A5055901305- Telomeres, Telomerase, and Senescence
- RNA modifications and cancer
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Cell Adhesion Molecules Research
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Laser-Ablation Synthesis of Nanoparticles
- interferon and immune responses
- Metabolism, Diabetes, and Cancer
- Spaceflight effects on biology
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- ATP Synthase and ATPases Research
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Sirtuins and Resveratrol in Medicine
- Nanoparticles: synthesis and applications
- Cancer, Lipids, and Metabolism
- Adenosine and Purinergic Signaling
- Protease and Inhibitor Mechanisms
Rzeszów University
2017-2025
Cellular senescence may contribute to aging and age-related diseases senolytic drugs that selectively kill senescent cells delay promote healthspan. More recently, several categories of senolytics have been established, namely HSP90 inhibitors, Bcl-2 family inhibitors natural compounds such as quercetin fisetin. However, senostatic potential nanoparticles surface-modified has never addressed. In the present study, surface functionalized Fe3O4 (MNPQ) were synthesized their activity was...
The surface modification of magnetite nanoparticles (Fe3O4 NPs) is a promising approach to obtaining biocompatible and multifunctional nanoplatforms with numerous applications in biomedicine, for example, fight cancer. However, little known about the effects Fe3O4 NP-associated reductive stress against cancer cells, especially chemotherapy-induced drug-resistant senescent cells. In present study, NPs situ coated by dextran (Fe3O4@Dex) glucosamine-based amorphous carbon coating (Fe3O4@aC)...
Cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that promote inflammation paracrine secondary in healthy tissues. DNMT2/TRDMT1 methyltransferase is implicated the regulation cellular lifespan DNA damage response (DDR). In present study, responses to inducing concentrations doxorubicin etoposide different cancer cells with gene knockout were evaluated, namely changes cell cycle, apoptosis, autophagy, interleukin levels, genetic stability DDR, 5-mC...
Lapatinib (L) and fulvestrant (F) are used in targeted anticancer therapies, particular, against phenotypically different breast cancer cells. L, a dual inhibitor of EGFR HER2 tyrosine kinases, is active HER2-positive cells, while F, selective estrogen receptor degrader (SERD), ER-positive However, the action L F can be limited due to their relatively low water solubility bioavailability. In present study, poly(amidoamine) (PAMAM) dendrimer G3 was functionalized with or compare effects free...
Drug-induced senescence program may be activated both in normal and cancer cells as a consequence of chemotherapeutic treatment, leading to some adverse side effects such senescence-associated secretory phenotype (SASP), secondary senescence, promotion. Targeted elimination senescent can achieved by drugs with senolytic activity (senolytics), for example, the plant-derived natural compound quercetin, especially when co-treated kinase inhibitor dasatinib. In present study, three quercetin...
Urotropine, an antibacterial agent to treat urinary tract bacterial infections, can be also considered as a repurposed drug with formaldehyde-mediated anticancer activity. Recently, we have synthesized urotropine surface modified iron oxide nanoparticles (URO@Fe3O4 NPs) improved colloidal stability and limited cytotoxicity against human fibroblasts. In the present study, investigated URO@Fe3O4 NP-mediated responses in panel of forty phenotypically different breast cancer cell lines along...
Background/Objectives: Oxidative stress is a factor that may adversely affect the development of foetus, course labour, and newborn health. This study aimed to determine association between labour method, oxidative parameters, neonatal condition. Methods: The material was umbilical cord blood from newborns delivered vaginally (n = 60) or by caesarean section 108). total antioxidant status (TAS), superoxide dismutase activity (SOD), glutathione peroxidase (GPx), reductase (GR) were determined...
Remifentanil and other opioids are suggested to be protective against ischemia-reperfusion injury in animal models coronary artery bypass surgery patients, however the molecular basis of such protection is far from being understood. In present study, we have used a model human cardiomyocytes treated with hypoxia-mimetic agent cobalt chloride investigate remifentanil preconditioning-based adaptive responses underlying mechanisms. Hypoxic conditions promoted oxidative nitrosative stress,...
Abstract The acidic, hypoxic and nutrient-deprived tumor microenvironment may induce endoplasmic reticulum (ER) stress the unfolded protein response (UPR) exert an important cytoprotective role by promoting folding of newly synthesized proteins cancer cell survival. lack DNMT2/TRDMT1 methyltransferase-mediated C38 tRNA methylation compromises translational fidelity that result in accumulation misfolded aggregated leading to proteotoxic stress-related death. In present study, gene...
Mitochondria, the main cellular power stations, are important modulators of redox-sensitive signaling pathways that may determine cell survival and death decisions. As mitochondrial function is essential for tumorigenesis cancer progression, targeting has been proposed as an attractive anticancer strategy. In present study, three mitochondria-targeted quercetin derivatives (mitQ3, 5, 7) were synthesized tested against six breast lines with different mutation receptor status, namely...
The accumulation of senescent cells, a hallmark aging and age-related diseases, is also considered as side effect anticancer therapies, promoting drug resistance leading to treatment failure. use senolytics, selective inducers cell death in promising pharmacological antiaging approach. However, more studies are needed overcome the limitations first-generation senolytics by design targeted nanosenolytics validation their usefulness biological systems. In present study, we have designed...
Pregnancy and childbirth are associated with the forming of reactive oxygen species that generate oxidative stress. Oxidative stress is a factor may adversely affect development fetus course labour. Monitoring parameters can be used to assess risk health issues in pregnancy condition newborn. Therefore, analysis physiological labour basis for understanding role pathogenesis miscarriages neonatal circumstances. The study aimed mother-child pairs venous blood umbilical cord at time One hundred...
Magnetic nanoparticle (MNP) anisotropy has been tailored by the preparation of MNPs having different shapes (star-like, cubic, and polyhedral) using a self-modified rapid hot-injection process. The surface modification was performed through etidronic ligand grafting with strong binding affinity to mixed metal oxides, ensuring sufficient colloidal stability, protection, minimized aggregation interparticle interactions. heating effect induced contactless external stimulation action an...
Testing and screening of plant-derived molecules on normal human cells in vitro is a widely used approach for discovering their eventual health beneficial effects ageing longevity. As little known about age-associated differential such molecules, here we report that young (<25% replicative lifespan completed) near-senescent (>90% skin fibroblasts exposed 1–15 days to wide range concentrations (0.1–100 μM) the three selected phytochemicals, namely α-boswellic acid acetate (ABC),...
Osteosarcoma (OS) is a pediatric malignant bone tumor with unsatisfying improvements in survival rates due to limited understanding of OS biology and potentially druggable targets. The present study aims better characterize osteosarcoma U-2 OS, SaOS-2, MG-63 cell lines that are commonly used as vitro models OS. We focused on evaluating the differences death pathways, redox equilibrium, activity proliferation-related signaling DNA damage response, telomere maintenance, DNMT2/TRDMT1-based...