A5103231011- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Synthesis and Characterization of Heterocyclic Compounds
- Spectroscopy and Quantum Chemical Studies
- Kidney Stones and Urolithiasis Treatments
- Polydiacetylene-based materials and applications
- Supramolecular Self-Assembly in Materials
- Inflammasome and immune disorders
- Microwave-Assisted Synthesis and Applications
- Fluorine in Organic Chemistry
- Supramolecular Chemistry and Complexes
- Food Chemistry and Fat Analysis
- Energetic Materials and Combustion
- Urinary Tract Infections Management
- Synthesis and Catalytic Reactions
- Lipid Membrane Structure and Behavior
- interferon and immune responses
- Chemical Synthesis and Analysis
- Photochromic and Fluorescence Chemistry
- Viral Infections and Vectors
- Microbial Natural Products and Biosynthesis
- Crystallography and molecular interactions
- Oral microbiology and periodontitis research
UNSW Sydney
2017-2023
Kensington Health
2017
TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε), can also induce pro-inflammatory responses that contribute to pathogen clearance. While initially protective, sustained engagement interferons associated with damaging hyper-inflammation found severe COVID-19 patients. The contribution TBK1/IKKε these unknown. Here we find...
Introduction Proteus mirabilis is a key pathobiont in catheter-associated urinary tract infections (CA-UTIs), which well known to form crystalline biofilms that occlude catheters. Urease activity alkylates urine through the release of ammonia, consequentially resulting higher levels Mg 2+ and Ca formation crystals. In this study, we showed N -acetyl cysteine (NAC), thiol antioxidant, potent urease inhibitor prevents biofilm formation. Methods To quantify activity, Berthelot’s method was done...
Precise control of tape spacing in hydrogen-bonded alkyl-chain substituted chloro-<italic>s</italic>-triazines is demonstrated at 150–298 K, with some unexpected behaviour from the odd-number carbon derivatives.
First example of glyoxylamide-based short peptides which can encapsulate organic solvents and water at relatively low concentrations.
Abstract Crystalline bis‐ N ‐alkyl‐chlorotriazines 2 – 6 can be considered multilayers of lipid bilayers comprising a rigid hydrogen‐bonded tape in the polar layer separated by region small to medium‐length alkyl chains. The persistent ordering these tapes acts as scaffold solid state enabling measurement temperature‐induced conformational changes “lipid phase” using X‐ray crystallography. chains structures are loosely packed but generally ordered at low temperature, undergoing slow...
The bis-glyoxylamide peptidomimetics have been synthesized from bis-N-acetylisatins linked at C5 by ring-opening with alcohols, amines, and amino acid methyl ester hydrochlorides. X-ray images of single crystals obtained.
Ensuring a consistent crystal structure over wide temperature range can be desirable behaviour in organic devices. This study investigates layered system formed by hydrogen-bonded chloro-s-triazine rings functionalised with alkyl or fluoroalkyl chains between the layers. When substituted N-propyl groups (C3), undergoes thermally-induced phase transition where are ordered and bent below 170 K disordered extended above 175 K. Replacement fluorinated (C3-F) produces same but successfully...
Self-complementary hydrogen-bonded systems such as the O-H…O carboxylic acid dimer are well known supramolecular synthons for crystal engineering [1].Here we explore a self-complementary system using N-H…N hydrogen-bonds formed by chloro-s-triazine (1), heterocyclic that includes ubiquitous herbicides atrazine and simazine.These compounds have emerged robust components form NH...N tapes (2) in solid state.A search of CCDC reveals numerous examples (1) assembling into variants tape where...