A5101745142- Gut microbiota and health
- Probiotics and Fermented Foods
- Digestive system and related health
- Gastrointestinal motility and disorders
- Infant Nutrition and Health
- Diet and metabolism studies
- Microbial Metabolites in Food Biotechnology
- Infant Health and Development
- Listeria monocytogenes in Food Safety
- Food composition and properties
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Clostridium difficile and Clostridium perfringens research
- GABA and Rice Research
- Colorectal Cancer Screening and Detection
- Metabolomics and Mass Spectrometry Studies
- Neurogenesis and neuroplasticity mechanisms
- Agriculture, Soil, Plant Science
- Neonatal and fetal brain pathology
- Organizational Management and Leadership
- Vasculitis and related conditions
Göteborgs Stads
2020
University of Gothenburg
1979-2020
University of Copenhagen
2003-2016
Technical University of Denmark
2010-2015
Food Research Institute
2009-2015
Aarhus University Hospital
2007
Lundbeck (Denmark)
2007
Bispebjerg Hospital
2003
Centrallasarettet Växjö
1955
Fecal samples were obtained from a cohort of 330 healthy Danish infants at 9, 18, and 36 months after birth, enabling characterization interbacterial relationships by use quantitative PCR targeting 31 selected bacterial 16S rRNA gene targets representing different phylogenetic levels. Nutritional parameters measures growth body composition determined investigated in relation to the observed development microbiota composition. We found that significant changes gut occurred, particularly age 9...
Evidence suggests that early life infections, presence of older siblings and furred pets in the household affect risk developing allergic diseases through altered microbial exposure. Recently, low gut diversity during infancy has also been linked with later development allergies. We investigated whether siblings, infections affected communities at 9 18 months age these differences were associated cumulative prevalence atopic symptoms eczema asthmatic bronchitis 3 years age. Bacterial...
Our study was part of the large European project ISAFRUIT aiming to reveal biological explanations for epidemiologically well-established health effects fruits. The objective identify apple and product consumption on composition cecal microbial community in rats, as well a number parameters, which may be influenced by changed microbiota.Principal Component Analysis (PCA) microbiota profiles obtained PCR-DGGE targeting bacterial 16S rRNA genes showed an effect whole apples long-term feeding...
Alterations in the human gut microbiota caused, for example, by diet, functional foods, antibiotics, or occurring as a function of age are now known to be relevance host health. Therefore, there is strong need methods detect such alterations rapid and comprehensive manner. In present study, we developed validated high-throughput real-time quantitative PCR-based analysis platform, termed 'GUt Low-Density Array' (GULDA). The platform was designed simultaneous change abundance 31 different...
Postnatal regulation of the small intestinal mucus layer is potentially important in development adult gut functionality. We hypothesized that nature bacterial colonization affects gene early life.We thus analyzed influence presence a conventional microbiota as well two selected monocolonizing strains on transcription murine genes involved during first week life.Mouse pups (N = 8/group) from differently colonized dams: Germ-free (GF), specific pathogen free (SPF), monocolonized with either...
Abstract Circadian rhythms generated by the suprachiasmatic nucleus (SCN) are daily adjusted (entrained) light via retinohypothalamic tract (RHT). The RHT contains two neurotransmitters, glutamate and pituitary adenylate cyclase‐activating polypeptide (PACAP), which believed to mediate phase‐shifting effects of on clock. In present study we have elucidated role PACAP in light‐induced phase shifting at early night hamsters shown that (i) delay running‐wheel activity was significantly...
Certain indigestible carbohydrates, known as prebiotics, are claimed to be beneficial for gut health through a selective stimulation of certain microbes including bifidobacteria. However, such does not necessarily imply preventive effect against pathogen infection. We recently demonstrated reduced resistance Salmonella infection in mice fed diets containing fructo-oligosaccharides (FOS) or xylo-oligosaccharides (XOS). In the present study, faecal and caecal samples from same were analysed...
Abstract Preterm pigs show many signs of immaturity that are characteristic preterm infants. In infants, the cerebellum grows particularly rapid and hypoplasia cellular lesions associated with motor dysfunction cognitive deficits. We hypothesized functional brain delays observed in would be paralleled by both structural molecular differences relative to term born piglets. Cerebella were collected from ( n = 56) (90% gestation, 112) at 0, 5, 26 days after birth for stereological volume...
Duplicate platelet survival studies were carried out on 8 patients with giant cell arteritis (GCA), once before the institution of any therapy, and second time when they in a completely asymptomatic phase after having received corticosteroid treatment. The interval between ranged 5 14 months. In first study mean peripheral count was 486 +/- 25 X 10(9)/l 326 10(9)/l. difference means highly significant (P less than 0.001). life-span platelets normal duplicate experiments (6.7 0.3 7.3 0.4...
Summary Studies of the connection between reflexes and sucking ability underweight children have been performed on basis G esell's scheme in his work entitled The Embryology Behavior. In course routine examinations, some “tests” carried out by esell were‐found to be too subjective or impracticable. Accordingly, they were eliminated from definite examination scheme. series includes 33 prematures with a weight at birth varying 1,160 2,490 g. examinations so far suggest that maximum grasping...
To assess the microbial influence on postnatal hematopoiesis, we examined role of early life colonization composition leukocyte subsets in neonatal spleen. A high number CD11b(+)Gr-1(+) splenocytes present perinatally was sustained for a longer period conventionally colonized (CONV) mice than mono-colonized (MC) and germfree (GF) mice, CD4(+) T cell population established faster CONV mice. At day birth, compared to GF expression Cxcl2 up-regulated Arg1 down-regulated livers This coincided...
<h3>Background and aims</h3> Preterm birth is associated with an increased risk of brain injury, smaller volume cognitive deficits. To gain insight into how premature affects development in a pig model preterm birth, we evaluated the growth neocortex cerebellum using designed based stereology. <h3>Methods</h3> Piglets born or at term (postconceptional age (PA) 106 118, respectively) were euthanized on postnatal day 0, 5 26 (n = 1–22). The left cerebral cerebellar hemipheres fixed formalin,...
<h3>Background and aims</h3> Neurodevelopmental seqeulae of premature birth involve cognitive motor deficits, often persisting into adult life. The molecular mechanisms involved remain yet to be elucidated, but certain regions e.g. cerebellum neocortex appear particularly sensitive. current study aimed evaluate the relevance Brain derived neurotropic factor (BDNF), in formation synaptic connexions, Sonic Hedgehog (SHH), important for perinatal neuronal differentiation, as potential...