A5065471713- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Advanced Biosensing Techniques and Applications
- Coral and Marine Ecosystems Studies
- Marine Toxins and Detection Methods
- Microbial Community Ecology and Physiology
- interferon and immune responses
- Vibrio bacteria research studies
- Aquaculture disease management and microbiota
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Electrochemical sensors and biosensors
- Marine and coastal ecosystems
- Analytical Chemistry and Sensors
- Marine Sponges and Natural Products
- Environmental Toxicology and Ecotoxicology
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Collagen: Extraction and Characterization
- Cancer Research and Treatments
- Protist diversity and phylogeny
- Fecal contamination and water quality
- Chemokine receptors and signaling
- Ocean Acidification Effects and Responses
Philips (United Kingdom)
2023
University of Technology Sydney
2013-2023
University of Technology
2014
Macquarie University
2013
Universitat Autònoma de Barcelona
2008-2011
Institut de Microelectrònica de Barcelona
2008-2011
Consejo Superior de Investigaciones Científicas
2010-2011
Centro Nacional de Microelectrónica
2008-2009
This paper presents an immunosensing system to detect Escherichia coli and Salmonella based on electrochemical impedance spectroscopy at interdigitated electrode structures. Our results show the importance of good design in final detection limit. Four different structures have been fabricated functionalized. Biotinylated polyclonal antibodies immobilized neutravidin-coated chips, BSA has used avoid nonspecific adsorption. The immunosensor may be said capacitive since it is that part monitor...
Corals are among the most active producers of dimethylsulfoniopropionate (DMSP), a key molecule in marine sulfur cycling, yet specific physiological role DMSP corals remains elusive. Here, we examine oxidative stress response three coral species ( Acropora millepora , Stylophora pistillata and Pocillopora damicornis ) explore antioxidant its breakdown products under short-term hyposalinity stress. Symbiont photosynthetic activity declined with exposure all reef-building corals. This...
Ciguatera Fish Poisoning (CFP) is a human illness caused by the consumption of marine fish contaminated with ciguatoxins (CTX) and possibly maitotoxins (MTX), produced species from benthic dinoflagellate genus Gambierdiscus. Here, we describe identity toxicology Gambierdiscus spp. isolated tropical temperate waters eastern Australia. Based on newly cultured strains, found that four were present at location, including G. carpenteri, lapillus two others which not genetically identical to other...
TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε), can also induce pro-inflammatory responses that contribute to pathogen clearance. While initially protective, sustained engagement interferons associated with damaging hyper-inflammation found severe COVID-19 patients. The contribution TBK1/IKKε these unknown. Here we find...
Ciguatera Fish Poisoning (CFP) is a tropical disease caused by the consumption of fish contaminated with ciguatoxins (CTXs). Currently, only feasible prevention methods for CFP are to avoid certain species from some regions, larger species, or all caught specific regions. Here, we quantified levels P-CTX-1B in Spanish Mackerel (Scomberomorus commerson), which main that causes New South Wales and Queensland, Australia, using LC-MS detection against toxin standard. We found detectable both...
Abstract Recognition of RNA fragments by Toll-like receptors (TLR) 7 and 8 is a key contributor to the initiation protective innate immune response against pathogens. A long-standing enigma how degradation products host RNAs, generated daily phagocytic clearance billions apoptotic cells, fail activate TLR7 TLR8 signalling 1 . Here, we report that select 2’-O-methyl (2’-Ome) guanosine as short 3 bases, including those derived from host-RNAs, are potent antagonists reduce sensing in vivo...
Testosterone is one of the androgenic steroid hormones, consumption which considered doping in most sports. Here, we present powerful 3D sensing platforms using novel disc-ring microelectrode array devices and exploit them for competitive immunosensing testosterone. Each device contains a that consists large number individual microdiscs used as substrate immunofunctionalization assay performance. One micrometer above it, second array, this time consisting microrings, working electrode...
The immunosuppressive tumor microenvironment is a major barrier for chemotherapy. Different chemosensitization approaches to reinstate immunological surveillance cancers that are immune quiescent at the outset, have thus been devised. Cancer-specific ENOX2 expression correlated with abnormal cell growth and has proposed as cellular target anti-cancer activity. However, potential effects of on interaction between system cells remain elusive. To understand mechanisms by which tumor-intrinsic...
Abstract Mass production of bioactive compounds was enhanced by the addition particular trace metals to specific microalgae. An increase in domoic acid isomer-C Pseudo-nitzschia australis achieved adding copper (Cu) or Zinc (0.1–0.2μmol l−1) standard growth media. The combined selenium (Se) and Magnesium (0.1μmol l−1 3.6μmol respectively) elicited a 58% gymnodimine Karenia selliformis. Addition Cu (0.16μmol resulted 100% palytoxin-related Ostreopsis siamensis 50% okadaic diol esters produced...
Electrochemical detection of <italic>Vibrio parahaemolyticus</italic> cells at a minimum abundance 4 × 10<sup>2</sup> per mL within 60 min.
There is an urgent need to develop and implement rapid assessments of coral health allow effective adaptive management in response coastal development global change. now increasing evidence that activation caspase-dependent apoptosis plays a key role during bleaching subsequent mortality. In this study, “clinical” approach was used assess by measuring the activity caspase 3 using commercial kit. This method first applied while inducing thermal two species, Acropora millepora Pocillopora...
Bacteria from the genus Vibrio are a common and environmentally important group of bacteria within coastal environments include species pathogenic to aquaculture organisms. Their distribution abundance linked specific environmental parameters, including temperature, salinity nutrient enrichment. Accurate efficient detection Vibrios in samples provides potential indicator overall ecosystem health while also allowing rapid management responses for humans or implicated disease economically...
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to therapy. Stromal cancer-associated fibroblasts (CAFs) play a key role in promoting tumor progression and chemoresistance, by creating fibrotic microenvironment that impedes drug access feeds PDAC cells nutrients pro-tumor signals. CRO-67 (Patent PCT/AU2023/050505) novel developed with Noxopharm Ltd using rational medicinal chemistry design improve bioavailability of chromans which have potent anti-cancer...