A5015076210- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Trace Elements in Health
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Organ Transplantation Techniques and Outcomes
- Diabetes and associated disorders
- Nutritional Studies and Diet
- Blood transfusion and management
- Endoplasmic Reticulum Stress and Disease
- Colorectal Cancer Screening and Detection
- Blood donation and transfusion practices
- Drug-Induced Hepatotoxicity and Protection
- Pancreatitis Pathology and Treatment
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- RNA regulation and disease
- Cholesterol and Lipid Metabolism
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Eosinophilic Esophagitis
- Sulfur Compounds in Biology
Oregon Medical Research Center
2024
Johns Hopkins University
2019-2022
Johns Hopkins Medicine
2020-2022
Otto-von-Guericke University Magdeburg
2018-2021
University Hospital Magdeburg
2018-2020
Essen University Hospital
2017
The University of Texas at San Antonio
1971
United States Department of Veterans Affairs
1949
Abstract Wilson disease (WD) is caused by inactivation of the copper transporter Atp7b and overload in tissues. Mice with deleted either globally (systemic inactivation) or only hepatocyte recapitulate various aspects human disease. However, their phenotypes vary, neither common response to nor factors contributing variability are well defined. Using metabolic, histologic, proteome analyses three -deficient mouse strains, we show that global enhances specifically modifies Cu overload. The...
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic nowadays with currently no approved therapies for disease. The plays a pivotal role in lipid and glucose metabolism. interactions molecular mechanisms on gut example influences development still needs to be understood. Bile acids (BA) have been shown impact metabolic homeostasis insulin sensitivity. Here, we comment study analyzing BA profiles NAFLD patients addressing novel pathways involved progression.
<b><i>Background:</i></b> The definition of acute liver failure (ALF) usually implies no previous injury. Though, some patients admitted to transplantation centers with the diagnosis ALF are obese or have diabetes. Elevated enzymes were not recorded previously, and signs cirrhosis prior decompensation function ever present. Still, these differ from “typical” ALF-patient. <b><i>Goals:</i></b> In this study, we aimed confirm...
Wilson disease (WD) is a metabolic disorder caused by inactivation of the copper-transporting ATPase 2 (ATP7B) and copper (Cu) overload in tissues. Excess Cu causes oxidative stress pathologic changes with poorly understood mechanistic connections. In Atp7b-/- mice established liver disease, activates stress-sensitive transcription factor Nrf2 (nuclear erythroid-derived 2-like 2). targets, especially sulfotransferase 1e1 (Sult1e1), are strongly induced cause elevation sulfated sterols,...
<b><i>Background and Aim:</i></b> Nonalcoholic fatty liver disease (NAFLD) affects about 25% of the global population, with no reliable noninvasive tests to diagnose nonalcoholic steatohepatitis (NASH) differentiate between NASH (NAFL) (steatosis alone). It is unclear if NAFL differ in cardiovascular risk for patients. Here, we compared obese NAFLD patients a healthy cohort test whether cholesterol compounds could represent potential markers estimate associated risks....
Summary A child with mild hemolytic disease due to anti‐Di b was born a Mexican woman. The diagnosis made antisera which identified high frequency antigens. An earlier case of maternal sensitization is also noted.
// Aline Gottlieb 1 , Kristina Althoff Laura Grunewald 2 Theresa Thor Andrea Odersky Marc Schulte Hedwig E. Deubzer 2, 3 Lukas Heukamp 4 Angelika Eggert 5, 6, 7 Alexander Schramm Johannes H. 6 Annette Künkele Department of Pediatric Oncology, University Hospital Essen, 45122 Germany Hematology and SCT, Charité, 13353 Berlin, Junior Neuroblastoma Research Group, Experimental Clinical Center the Max-Delbrück for Molecular Medicine (MDC), 13125 Institute Pathology, Cologne, 50924 5 German...
(1949). Syphilitic Stenosis of the Coronary Ostia Diagnosed During Life. Postgraduate Medicine: Vol. 6, No. 5, pp. 372-378.
Budd-Chiari syndrome is a rare but critical condition that can progress to liver failure and death. For severe cases, orthotopic transplant remains the only curative option. The present study aimed identify predictive parameters assess outcomes of transplant.Medical records 33 individuals with who received were retrospectively assessed. Twenty-seven eligible patients identified grouped by outcome (survived/deceased) after for syndrome. Demographic, clinical, serum taken at time diagnosis...
Question Non-alcoholic fatty liver disease (NAFLD) affects about 25 % of the global population, with no reliable non-invasive tests to diagnose non-alcoholic steatohepatitis (NASH) and differ between NASH NAFL (steatosis alone). It is unclear if in cardiovascular risk for patients. Here, we compared obese NAFLD patients a healthy cohort, test, whether cholesterol compounds could represent potential markers estimate associated risks.
Background and aims Wilson disease (WnD) is caused by inactivation of the copper (Cu) transporter ATP7B Cu accumulation in tissues. WnD manifestations vary significantly, modifying factors are not fully understood. Liver steatosis often, but always, observed WnD. To identify influencing development WnD, we compared mice with a diet-induced Atp7b-/- without high calorie supplementation diet.