Abstract Among natural products, essential oils from aromatic plants have been reported to possess potent anticancer properties. In this work, we aimed perform the cytotoxic concentration range screening and antiproliferative activity of chemically characterized Thymus vulgaris L. oil. vivo bioassay was conducted using brine shrimp lethality test (BSLT). vitro evaluation carried out on three human tumor cell lines: breast adenocarcinoma MCF-7, lung carcinoma H460 acute lymphoblastic leukemia...

The genetic, morphological and taxonomic diversity of the genus Sorbus is due to homoploid polyploid hybridisation, autopolyploidy apomixis, which also influence production secondary metabolites, especially flavonoids. aim this study was investigate relationships variations flavonoids in terms hybrid origin ploidy level between parental species their derivatives. sampling design included leaf material following accessions from ten natural localities: taxa (di-, tri- tetraploids S. aria;...

Red currant (Ribes rubrum L.) berries are rich in bioactive compounds and exhibit nutritive protective features. This research examined the content of secondary metabolites red variety Redpoll lyophilized juice waste extract their antioxidative spasmolytic effects. The flavonol anthocyanin contents samples were determined using high-performance liquid chromatography. antispasmodic effects assessed vitro conditions, potential impact possible action mechanisms revealed. results showed...

Cilj ovog istraživanja bio je utvrditi antioksidacijsko djelovanje i ukupni fenolni sastav svježih listova Sempervivum tectorum L. s obzirom na provenijenciju iz urbane ruralne sredine. Svježi listovi biljnog materijala čuvarkuće prikupljeni su za sunčanog dana sredinom lipnja 2024. god. Homogenizirani uzorak podvrgnut ekstrakciji maceracije sobnoj temperaturi uz uporabu destilirane vode vodene otopine etanola 70 % 50 te metanola %. Ukupni sadržaj fenola određen Folin-Ciocalteu metodom, a...

The current state of research on the anti‑SARS‑CoV‑2 potential artemisinin‑related compounds has identified arteannuin B as a potent inhibitor nCoV‑2019BetaCov/Wuhan/WiV04/2019 and BetaCov/Italy/CDG1/2020 strains virus. aim this work was to fractionate targeted sesquiterpenoid compounds, artemisinin, from complex matrix crude ethanolic leaf extract Artemisia annua L. using high‑speed countercurrent chromatography (HSCCC) test simplified or purified fractions against genomically characterized...

Introduction: Present study describes the antimicrobial activity and free radical scavenging capacity (RSC) of essential oil from Mentha longifolia (L.) Huds. Aim this to investigate quality, andantioxidant wild species Bosnia Herzegovina.Methods: The chemical profi le was evaluated by means gas chromatography-mass spectrometry (GC-MS) thin-layer chromatography (TLC). Antimicrobial tested against 6bacterial strains. RSC assessed measuring oils on 2,2- diphenyl-1-picrylhydrazil...

Five methanolic extracts obtained from different parts of birch, Betula pendula, Roth. (external and internal bark, flowers, leaves buds), were evaluated for their antibacterial activity in this study. Triterpene compounds, betulin, betulinic acid, oleanolic acid lupeol, isolated the external birch bark using method dry column chromatography (DCC) as well preparative thin layer (TLC). These compounds also investigated activity. Taking into account that decoction is most commonly used...

Platelet hyperactivity and platelet interaction with endothelial cells contribute to the development progression of many cardiovascular diseases such as atherosclerosis thrombosis. The impact activity different pharmacological agents, acetylsalicylic acid coumarin derivatives, has been shown be effective in prevention disease. Artemisia dracunculus, L. Asteraceae (Tarragon) is used for centuries daily diet Middle Eastern countries, it well known its anticoagulant activity. present study...

Plant-derived products are frequently found as ingredients in cosmetics. However, the current data show non-neglectable skin sensitizing potential of these preparations suggesting an urgent need for regarding their health safety profile. The aim this study was to assess sensitization commercial essential oils by selected Lamiaceae species (Lavandula angustifolia, Melissa officinalis, Mentha longifolia, Thymus vulgaris, Salvia and Rosmarinus officinalis) using a chemistry-based Direct Peptide...

Introduction: We studied the chemical composition and antimicrobial, antioxidant, antiproliferative activities of essential oils from flowers Lavandula angustifolia grown in Southern Bosnia Herzegovina.
 Methods: The profile oil was evaluated by means gas chromatography-mass spectrometry. Antimicrobial activity tested against six bacterial strains. antioxidant 1,1-diphenyl-2-picrylhydrazyl (DPPH) test three human cancer cell lines, MCF-7, NCI-H460, MOLT-4, were investigated using...

