A5101944638- Pulmonary Hypertension Research and Treatments
- Brucella: diagnosis, epidemiology, treatment
- Leprosy Research and Treatment
- Cancer-related molecular mechanisms research
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Otolaryngology and Infectious Diseases
- RNA modifications and cancer
- History of Medicine and Tropical Health
- Hematological disorders and diagnostics
- Tuberculosis Research and Epidemiology
- Public Health and Social Inequalities
- Diabetes Treatment and Management
- Lymphadenopathy Diagnosis and Analysis
- Cardiovascular Function and Risk Factors
- Medicine and Dermatology Studies History
- Prion Diseases and Protein Misfolding
- Bacterial Identification and Susceptibility Testing
- Vibrio bacteria research studies
- Influenza Virus Research Studies
- Fungal Infections and Studies
- Metabolism, Diabetes, and Cancer
- Virology and Viral Diseases
- Pediatric health and respiratory diseases
- Cancer Cells and Metastasis
Centro de Investigaciones Biológicas Margarita Salas
2024
Imperial College London
2020-2022
Rationale: Idiopathic and heritable pulmonary arterial hypertension (PAH) are rare but comprise a genetically heterogeneous patient group. RNA sequencing linked to the underlying genetic architecture can be used better understand pathology by identifying key signaling pathways stratify patients more robustly according clinical risk.Objectives: To use three-stage design of discovery, validation model construction, define set PAH-associated RNAs single summarizing score. genes most likely...
Abstract Idiopathic pulmonary arterial hypertension (IPAH) is a rare but fatal disease diagnosed by right heart catheterisation and the exclusion of other forms hypertension, producing heterogeneous population with varied treatment response. Here we show unsupervised machine learning identification three major patient subgroups that account for 92% cohort, each unique whole blood transcriptomic clinical feature signatures. These are associated poor, moderate, good prognosis. The poor...
Abstract Aims/hypothesis Although targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase (AMPK) control insulin secretion is still debatable. Previous studies have pharmacological activators limited selectivity and specificity, none has examined primary pancreatic beta cells actions latest generation highly potent specific that act via allosteric drug metabolite (ADaM) site. Methods AMPK was activated acutely islets...
While studying the biological properties of hemolytic streptococci isolated from different sources in this Island, we grouped 46 strains using precipitin reaction described by Lancefield. All extracts were first tested against group A serum. Those that gave a positive test not tried other sera because cross reactions have never been observed with particular antiserum. doubtful or negative result same B, C, D, E, F, G and H antisera. Out 11 diseased tonsils, 7 belonged to A, 2 C remained...
Expression quantitative trait loci (eQTL) can provide a link between disease susceptibility variants discovered by genetic association studies and biology. To date, eQTL mapping have been primarily conducted in healthy individuals from population-based cohorts. Genetic effects known to be context-specific vary with changing environmental stimuli. We transcriptome- genome-wide study cohort of patients idiopathic or heritable pulmonary arterial hypertension (PAH) using RNA sequencing (RNAseq)...
<title>Abstract</title> Cadherin 17 (CDH17) plays a crucial role in the metastatic progression of colorectal cancer (CRC) through its interaction with α2β1 integrin. To further elucidate molecular mechanisms involving CDH17 functions CRC, we examined global expression alterations following silencing various cell lines. Loss resulted marked down-regulation stem (CSC) marker LGR5, leading to inhibition Wnt/β-catenin signaling, suppression pluripotency genes like MYC, and subsequent reduction...
The precipitin reaction has been used in an attempt to develop a simple and rapid method by which strains of Brucella melitensis can be differentiated from those abortus. Strains utilized for the immunization rabbits were B. 428 abortus 456 obtained National Institute Health at Washington, suis 1529, isolated Huddleson 1931 supramammary gland hog.The organisms grown 48 hours on freshly prepared tryptose agar slant growth suspended 0.9% saline, opacity adjusted match barium sulphate standard...
Pulmonary arterial hypertension (PAH) is a rare but devastating condition with highly heterogeneous patient groups and clinical responses. Molecular profiling of blood can be used to better understand the underlying pathology. Combining output from different analytical platforms has potential identify key signalling pathways. We combined transcriptomic, metabolomic genomic analyses investigate PAH in UK cohort. RNA sequencing was performed on whole samples patients recruited as part National...