A5071998319- Reproductive Biology and Fertility
- Animal Genetics and Reproduction
- Genomic variations and chromosomal abnormalities
- DNA Repair Mechanisms
- Tissue Engineering and Regenerative Medicine
- Chromosomal and Genetic Variations
- Prenatal Screening and Diagnostics
- Microtubule and mitosis dynamics
- Photosynthetic Processes and Mechanisms
- Sperm and Testicular Function
- Genetics, Aging, and Longevity in Model Organisms
Utrecht University
2022-2024
University Medical Center Utrecht
2023
Heidelberg University
2023
University Hospital Heidelberg
2023
Royal Netherlands Academy of Arts and Sciences
2023
Error-free chromosome segregation in mitosis and meiosis relies on the assembly of a microtubule-based spindle that interacts with kinetochores to guide chromosomes cell equator before anaphase. Microtubules sprout from nucleation sites such as centrosomes, but can also promote microtubule formation. It is unclear, however, how kinetochore-derived microtubules are generated what their role segregation. Here, we show transient outer-kinetochore meshwork known fibrous corona serves an...
During normal zygotic division, two haploid parental genomes replicate, unite and segregate into biparental diploid blastomeres.
Abstract Study question How does the Fibrous Corona (FC) behave in human and bovine oocyte meiosis what is its function chromosome segregation during I? Summary answer In oocytes, FC shows extreme plasticity expanding beyond centromeric region of chromosomes. Pharmacological inhibition FC’s expansion induces mis-segregation. What known already Embryonic aneuploidy meiotic origin one major causes implantation failure early pregnancy loss. Erroneous microtubule (MT)-kinetochore attachments are...