A5106033165- Urinary Bladder and Prostate Research
- Neurotransmitter Receptor Influence on Behavior
- Pancreatic function and diabetes
- Nitric Oxide and Endothelin Effects
- Metabolism, Diabetes, and Cancer
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Amyotrophic Lateral Sclerosis Research
- Diabetes and associated disorders
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Child Nutrition and Feeding Issues
- Electroconvulsive Therapy Studies
- Ion channel regulation and function
- Neuroscience of respiration and sleep
- Parasitic Infections and Diagnostics
- Eicosanoids and Hypertension Pharmacology
- Bladder and Urothelial Cancer Treatments
- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Pelvic floor disorders treatments
- Gastroesophageal reflux and treatments
- Diet and metabolism studies
- Intestinal Malrotation and Obstruction Disorders
- Synthesis and Reactivity of Heterocycles
Hospital Universitario de La Princesa
2023
Nutrition & Santé (Spain)
2010
Recordati (Italy)
2001-2006
Universidad del Valle
2004
Universidad de Salamanca
1994-1998
Mario Negri Institute for Pharmacological Research
1997
Istituto di Farmacologia Traslazionale
1997
New York Medical College
1974-1988
Metropolitan Hospital Center
1988
Purdue University West Lafayette
1975
Several novel N-arylpiperazine derivatives were synthesized and tested for their 1) affinity functional activity on 5-hydroxytryptamine(1A) (5-HT(1A)) receptors in vitro; 2) models predictive of antagonism at somatodendritic postsynaptic 5-HT(1A) receptors; 3) effects the micturition reflex anesthetized conscious rats. These studies also included 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (NAN 190), 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4,...
OBJECTIVE To investigate the role of cyclooxygenase (COX) isozymes (COX‐1 and ‐2) in regulation bladder volume capacity (BVC) several rat urodynamic models, using a selection nonsteroidal anti‐inflammatory drugs (NSAIDs), some selective for COX‐2, correlating potency tested compounds models their vitro as inhibitors COX isozymes, to verify relative importance different isozymes. MATERIALS AND METHODS The effects an i.v. administration nonselective COX‐2 (indomethacin, meloxicam, naproxen,...
A study was made of the effects 5‐carboxamidotryptamine (5‐CT) on pressor responses induced in vivo by electrical stimulation sympathetic outflow from spinal cord pithed rats. All animals had been pretreated with atropine. Sympathetic (0.1, 0.5, 1 and 5 Hz) resulted frequency‐dependent increases blood pressure. Intravenous infusion 5‐CT at doses 0.01, 0.1 μg kg −1 min reduced obtained stimulation. The inhibitory effect significantly more pronounced lower frequencies In present we...
To evaluate the effects of antagonists different subfamilies 5-hydroxytryptamine (5-HT) receptors on bladder function in anaesthetized and conscious rats. MATEERIALS AND METHODS: The urinary female rats was catheterized urethrally filled with physiological saline until spontaneous contractions occurred. Infravesical pressure measured by a transducer displayed continuously chart recorder. time quiescence (to disappearance rhythmic contractions) after injection compounds tested recorded....
To evaluate the effect of nonselective purinergic antagonist suramin and alpha1-adrenergic antagonists, terazosin BMY 7378, given intravenously or infused directly into bladder during cystometry in conscious rats with outlet obstruction induced by urethral ligation.Cystometry was performed female recording volume capacity (BVC), evaluated as amount saline between two voiding cycles, micturition (MV). Changes frequency amplitude spontaneous non-voiding contractions (NVC) were also recorded....
A study was made of the effects 5‐hydroxytryptamine (5‐HT) on pressor response induced in vivo by electrical stimulation sympathetic outflow from spinal cord pithed rats. All animals had been pretreated with atropine. Intravenous infusion at doses 10 and 20 μg kg −1 min reduced obtained intervals over 1 h infusion. This inhibitory action 5‐HT depressed cyproheptadine methiothepin but not modified ketanserin or MDL‐72222. By contrast, lost rats that exogenous noradrenaline. The receptor...
Antimuscarinic agents are the most popular treatment for overactive bladder and their efficacy in man is well documented, producing decreased urinary frequency an increase capacity. During cystometry rats, however, main effect reported after acute with antimuscarinics a decrease peak micturition pressure together little or no on In present experiments we studied effects, of two widely used antimuscarinic drugs, namely oxybutynin tolterodine, utilising several different cystometrographic...
Abstract The antihypertensive activity of eighteen oxazolo[3,2-a]pyridine, fhiazolo[3,2-a]pyridine and pyrido[2,1-b]oxazine derivatives has been evaluated in conscious spontaneously hypertensive rats (SHRs), compared with that nifedipine, used as reference. At a dose 50 mg kg−1 (i.p.) eleven compounds resulted significant reduction mean arterial blood pressure; four the were particularly effective, resulting hypotension more than 6 h after administration an effect was still apparent 24 h....
N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) cyclohexanecarboxamide (Rec 15/3079) was synthesized with the aim of obtaining a novel compound 5-hydroxytryptamine (5-HT)(1A) antagonistic properties and activity in controlling bladder function at level central nervous system. Rec 15/3079 showed selective high affinity for 5-HT(1A) receptor (K(i) = 0.2 nM). At human recombinant receptor, acted as competitive, neutral antagonist that it did not modify basal...
We examined the effects of intravenous administration 2 nuclear factor-kappaB inhibitors aspirin and 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) on bladder filling voiding in anesthetized conscious rats.Disappearance isovolumic contractions after different doses HTB anesthetized, transurethrally catheterized rats was evaluated. Cystometry performed during infusion with saline or diluted acetic as well those cyclophosphamide induced cystitis. Changes capacity pressure were evaluated test...