A5065169223- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Antifungal resistance and susceptibility
- Thermal and Kinetic Analysis
- Research on Leishmaniasis Studies
- Fungal Infections and Studies
- Nanoplatforms for cancer theranostics
- Chemical Thermodynamics and Molecular Structure
- Metal complexes synthesis and properties
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antibiotic Resistance in Bacteria
- Click Chemistry and Applications
- Estrogen and related hormone effects
- Magnetism in coordination complexes
- Rural and Ethnic Education
- Multicomponent Synthesis of Heterocycles
- Fungal Plant Pathogen Control
- Nonlinear Optical Materials Research
- Tuberculosis Research and Epidemiology
- Organoselenium and organotellurium chemistry
- Chemistry and Chemical Engineering
- Energetic Materials and Combustion
- Insect and Pesticide Research
- Antimicrobial agents and applications
- Polyoxometalates: Synthesis and Applications
Universidade Federal da Paraíba
1999-2025
Rede de Química e Tecnologia
2018
Selene-ethylenelacticamide derivatives have been suggested as promising scaffolds with leishmanicidal activity. In this work, we demonstrated, for the first time, effectiveness of selene-ethylenelacticamide against mycobacteria. Firstly, selene-ethylenelacticamides inhibited growth laboratory strains Mycobacterium tuberculosis MIC values ranging from 10 to 20 µM. Importantly, three were active two multi-drug-resistant clinical isolates M. similar pan-sensitive strains. addition, NC31 and...
Aspergillus genus causes many diseases, and the species flavus is highly virulent. Treatment of aspergillosis involves azole derivatives such as voriconazole polyenes amphotericin B. Due to an increase in fungal resistance, treatments are now less effective; search for new compounds with promising antifungal activity has gained importance. The aims this study were evaluate effects synthetic amide 2-chloro-N-phenylacetamide (A1Cl) against strains elucidate its mechanism action. Thus, minimum...
In the current context of emerging drug-resistant fungal pathogens such as Candida albicans and parapsilosis, discovery new antifungal agents is an urgent matter. This research aimed to evaluate potential 2-chloro-N-phenylacetamide against fluconazole-resistant clinical strains C. parapsilosis. The activity was evaluated in vitro by determination minimum inhibitory concentration (MIC), fungicidal (MFC), inhibition biofilm formation its rupture, sorbitol ergosterol assays, association between...
The World Health Organization classifies Leishmania as one of the 17 “neglected diseases” that burden tropical and sub-tropical climate regions with over half a million diagnosed cases each year. Despite this, currently available anti-leishmania drugs have high toxicity potential to be made obsolete by parasite drug resistance. We chose analyze organoselenides for leishmanicidal given reduced inherent selenium displayed biological activity against Leishmania. Thus, activities 77 selenoesters...
Nine new compounds derived from selenoglycolic acid were synthesized, and their structures fully characterized by elemental analysis, infrared (IR), 1 H 13 C nuclear magnetic resonance (NMR).The evaluated in an silico study showed strong to moderate antibacterial activity against several strains of Staphylococcus aureus.In particular, three exhibited excellent activity, with minimum inhibitory concentrations (MICs) between 16 64 μg mL -1 .Furthermore, two the nine antifungal MIC 1024 512 .In...
The title compounds were synthesized from C-aryl-N-methylglycines by Naroylation followed a cyclodehydration to form the corresponding 1,3-oxazolium-5-olates. These not isolated but converted an in situ 1,3-dipolar cycloaddition/cycloreversion sequence using carbon disulphide. We have studied step acetic anhydride, trifluoroacetic anhydride and 1,3-dicyclohexylcarbodiimide (DCC) at temperatures exceding 60oC. Trifluroacetic proved be best reagent, giving better yield more easily purified...
The synthesis and complete 1 H 13 C NMR 19 F spectra of 2-(ptrifluoromethylphenyl)-3-methyl-4-(p-tolyl)-1,3-thiazolium-5-thiolate 2c 2-(p-chlorophenyl)-3-methyl-4-(p-isopropylphenyl)-1,3-thiazolium-5-thiolate 2d are described.Their structures consistent with spectral assignments obtained by 2D spectrometry.Structures were further confirmed elemental analysis, IR, UV mass spectrometry X-ray diffraction.
In this work, we report the synthesis of a new 1,3-thiazolium-5-thiolate derivative mesoionic compound (MIH 2.4Bl) and characterization its selective cytotoxicity on panel breast cancer cells lines. The cytotoxic effect MIH 2.4Bl cell lines was determined by XTT crystal violet assays, flow cytometry analysis, electron microscopy characterization, terminal deoxynucleotidyl transferase (TdT) deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) apoptosis assays. As using growth survival...
