A5071043778- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Hepatitis B Virus Studies
- Healthcare and Venom Research
- Aquaculture disease management and microbiota
- Trypanosoma species research and implications
- Parasite Biology and Host Interactions
- HIV Research and Treatment
- Global Maternal and Child Health
- Invertebrate Immune Response Mechanisms
Université des Sciences, des Techniques et des Technologies de Bamako
2020-2024
Health Net
2023
Max Planck Institute for Infection Biology
2021
University of Bamako
2014
University of the Sciences
2013
In experimental models of human and mouse malaria, sterilizing liver stage immunity that blocks progression Plasmodium infection to the symptomatic blood can be readily demonstrated. However, it remains unclear whether individuals in malaria-endemic areas acquire such immunity.In Mali, 251 healthy children adults aged 4-25 years who were free blood-stage by polymerase chain reaction (PCR) enrolled a longitudinal study just prior an intense 6-month malaria season. Subsequent clinical episodes...
Background. Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) is a blood-stage parasite essential for host erythrocyte invasion. PfRH5-specific antibodies raised in animals inhibit growth vitro, but the relevance of naturally acquired humans unclear.
Abstract Following Plasmodium falciparum infection, individuals can remain asymptomatic, present with mild fever in uncomplicated malaria cases, or show one more severe symptoms. Several studies have investigated associations between parasite transcription and clinical severity, but no broad conclusions yet been drawn. Here, we apply a series of bioinformatic approaches based on P. ’s tightly regulated transcriptional pattern during its ~48-hour intraerythrocytic developmental cycle (IDC) to...
Intermittent Preventive Treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) is widely used for the control of malaria Africa. The emergence resistance to SP a concern requiring monitoring effectiveness IPTp. This was an in-vivo efficacy study determine parasitological treatment response and duration post-treatment prophylaxis among asymptomatic pregnant women receiving as part IPTp Mali Burkina-Faso. primary outcome PCR-unadjusted % patients parasites recurrence by day 42...
Persistence of malaria parasites in asymptomatic hosts is crucial areas seasonally-interrupted transmission, where P. falciparum bridges wet seasons months apart. During the dry season, infected erythrocytes exhibit extended circulation with reduced cytoadherence, increasing risk splenic clearance cells and hindering parasitaemia increase. However, what determines parasite persistence for long periods time remains unknown. Here, we investigated whether seasonality affects plasma composition...
Introduction: Antenatal care (ANC) is valuable in the fight against maternal mortality.It prevents or treats complications related to pregnancy and/or childbirth.To assess use of ANC services by pregnant women with presumptive malaria, we conducted a cross-sectional study.Methods: The study was from 03 21 November 2019 San health district.Our concerned childbearing age child less than 6 months old and residing district at time survey.Data were collected using Open Data Kit (ODK) version...