Intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) agents have become the most prevalent intraocular procedure as they represent major therapeutic modality for retinal conditions such age-related macular degeneration (AMD) and diabetic retinopathy. Effective therapy requires adherence to a schedule iterative IVI well routine clinic appointments. The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in reduction attendance at scheduled visits...

The aim of this study is to analyze mortality in patients treated with bevacizumab for wet AMD.We conducted a retrospective case-control between who received intravitreal injections as the sole treatment exudative AMD September 2008 and October 2014 (n = 5385) age gender matched controls 10,756). All individuals included were reviewed sociodemographic data comorbidities. Survival analysis was performed using adjusted Cox regression, relevant variables.During follow-up (maximum: 73 months),...

Bevacizumab and ranibizumab are routinely used to treat diabetic macular edema (DME). We aim evaluate the usefulness of switching therapy following bevacizumab treatment failure in eyes with DME.We performed a retrospective analysis consecutive group patients DME who received injections injections. The were delivered pro re nata protocol every 4-6 weeks. data collected included demographics, systemic ophthalmic findings, as well central subfield thickness according spectral-domain OCT.Eight...

Purpose: To assess the clinical relevance of routine preoperative spectral-domain optical coherence tomography (SD-OCT) for identifying macular pathologies in patients scheduled cataract surgery. Setting: Shaare-Zedek Medical Center, Jerusalem, Israel. Design: Retrospective case series. Methods: Consecutive patients, 50 years age and older, standard extraction surgery were enrolled from November 2017 to January 2018. All study underwent SD-OCT scanning before The scans reviewed by a retinal...

To analyse the mortality associated with intravitreal injections of bevacizumab for age-related macular degeneration (AMD) in patients previously diagnosed stroke or transient ischaemic attack (TIA).We reviewed bevacizumab-treated AMD a diagnosis TIA prior to their first injection (n = 948). Those patients, naïve any anti-vascular endothelial growth factor (anti-VEGF) at time stroke/TIA, were then compared age- and gender-matched who had stroke/TIA same never been exposed anti-VEGF. Survival...

To compare the visual and anatomic outcomes of macular edema secondary to retinal vein occlusion after switching from bevacizumab ranibizumab, aflibercept, or dexamethasone implant.Fifteen eyes were switched 12 10 dexamethasone. At 3, 6, 9, months, outcome measures acuity (VA) central thickness (CMT).One year switch, CMT decreased 430.11 ± 91.21 291.86 43.87 μm (p < 0.001). VA increased in 59.5% eyes. No difference between groups was found those at 1 year, but number injections varied: 3.30...

Background: Calcium is considered an important factor in the development of both osteoporosis and cataract. This study evaluated association between cataracts. Objective: To evaluate prevalence among patients undergoing cataract surgery, two. Patients methods: was a retrospective observational case-control study, conducted Central District Clalit Health Services (a district largest health maintenance organization Israel). All members older than 50 years who underwent surgery from 2000 to...

To characterize angioid streaks (AS) with en face optical coherence tomography (OCT).Case report of a patient myopia presenting choroidal neovascularization secondary to AS. Swept-source OCT ability image the was compared spectral-domain and swept-source B-scans as well color red-free pictures. A 48-year-old man presented sudden central visual loss. Choroidal AS diagnosed intraocular anti-vascular endothelial growth factor given clinical features improvement.Angioid were visualized less dark...

To evaluate the prevalence of epilepsy among patients undergoing cataract surgery.A retrospective observational case control study.We calculated all older than 50 years who underwent surgery (years 2000-2007, n = 12,984) in a district largest health maintenance organization Israel (the Central District Clalit Health Services) and 25,968 age gender matched controls. The database was screened for by integrating clinical ancillary work-up as well drug regimen. use anti-epileptic drugs (AEDs)...

To describe the advantages of en face view with swept-source optical coherence tomography in assessing morphologic features retinal arterial macroaneurysms, their consequences on adjacent retina, planning laser treatment, and evaluating its effects.Three eyes were treated for macroaneurysms followed by 2014-2015. En images retina choroid obtained EnView, a program.Retinal have typical appearance. allows delineation macroaneurysm wall, thrombotic components within dilation, lumen measurement....

We present a case of choroidal nevus, complicated by neovascular membrane (CNV) that was detected OCT angiography. Choroidal nevi are relatively common intraocular tumors. The presence subretinal and intraretinal fluids can indicate CNV has occurred as complication, warranting prompt management. However, also documented in without CNV. angiography may be great help determining whether those associated or not with CNV, therefore guiding therapy.

Purpose: To evaluate the outcome of second-line intravitreal ranibizumab treatment in eyes with diabetic macular edema having persistent following initial therapy bevacizumab. Methods: Diabetic treated bevacizumab failure Israel was a retrospective, multi-center study. Consecutive at least three previous injections prior to ranibizumab, three-monthly and 12 months follow-up were included. Data collected included demographics, ocular findings, diabetes control, details injections, visual...

Purpose To compare enhanced depth imaging in swept-source optical coherence tomography and non–enhanced their ability to capture choroidal scleral details. Methods Averaged foveal B-Scans were obtained from 40 eyes of 20 healthy volunteers by with without imaging. Visibility contrast vascular details within the choroid, choroidoscleral junction, sclera evaluated masked readers using an ordinal scoring scale. Outcomes analyzed Wilcoxon signed rank-sum test. Results ( Z = 5.94, p &lt; .001),...

Type-1 Gaucher disease (GD1) is considered to be non- neuronopathic however recent evidence of neurological involvement continues accumulate. There limited retinal abnormalities in GD1. The purpose this study was evaluate the findings patients with Thirty GD1 individuals and 30 healthy volunteers between ages 40–75 years were prospectively enrolled. Macular optic nerve optical coherence tomography (OCT) scans both eyes each patient performed thickness maps compared groups. Patients a known...

&lt;b&gt;&lt;i&gt;Purpose:&lt;/i&gt;&lt;/b&gt; Conflicting data were reported with respect to the retinal phenotype of mice dual perturbation CCL2 and CX3CR1 genes. We report generation a reverse CCR2/CX3CL1 gene deficiency as suggested model for age-related macular degeneration (AMD). &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Crossing single-deficient generated DKO mice. compared age-matched C57BL6J Evaluation included color fundus photographs, electroretinography (ERG), histology...