A5102023996- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Attention Deficit Hyperactivity Disorder
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Chemical synthesis and alkaloids
- Psychedelics and Drug Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Schizophrenia research and treatment
University of Cambridge
2019-2023
University of Copenhagen
2017-2023
Bispebjerg Hospital
2016-2019
Copenhagen University Hospital
2016-2019
Frederiksberg Hospital
2017
Rigshospitalet
2016
Much evidence suggests that reversal learning is mediated by cortico-striatal circuitries with the orbitofrontal cortex (OFC) playing a prominent role. The OFC functionally heterogeneous region, but potential differential roles of lateral (lOFC) and medial (mOFC) portions in visual have yet to be determined. We investigated effects pharmacological inactivation mOFC lOFC on deterministic serial task for rats. For reference, we also targeted other areas previously implicated learning:...
Abstract Impaired cognitive flexibility in visual reversal-learning tasks has been observed a wide range of neurological and neuropsychiatric disorders. Although both human animal studies have implicated striatal D 2 -like 1 receptors (D2R; D1R) this form flexibility, less is known about the contribution they make within distinct sub-regions striatum different phases reversal learning. The present study investigated involvement D2R D1R during early (perseverative) phase learning as well...
Abstract Background Work in humans has shown that impulsivity can be advantageous certain settings. However, evidence for so-called functional is lacking experimental animals. Aims This study investigated the contexts which high impulsive (HI) rats show an advantage performance compared with mid- (MI) and low (LI) rats. We also assessed effects of dopaminergic noradrenergic agents to investigate underlying neurotransmitter mechanisms. Methods tested on a variable inter-trial interval (ITI)...
Adapting behavior to a dynamic environment requires both steadiness when the is stable and behavioral flexibility in response changes. Much evidence suggests that cognitive flexibility, which can be operationalized reversal learning tasks, mediated by cortico-striatal circuitries, with orbitofrontal cortex (OFC) playing prominent role. The OFC functionally heterogeneous region, we have previously reported differential roles of lateral (lOFC) medial (mOFC) regions touchscreen serial visual...
Negative urgency describes the tendency for rash and impulsive behaviour during negative emotional states has been linked to a number of psychiatric disorders. However, there limited research on as an explanatory mechanism impulsivity in experimental animals. Such important implications elucidating neurobiology thereby development future therapeutic interventions. In this study, we investigated effects using partial reinforcement schedule increase frequency non-rewarded (i.e. frustrative)...
Attention is compromised in many psychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD). While dopamine and noradrenaline systems have been implicated ADHD, their exact role attentional processing yet unknown.We applied the theory of visual attention (TVA) model, adapted from human research, to rat 5-choice serial reaction time task (5CSRTT) investigate catecholaminergic modulation healthy subjects high- low-attention phenotypes.Rats trained on standard 5CSRTT...
ABSTRACT Cognitive flexibility, the ability to adapt behavior in response a changing environment, is disrupted several neuropsychiatric disorders, including obsessive–compulsive disorder (OCD) and major depressive (MDD). Evidence suggests that which can be operationalized using reversal learning tasks, modulated by serotonergic transmission. However, how exactly flexible associated reinforcement (RL) processes are 5-HT action on specific receptors unknown. We investigated effects of 2A...