A5037885605- Malaria Research and Control
- Mosquito-borne diseases and control
- Microtubule and mitosis dynamics
- Intracerebral and Subarachnoid Hemorrhage Research
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Lipid metabolism and disorders
- MRI in cancer diagnosis
- Erythrocyte Function and Pathophysiology
- Healthcare and Venom Research
- Iron Metabolism and Disorders
- Parasite Biology and Host Interactions
- Barrier Structure and Function Studies
European Molecular Biology Laboratory
2024
Heidelberg University
2019-2022
University Hospital Heidelberg
2019-2022
National Center for Infectious Diseases
2020
Article24 May 2019Open Access Source DataTransparent process Microtubule number and length determine cellular shape function in Plasmodium Benjamin Spreng Integrative Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Heidelberg, Germany Search more papers by this author Hannah Fleckenstein Patrick Kübler orcid.org/0000-0002-6079-5103 Claudia Di Biagio orcid.org/0000-0001-9096-3166 Madlen Benz Pintu Patra orcid.org/0000-0002-2275-3738 Institute Theoretical...
Abstract Disruption of the vascular protective angiopoietin-Tie axis is common in cerebral malaria (CM) patients, with elevated angiopoietin-2 (Ang-2) and reduced angiopoietin-1 (Ang-1) blood concentrations. The role pericytes CM pathogenesis remains unexplored, despite being a major source brain Ang-1 secretion evidence pericyte damage observed postmortem samples. Here we engineered 3D microfluidics-based microvessel model containing both human primary microvascular endothelial cells...
Cerebral malaria is a severe neurovascular complication of Plasmodium falciparum with high mortality, even after treatment effective antimalarials. A better understanding pathogenic mechanisms could help future development adjunctive therapies, yet limitations in current experimental models have hindered our knowledge the disease. We developed 3D blood-brain barrier model enhanced properties using primary brain endothelial cells, astrocytes and pericytes. Exposure to parasite egress products...
News & Views25 February 2019Open Access Binding brain better—matching var genes and endothelial receptors Hannah Fleckenstein Center for Infectious Diseases, Parasitology, Heidelberg University Hospital, Heidelberg, Germany Search more papers by this author Silvia Portugal Corresponding Author [email protected] orcid.org/0000-0003-4567-9101 Information Fleckenstein1 *,1 1Center EMBO Mol Med (2019)11:e10137https://doi.org/10.15252/emmm.201810137 See also: J Storm et al (February 2019)...