AbstractThe study aimed to analyse the potential of Lamiaceae essential oils, extracts, and hydrolats against bacterial biofilms. Bacterial cells Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus were exposed Thymus vulgaris L. (thyme), Salvia officinalis (sage), Mentha × piperita (mint) hydrolats. The result minimal inhibitory concentration assessment shows highest antibacterial for followed by extracts respectively. anti-biofouling capacity revealed that thyme oil has biofilm...

In the present study, we investigated antiproliferative activity of essential oil from leaves Melissa officinalis L. grown in Southern Bosnia and Herzegovina.In vitro evaluation M. was carried out on three human tumor cell lines: MCF-7, NCI-H460 MOLT-4 by MTT assay.M. characterized high percentage monoterpenes (77,5%), followed sesquiterpene fraction (14,5%) aliphatic compounds (2,2%).The main constituents are citral (47,2%), caryophyllene oxide (10,2%), citronellal (5,4%), geraniol (6,6%),...

Lavandula angustifolia Mill. is the most important genus in Lamiaceae as it contains species with essential oils of a high economic value. Lavender oil used pharmaceutical, perfume and confectionery industries. Although L. commercially cultivated many regions world, grows wild Balkans. The present study was designed to describe qualitative quantitative composition evaluate, vitro, its antiproliferative effects. Essential were obtained by steam distillation (Clevenger type). chemical profile...

<p><strong>Aim</strong> <br />There are more and herbal preparations that used for the purpose of treatment improvement clinical manifestation vaginitis not only by patients themselves, but also healthcare professionals. Plant species, St. John’s wort, chamomile, calendula, yarrow, shepherd’s purse tea tree oil all well known their anti-inflammatory, antimicrobial wound healing activity. This paper presents...

Considering that a register for cancer was established in Federation of Bosnia and Herzegovina only recently, basic reliable source the analysis mortality trends are data on death cases caused by such diseases. Lack census as well standardized mortalityrate makes study even more difficult to make. The aim is malign diseases trend post-war period according available data. descriptive work system using linear regression methods expected total population age group from 0 64 years. Registered...

Asthma is the most common chronic illness in children and adolescents. The pediatric "Asthma School" has been established to improve health quality of life with asthma through education support. purpose work evaluation efficiency adolescents, parents prevention, adequate use medications control asthma. It was operational investigation. study enrolled 70 participants from 7 cities FBiH, which were attended School". Evaluations program have done questionnaires using 5-point scale. Observing...

Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint inflammation and destruction, leading to significant pain disability. Adenosine deaminase (ADA) identified as biomarker for RA’s process. This study aims investigate the potential of flavonoids phenolic acids inhibit ADA activity (in silico) evaluate their anti-inflammatory effects in RA model vivo). Methods: The molecular docking was conducted using YASARA Structure 19.12.14. software following...

Cilj ovoga istraživanja bio je utvrditi antioksidacijsku aktivnost i sadržaj ukupnih fenola svježeg osušenog lista ružmarina s obzirom na provenijenciju iz urbane ruralne sredine, te usporediti dobivene rezultate rezultatima komercijalnog uzorka. Listovi biljnog materijala R. officinalis skupljeni su tijekom svibnja lipnja 2024. god. u ljetnom/sunčanom periodu. Homogenizirani uzorak podvrgnut maceraciji sobnoj temperaturi uz uporabu destilirane vode 70%-tne otopine etanola. Ukupni određen...

Triterpenes are very important secondary metabolites with wide structural diversity and significant role in pharmacy medicine.In the present research, a comparative study of pharamacological activities triterpene fractions obtained from several plant species belonging to Lamiaceae family, was carried out. In-vitro anti-proliferative activity performed using standardproliferation assay based on tetrazolium salts. In vitro anti-inflammatory determined by an inhibition albumin denaturation....

Food allergy most often begins in the first 1 to 2 years of life with process sensitization, by which immune system responds specific food proteins. Symptoms a reaction commonly involve localized hives and worsening eczema, moderate-to-severe atopic dermatitis frequent comorbid condition allergy. Acute urticaria is much more likely be caused than chronic urticaria.

Introduction: Bosnia and Herzegovina has a high prevalence of smoking among women, especially health care professionals. The goal this study is to investigate the influence social environment women employed in institutions relation cigarettes habits.Methods: included 477 hospitals, outpatient public Sarajevo Canton Herzegovina. We used modifi ed questionnaire assessing habits medical staff European hospitalsResults: results showed that 50% are smokers, with highest incidence nurses (58.1%)...

Background The pediatrician plays an important role in contributing to the management of children with food allergies. Antihistamine drugs are used control or alleviate allergy symptoms like, skin rash hives and breathing difficulties, by counteracting effects histamine. Dexamethasone is a potent corticosteroid it acts as anti-inflammatory immunosuppressant. Adrenaline epinephrine drug choice for treating anaphylaxis.