Objective: This study aimed to evaluate the antifungal and antibiofilm of 2-bromo-N-phenylacetamide (A1Br) against Cryptococcus neoformans in vitro.
 Methods: The compound was characterized by infrared 1H-nuclear magnetic resonance spectrometry data. Minimum inhibitory concentration (MIC) determined using plate dilution method biofilm formation inhibition crystal violet assay.
 Results: A1Br inhibited growth C. with MIC 0.25 0.5 μg/ml has good activity ×4, ≥80% growth.
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Abstract Pseudomonas aeruginosa is a non-lactose fermenting Gram-negative bacteria responsible for causing numerous nosocomial infections. The present research aimed to analyze the anti-Pseudomonas potential of 2-Chloro-N-(4-fluoro-3-nitrophenyl)acetamide (A8). antibacterial A8 was evaluated from Minimum Inhibitory Concentration (MIC), Bactericidal (MBC) and Association using checkerboard method. MIC MBC values were 512 µg/mL all P. strains evaluated, demonstrating predominantly bactericidal...
Article SYNTHESIS AND SPASMOLYTIC ACTIVITY OF MESOIONIC 1,4-DIPHENYL-5-(5- NITRO-2-FURANYL)-1,3,4-TRIAZOLIUM-2-THIOLATE HYDROCHLORIDE was published on December 1, 1996 in the journal Heterocyclic Communications (volume 2, issue 6).
This article has no abstract.
Introduction: invasive candidiasis is related to high rates of morbidity and mortality. There are few classes drugs available for the treatment this type infection index resistant strains increasing. Such circumstances highlight that search new pharmacotherapeutic alternatives increasingly necessary. This study investigated 2-Bromo-N-phenylacetamide, a substance whose antifungal activity has not yet been reported. Objective: evaluate its against isolates, by determining minimum inhibitory...
As imidas ciclicas constituem uma grande classe de substâncias obtidas por sintese orgânica, elas contem o grupo -CO-NR-CO-, onde R pode ser um hidrogenio, arila ou alquila, esses compostos se dividem em diversas sub-classes, dentre elas, as maleimidas, succinimidas, glutarimidas, ftalimidas e naftalimidas, bem como seus derivados1, 2, 3..
Klebsiella pneumoniae is a species of Gram-negative bacteria related to wide range infections and high rates drug resistance. The combined use antibacterial agents one the strategies that has been analyzed in recent years as part alternatives treatment drug-resistant infections. Recently, activity 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide demonstrated against K. pneumoniae, also indicating this acetamide did not show significant cytotoxic potential preliminary tests. Thus, it becomes an...
Purpose: Amides are proven to possess antimicrobial properties against both fungi and bacteria. The synthetic amide 2-bromo-N-phenylacetamide exhibits antifungal activity according scientific literature, however, data remains scarce. Given the clinical epidemiological importance as well increasing resistance in Candida spp., here we aimed better explore potential of fluconazole-resistant albicans, glabrata, parapsilosis for first time, tropicalis well. Methods: Minimum Inhibitory Fungicidal...
Para a CAPES o estágio de docência é parte integrante da formação do pós-graduando, objetivando preparação para docência, e qualificação ensino graduação. Nesse panorama objetiva-se com esse trabalho relatar as atividades desenvolvidas no decorrer Estágio Docência I curso Doutorado em Biotecnologia (RENORBIO) Centro Biotecnologia, realizado na disciplina Introdução à produção vegetal, âmbito Curso Bacharelado Agroecologia Universidade Federal Paraíba – UFPB. As ações foram estudantes...
Abstract Based on data from the World Health Organization, breast cancer is most common type of among women, accounting for about 15% all cancer-related deaths. Thus, new treatment options are urgently needed to decrease this mortality rate. In recent years, mesoionic compounds have shown promising potential as anti-cancer agents due their unique structure and reaction properties. We recently reported that a 1,3-thiazolium-5-thiolate compound (MIH 2.4Bl) inhibited oxidative phosphorylation...
Abstract Breast cancer is the most frequently diagnosed and leading cause of death in women worldwide, accounting for approximately 24% all new cases over 100 countries. Thus, breast one critical public health problems world facing women. There a growing interest studying biological activity mesoionic compounds, which possesses 5-membered heterocyclic aromatic ring associated with sextet electrons. Mesoionic compounds have shown promising potential as anti-cancer agents due to their unique...
This article has no abstract.