an optoelectronic simulate visual functions. Implementation these...

Abstract Bioinspired neuromorphic machine vision system (NMVS) that integrates retinomorphic sensing and computing into one monolithic is regarded as the most promising architecture for visual perception. However, large intensity range of natural lights complex illumination conditions in actual scenarios always require NMVS to dynamically adjust its sensitivity according environmental conditions, just like adaptation function human retina. Although some opto‐sensors with scotopic or photopic...

Abstract Artificial synapses and neurons are crucial milestones for neuromorphic computing hardware, memristors with resistive threshold switching characteristics regarded as the most promising candidates construction of hardware neural networks. However, can only operate in one mode, that is, or switching, distinct required to construct fully memristive making it more complex fabrication integration hardware. Herein, we propose a flexible dual‐mode memristor array based on core–shell CsPbBr...

Comprehensive Summary Alcohols as among the most widely occurring organic compounds known, deoxygenative transformations of free alcohols partners in radical addition reactions remain formidable challenges with great opportunities to achieve new and useful transformations. Herein, we report a protocol via C—O bond cleavage C—C bond‐forming reaction trifluoromethyl alkenes assisted by titanium reagents strategy, enabling divergent synthesis for functional‐group‐rich organofluorinated high...

Summary Panax notoginseng saponin (PNS) is the most important physical and chemical index of panax notoginseng. In order to detect PNS rapidly non‐destructively, 160 hyperspectral images rhizome main root were acquired by using a visible‐near infrared image acquisition system (400–1000 nm), original spectrum extracted from images. The signal‐to‐noise ratio was improved savitzky‐golay mixed multiplication scatter correction (SG‐MSC) pretreatment. Feature wavelengths competitive adaptive...

Abstract Illegal merchants adulterate the powder of panax notoginseng rhizome and main root with fibrous root, which reduces efficacy hygiene powder. To detect adulteration nondestructively rapidly, in this study, hyperspectral images 80 samples adulterated (AR & AM) were collected by using a image acquisition system (400–1000 nm). Then, Savitzky–Golay standard normalized variable (SG‐SNV) used to preprocess spectrum improve signal‐to‐noise ratio data. Next, competitive adaptive...

Abstract In order to explore the drying characteristics of Panax notoginseng taproot (PNT) and realize dynamic monitoring moisture content in segmented process microwave vacuum combined with hot air, PNT was conducted experimental study under different convert contents wet basis (20, 30, 40 g•g −1 ), upper‐temperature limits (45, 50, 55°C), power densities (0.50, 0.75, 1.00, 1.50 W•g ) chamber pressures (1, 3, 5, 10 kPa). The changes ratio rate conditions were studied, a snake...

The study was to investigate the prevention effects and possible mechanism of Yu Ping Feng San fractioned polysaccharide (YPF-P) on CCl(4)-induced liver fibrosis in rats.YPF-P prepared from root Astragalus membranaceus, rhizome Atractylodes macrocephaia Raidix saposhnikoviae, compared with membranaceus (AP). Hepatic induced by subcutaneous injection carbon tetrachloride twice weekly for 12 weeks Sprague-Dawley rats. YPF-P, AP colchicine were administered intragastrically daily...

To realize the non-destructive identification of Panax notoginseng powder in different parts, this research proposes a method based on electronic nose and time-domain feature extraction. First, technology combined with statistical analysis was used to collect extract nine characteristics response information whole root powder, tap rhizome fibrous including data at 110 s, mean value between 101–120 maximum value, minimum integral differential skewness factor, kurtosis standard deviation 0–120...

Abstract An efficient preparation for arylethynyl sulfides 1 and bis(arylethynyl) 2 has been accomplished through a one‐pot, three‐step strategy that starts from arylethanonyl bis(arylethanonyl) sulfides, respectively, without the use of various terminal arylacetylenes as substrates. When lithium hexamethyldisilazane (LHMDS), ClP(O)(OEt) , LHMDS were sequentially added to tetrahydrofuran solution different substrates [arylethanonyl or sulfides], obtained in moderate good yields. The reaction...

The existing classification methods for Panax notoginseng taproots suffer from low accuracy, efficiency, and poor stability. In this study, a model based on image feature fusion is established taproots. images of collected in the experiment are preprocessed by Gaussian filtering, binarization, morphological methods. Then, total 40 features extracted, including size shape features, HSV RGB color texture features. Through BP neural network, extreme learning machine (ELM), support vector (SVM)...

Multidrug resistance is a serious problem and common cause of cancer treatment failure, leading to patient death. Although numerous reversal inhibitors have been evaluated in preclinical or clinical trials, efficient low-toxicity agents not identified. In this study, series novel quinoline compound derivatives from NSC23925 were designed inhibit P-glycoprotein (P-gp). Among them, YS-7a showed stronger inhibitory effect against P-gp than verapamil, as positive control, when co-incubated with...

Abstract Cracks in walnuts during processing and storage can adversely affect their quality cause economic losses. To achieve efficient identification of cracked walnuts, this study proposed a method walnut crack based on acoustic vibration feature fusion. First, the sound signals intact were collected using an signal acquisition system, 44 time‐domain features, 13 frequency‐domain 768 Mel spectrogram features (the number pixel frequencies corresponding to gray‐scale values R, G, B channels)...

Based on the positive effects of COX-2 inhibitors depressive symptoms and desirable physicochemical biological properties morpholine group, a series novel 2-(2-arylmorpholino)ethyl esters ibuprofen hydrochlorides were designed, synthesized, tested for their inhibitory serotonin reuptake activities in vitro. The structure-activity relationships as dual determined discussed detail. assays indicated that five compounds possess good selectivity (selectivity index COX-1/COX-2 42.8-158.1)....

A number of novel 2-(2-arylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochlorides were synthesized and tested for their cyclooxygenase (COX-1 COX-2) inhibition properties in vitro. Many these compounds exhibited moderate to good selective COX-2 inhibition, subtle structural changes the substituents on side chain ester moiety altered inhibitory significantly. 2-[2-(4-Butoxyphenyl)morpholino-4-yl]ethyl hydrochloride (1f), showed activity (Selective index...

Ten novel 3-(2-(3-methyl-5-substituted-phenyl-4,5-dihydropyrazol-1-yl)-2-oxo-ethoxy)-2-substituted-phenyl- 4H-chromen-4-one derivatives were synthesized and characterized by 1H NMR 13 C NMR. All of the compounds have been screened for their anticancer activity. The bioassay tests show that compound 6af exhibited potentially high activity against human gastric cancer cell SGC-7901 with IC50 value 4.01±0.97 μg/mL. Also, title assayed telomerase inhibition. results 6cf, can strongly inhibit...