A5071982042- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Barrier Structure and Function Studies
- Viral Infections and Vectors
- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Intracerebral and Subarachnoid Hemorrhage Research
- MRI in cancer diagnosis
- Lipid metabolism and disorders
European Molecular Biology Laboratory
2021-2024
University of British Columbia
2020
Abstract The endoplasmic reticulum (ER) is a complex subcellular organelle composed of diverse structures such as tubules, sheets and tubular matrices. Flaviviruses Zika virus (ZIKV) induce reorganization ER membranes to facilitate viral replication. Here, using 3D super resolution microscopy, ZIKV infection shown the formation dense matrices associated with replication in central ER. Viral non-structural proteins NS4B NS2B associate complexes within ZIKV-induced matrix exhibit distinct...
Abstract Disruption of the vascular protective angiopoietin-Tie axis is common in cerebral malaria (CM) patients, with elevated angiopoietin-2 (Ang-2) and reduced angiopoietin-1 (Ang-1) blood concentrations. The role pericytes CM pathogenesis remains unexplored, despite being a major source brain Ang-1 secretion evidence pericyte damage observed postmortem samples. Here we engineered 3D microfluidics-based microvessel model containing both human primary microvascular endothelial cells...
Cerebral malaria is a severe neurovascular complication of Plasmodium falciparum with high mortality, even after treatment effective antimalarials. A better understanding pathogenic mechanisms could help future development adjunctive therapies, yet limitations in current experimental models have hindered our knowledge the disease. We developed 3D blood-brain barrier model enhanced properties using primary brain endothelial cells, astrocytes and pericytes. Exposure to parasite egress products...
Abstract The endoplasmic reticulum (ER) is a complex subcellular organelle composed of diverse structures such as tubules, sheets and tubular matrices. Flaviviruses Zika virus (ZIKV) induce reorganization membranes to facilitate viral replication. Here, using 3D super resolution microscopy, ZIKV infection shown the formation dense matrices associated with replication in central ER. Viral non-structural proteins NS4B NS2B associate complexes within ZIKV-induced matrix exhibit distinct ER...